Influence of surface modifications to titanium on antibacterial activity in vitro

Yoshinari, Masao; Oda, Yutaka; Kato, Tsuyoshi; Okuda, K

doi:10.1016/s0142-9612(00)00392-6

Cited by 306 publications

(187 citation statements)

References 28 publications

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“…Finally, the selectively etched surface might reduce bacterial adhesion (Figure 7-c,d). This could be explained either by the nanoroughness (Figure 4) or the changes observed in the surface chemistry, in particular the increase in the fluorine content ( Figure 5, Table 4), or a combination of both [69,70].…”

Section: Discussionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

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Due to their outstanding mechanical properties and excellent biocompatibility, zirconiatoughened alumina (ZTA) ceramics have become the gold standard in orthopedics for the fabrication of ceramic bearing components over the last decade. However, ZTA is bioinert, which hampers its implantation in direct contact with bone. Furthermore, periprosthetic joint infections are now the leading cause of failure for joint arthroplasty prostheses. To address both issues, an improved surface design is required: a controlled micro-and nano-roughness can promote osseointegration and limit bacterial adhesion whereas surface porosity allows loading and delivery of antibacterial compounds. In this work, we developed an integrated strategy aiming to provide both osseointegrative and antibacterial properties to ZTA surfaces. The microtopography was controlled by injection molding. Meanwhile a novel process involving the selective dissolution of zirconia (selective etching) was used to produce nano-roughness and interconnected nanoporosity. Potential utilization of the porosity for loading and delivery of antibiotic molecules was demonstrated, and the impact of selective etching on mechanical properties and hydrothermal stability was shown to be limited. The combination of injection molding and selective etching thus appears promising for fabricating a new generation of ZTA components implantable in direct contact with bone.3

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Section: Discussionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

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“…Though the number of oral bacteria can be reduced by performing oral hygiene procedures using fluoride, mouthwash, and antibiotic administration (Choi et al, 2007), the most efficient way would be preventing the initial adherence and/or colonization by the bacterial population. There are some studies in the literature testing the antibacterial effect of TiO 2 against various microorganisms including Escherichia coli, S. mutans, Porphyromonas gingivalis, Lactobacillus acidophilus, Aggregatibacter actinomycetemcomitans, and C. albicans (Yoshinari et al, 2001). However, E. faecalis was brought under the spotlight in the literature for the first time in terms of antibacterial activity pertaining to photocatalysis in our study.…”

Section: Discussionmentioning

confidence: 99%

Photocatalytic antimicrobial effect of TiO2 anatase thin-film–coated orthodontic arch wires on 3 oral pathogens

Özyıldız¹,

Uzel²,

Hazar³

et al. 2014

Turk J Biol

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The aim of this study was to introduce antimicrobial activity to stainless steel orthodontic arch wires by coating them with TiO2 in anatase form. Stainless steel (0.016 × 0.022 inch), D-rect (0.016 × 0.022 inch), and multistranded hammered retainer wires (0.014 × 0.018 inch) were coated with TiO2 anatase by the sol-gel dip coating method. The wires were assessed for their photocatalytic antimicrobial activity against Streptococcus mutans, Candida albicans, and Enterococcus faecalis. After illumination under UVA (315– 400 nm) at 1.0 mW/cm2 for 1 h, the reduction efficiencies of the anatase-coated arch wires were calculated by using colony-forming unit counts. All anatase-coated arch wires showed remarkable inhibitor effects against the test microorganisms under UVA. The most efficient wire on S. mutans was the stainless steel wire, with a 99.99% reduction in growth, but multistranded hammered retainer wire was the most active against both C. albicans and E. faecalis, with 98.0% and 91.68% reduction rates, respectively. TiO2-coated arch wires exposed to UVA illumination showed significant antimicrobial activity when compared with uncoated samples and coated, but not UVA-exposed, samples. Our results suggest that the antimicrobial effect of TiO2-coated arch wires in long-lasting orthodontic treatments would be beneficial for the prophylaxis of caries

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“…Because systemic antibiotics often do not provide effective treatment for implant infections due to the phenomenon of drug resistance, it is important that the coating of the implant exhibit local antibacterial activity. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed [18][19][20][21][22][23][24][25][26][27][28][29][30]. In particular, silver has raised the interest of many investigators because of its good antimicrobial action and low toxicity [30,[40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

“…Several biomaterial surface treatments have been proposed as a means of reducing the incidence of implant-associated infections. There has been investigation into the covalent attachment of polycationic groups [18,19]; ion implantation, such as F+ [20]; impregnating or loading chitosan nanoparticles with antimicrobial agents [21,22]; coating implant surfaces with polymers drug-loaded [23,24]; and coating implant surfaces with either quaternary ammonium compounds, human serum albumin, or silver ions [25][26][27][28][29][30]. However, there are several shortcomings of these proposed techniques including limited chemical stability, local inflammatory reactions due to material composition, and a lack of controlled release kinetics from the coatings.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial iodine-supported titanium implants

et al. 2011

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Deep infection remains a serious complication in orthopedic implant surgery. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed. This study focused on evaluating the antibacterial activity of iodine-supported titanium (Ti-I 2 ) and impact on post-implant infection, as well as determining the potential suitability of Ti-I 2 as a biomaterial.External fixation pins were used in this experiment as trial implants because it was easy to make the septic models.The antibacterial activity of the metal was measured using a modification of the Japanese Industrial Standards method. Activity was evaluated by exposing the implants to Staphylococcus aureus or Escherichia coli and comparing reaction of pathogens to the Ti-I 2 versus the stainless steel and titanium controls. The Ti-I 2 clearly inhibited bacterial colonization more than the control metals. In addition, cytocompatibility was assessed by counting the number of colonies that formed on the metals. The three metals showed the same amount of fibroblast colony formation.Japanese white rabbits were used as an in vivo model. Three pins were inserted into both femora of six rabbits for histological analysis. Pin sites were inspected and graded for infection and inflammation. Fewer signs of infection and inflammatory changes were observed in conjunction with the Ti-I 2 pins. Furthermore, osteoconductivity of the implant was evaluated with osteoid formation surface of the pin. Consecutive bone formation was observed around the Ti-I 2 and titanium pins, while little osteoid formation was found around the stainless steel pins. These findings suggest that Ti-I 2 has antimicrobial activity and cytocompatibility.Therefore, Ti-I 2 substantially reduces the incidence of implant infection and shows particular promise as a biomaterial.

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Influence of surface modifications to titanium on antibacterial activity in vitro

Cited by 306 publications

References 28 publications

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Photocatalytic antimicrobial effect of TiO2 anatase thin-film–coated orthodontic arch wires on 3 oral pathogens

Antibacterial iodine-supported titanium implants

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