Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration

Strickstrock, Monika; Rothe, Holger; Grohmann, Steffi; Hildebrand, Gerhard; Zylla, Isabella M.; Liefeith, Klaus

doi:10.1515/bnm-2016-0013

Cited by 26 publications

(37 citation statements)

References 33 publications

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Section: Doi: 101515/bnm-2017-0007mentioning

confidence: 99%

“…A further modification possibility is the alteration of surface roughness of dental implant surfaces. Grohmann et al [8] report results on in vitro and in vivo experiments of rough yttria-stabilized tetragonal zirconia polycrystal materials revealing a cytocompatibility and a bone-implant contact that is very comparable to titanium as a reference material.The editors are aware that this issue can only highlight some of the multiple aspects in biofunctionalization. We hope that our selection of the articles included will stimulate your work towards innovative applications and you will enjoy this issue!…”

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Biofunctionalization

Petersen

2017

BioNanoMaterials

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Much effort is invested in the novel design and synthesis of biomaterials for the fabrication of biomedical applications as implants or nanoparticles with appropriate functionality, mechanical properties and durability. Depending on the application, requirements might differ considerably, ranging from high mechanical stress resistance to high transparency. These functions are generally governed by the bulk composition of the biomaterial. The biological response is in contrast largely controlled by the surface chemistry and structure. The rationale for surface modification of polymers is therefore straightforward: retaining the key physical properties of a biomaterial while modifying only the outermost surface to influence the biointeraction. Commonly observed interactions of any material with a biological system or system containing biomolecules cover adsorption or adhesion processes of proteins and bacteria or platelets as well as phagocytosis and fibrous encapsulation. Effective surface modification of biomaterials should mediate these interactions, for example, with the purpose of improved tissue-interface related-biocompatibility, that is especially important for modern implant design, which aim to improve implant integration while avoiding chronic inflammation and foreign body reactions, and thus loss of the intended implant function.Within the current issue, Hartmann and Krastev [1] outline specific strategies using polyelectrolyte multilayers to modulate these interactions between biomaterial surfaces and biological systems. Biofunctionalization is one particular form of surface modification involving the immobilization of biomolecules as proteins, peptides and polysaccharides or bioactive drugs with the same purpose. Various immobilization methods are available while the chosen strategy/design significantly defines the biological activity of the functionalized biomaterial. In this context, Spatz et al. [2] discuss the impact of spacer integration between biomaterial surface and the integrin-recognition motif cyclic RGD on the formation of integrin-based cellular adhesion. Furthermore, the immobilization strategy defines the short-term or long-term localization of the biomolecule on the biomaterials surface, which is explored using the example of the immobilization of the potent angiogenic vascular endothelial growth factor (VEGF) in order to improve the hemocompatibility and endothelialization of biodegradable polymer surfaces [3].One more important field is the biofunctionalization of nanostructured materials and nanoparticles with possible biomedical application for imaging and quantifying of target molecules such as proteins in assays, cells and tissues. In this context, Walter et al. [4] give general insights into the principles and factors controlling the binding affinity of aptamers, as promising alternative binders that can substitute antibodies in various applications immobilized to nanostructured materials. The short review by Salehi [5] additionally summarizes current designs of different biofu...

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Section: Doi: 101515/bnm-2017-0007mentioning

confidence: 99%

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confidence: 99%

Biofunctionalization

Petersen

2017

BioNanoMaterials

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“…These reports found improved bone bonding, achieved due to surface treatments when compared to untreated surfaces. [ 17 18 ]…”

Section: Introductionmentioning

confidence: 99%

“…Airborne particle abrasion with alumina particles lesser than 100 µm in size has been identified as a key factor in achieving an optimum surface roughness to enhance biological response of osteoblasts without causing structural damage to zirconia. [ 9 11 , 18 20 21 22 ]…”

Section: Introductionmentioning

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Surface characteristics and bioactivity of zirconia (Y-TZP) with different surface treatments

et al. 2020

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A BSTRACT Background: Zirconia being a bio-inert material needs to be surface treated to render it more bioactive and enhance its osseointegration potential. However, bioactivity studies focusing on the ability of sandblasting and ultraviolet photofunctionalization (UVP) surface treatments in inducing apatite precipitation using simulated body fluid (SBF) are lacking. Aim: The aim of the study was to comparatively evaluate the effect of two different surface treatments—sandblasting with 50 µm alumina and UVP with ultraviolet C (UVC) light on the bioactivity of zirconia. Materials and Methods: A total of 33 discs with dimensions 10 mm × 2 mm were obtained from zirconia blanks (Amann Girrbach, Koblach, Austria) and randomly divided into three groups ( n = 11), namely Group I (untreated), Group II (sandblasted), and Group III (UVP). Surface characteristics of representative test samples were analyzed using X-ray diffraction (XRD), atomic force microscopy (AFM), contact angle goniometry, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX), to assess type of crystal phase of zirconia, surface roughness, wettability, surface topography, and elemental composition, respectively. SBF was prepared and calcium content in SBF (Ca-SBF) was determined using inductively coupled plasma mass spectrometry (ICP-MS). Results: Data were analyzed by one-way analysis of variance (ANOVA), post hoc Tukey honestly significant difference (HSD), and Student’s t test for statistical significance ( P < 0.05, significant; P < 0.01, highly significant). Surface characteristics analyses revealed that XRD showed predominant tetragonal (t) zirconia crystal phase for all test groups. Mean surface roughness (Sa) of Group I was 41.83 nm, and it was significantly lesser than that of Group II (115.65 nm) and Group III (102.43 nm). Mean contact angles were 98.26°, 86.77°, and 68.03° for Groups I, II, and III, respectively, and these differences were highly significant. Mean pre-immersion Ca content in SBF was found to be 159 mg/L. Mean post-immersion Ca content was 70.10, 60.80, and 56.20 mg/L for Groups I, II, and III, respectively. Significant differences were found between Group I as compared to both Groups II and III. Bioactivity of Group III was marginally, but insignificantly higher with respect to Group II. Groups II and III were insignificant with respect to each other. Post-immersion XRD revealed predominant “t” phase, and SEM-EDX revealed well-formed, abundant calcium apatite layer on the treated samples as compared to that on untreated sample and an increasing Ca/P ratio from 1.15, 1.79 to 2.08, respectively from Group I to Group III. Conclusion: Within the limitations of this study, both sandblasting and UVP significantly a...

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Sliding behavior of zirconia porous implant surfaces against bone

et al. 2018

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Different zirconia porous layers were produced on zirconia dense zirconia substrates by slip casting using powder with different mean sizes: 40 μm (Z40), 70 μm (Z70), and 100 μm (Z100). The dynamic and static coefficients of friction against bovine femoral bone, mimicking the implantation process, were conducted using a ball-on-flat reciprocating sliding tribometer under 3 N of normal load. Additionally, the porous layers were assessed with regard to their low temperature degradation (aging). Results revealed that the porous layers were able to keep their integrity during the sliding testes against bone, with no zirconia particles being transferred to the bone. Results did not show significant differences (p > 0.05) in kinetic and static COF values for Z40, Z70, Z100, and GRAD specimens, ranging from 0.53 to 0.77 and 0.65 to 0.90, respectively. The aging tests revealed that all surfaces were prone to low temperature degradation (~49% of monoclinic content after 18 h). In conclusion, the cohesive integrity of the layers and relatively high COF observed reveled that zirconia porous layers may be considered for replacing the current implant surfaces, and are expected to improve their primary stability. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018.

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Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration

Cited by 26 publications

References 33 publications

Biofunctionalization

Biofunctionalization

Surface characteristics and bioactivity of zirconia (Y-TZP) with different surface treatments

Sliding behavior of zirconia porous implant surfaces against bone

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