Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration

Strickstrock, Monika; Rothe, Holger; Grohmann, Steffi; Hildebrand, Gerhard; Zylla, Isabella M.; Liefeith, Klaus

doi:10.1515/nano.0005.00024

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, in the present study, the medium roughness was below the reported values (123 nm). To contrast, the roughness corresponding to textured areas surpassed the reported level of microroughness (<1 µm) that was shown to favour the cell growth and attachment [ 63 ]. Here, for the anisotropic patterns, the medium value was maintained below 2 µm in contrast to the isotropic pillar arrays, where roughness in all cases was above 2 µm ( Table S1 ).…”

Section: Resultsmentioning

confidence: 99%

Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

Sima

Bonciu

Baciu³

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

Osseous implantology’s material requirements include a lack of potential for inducing allergic disorders and providing both functional and esthetic features for the patient’s benefit. Despite being bioinert, Zirconia ceramics have become a candidate of interest to be used as an alternative to titanium dental and cochlear bone-anchored hearing aid (BAHA) implants, implying the need for endowing the surface with biologically instructive properties by changing basic parameters such as surface texture. Within this context, we propose anisotropic and isotropic patterns (linear microgroove arrays, and superimposed crossline microgroove arrays, respectively) textured in zirconia substrates, as bioinstructive interfaces to guide the cytoskeletal organization of human mesenchymal stem cells (hMSCs). The designed textured micro-nano interfaces with either steep ridges and microgratings or curved edges, and nanoroughened walls obtained by direct femtosecond laser texturing are used to evaluate the hMSC response parameters and osteogenic differentiation to each topography. Our results show parallel micro line anisotropic surfaces are able to guide cell growth only for the steep surfaces, while the curved ones reduce the initial response and show the lowest osteogenic response. An improved osteogenic phenotype of hMSCs is obtained when grown onto isotropic grid/pillar-like patterns, showing an improved cell coverage and Ca/P ratio, with direct implications for BAHA prosthetic development, or other future applications in regenerating bone defects.

show abstract

Section: Resultsmentioning

confidence: 99%

Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

Sima

Bonciu

Baciu³

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Osteoblasts growing on the surface of alkali-sodium-modified specimens showed a significant degree of integration with the scaffold, which is of great importance for the development of implants. Considering that new implant surfaces are developed to improve biological cell responses, guiding the differentiation of mesenchymal stem cells toward osteoblasts and enhancing osseointegration, it is commonly reported in the most recent literature that cell growth is facilitated on rough substrates with diversified topography [ 3 , 91 , 92 , 93 , 94 ]. Additionally, effective osseointegration is significantly stimulated with increasing surface roughness of implants, inter alia titanium substrates (reviewed in [ 95 ]).…”

Section: Discussionmentioning

confidence: 99%

“…The limitations in preparing such surfaces include the possibility of reduced strength of the roughened material. Therefore, in the case of modifications used for long-term implants, it would be highly desirable to prepare surfaces with a roughness on the micrometer scale [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

et al. 2021

View full text Add to dashboard Cite

The surface modification of titanium substrates and its alloys in order to improve their osseointegration properties is one of widely studied issues related to the design and production of modern orthopedic and dental implants. In this paper, we discuss the results concerning Ti6Al4V substrate surface modification by (a) alkaline treatment with a 7 M NaOH solution, and (b) production of a porous coating (anodic oxidation with the use of potential U = 5 V) and then treating its surface in the abovementioned alkaline solution. We compared the apatite-forming ability of unmodified and surface-modified titanium alloy in simulated body fluid (SBF) for 1–4 weeks. Analysis of the X-ray diffraction patterns of synthesized coatings allowed their structure characterization before and after immersing in SBF. The obtained nanolayers were studied using Raman spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), and scanning electron microscopy (SEM) images. Elemental analysis was carried out using X-ray energy dispersion spectroscopy (SEM EDX). Wettability and biointegration activity (on the basis of the degree of integration of MG-63 osteoblast-like cells, L929 fibroblasts, and adipose-derived mesenchymal stem cells cultured in vitro on the sample surface) were also evaluated. The obtained results proved that the surfaces of Ti6Al4V and Ti6Al4V covered by TiO2 nanoporous coatings, which were modified by titanate layers, promote apatite formation in the environment of body fluids and possess optimal biointegration properties for fibroblasts and osteoblasts.

show abstract

“…Meanwhile, similar to titanium, zirconia is osteoconductive and biocompatible, while it causes less tissue reaction and toxic ion releasing to the surrounding tissues [ 38 , 119 , 213 ]. In particular, the alloy of zirconium with yttrium, which forms a stable structure of yttrium tetragonal zirconia polycrystal (Y-TZP) at room temperature, displayed advantageous biological and mechanical properties [ 119 , 213 ] to stimulate osteogenic cell proliferation during osseointegration as it has high fatigue resistance, elastic modulus, fracture toughness, bending strength, corrosion resistance, and low-temperature degradation [ 206 , 213 , 214 ]. Both animal and human studies demonstrate the deposition of newly formed mature bone in close proximity to zirconia implant surface with few marrow spaces, minimal inflammation, and numerous small actively secreting multinucleated osteoblasts [ 215 ].…”

Section: Materials Other Than Titaniummentioning

confidence: 99%

The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

Kligman

Ren

Chung

et al. 2021

JCM

187

View full text Add to dashboard Cite

Implant surface design has evolved to meet oral rehabilitation challenges in both healthy and compromised bone. For example, to conquer the most common dental implant-related complications, peri-implantitis, and subsequent implant loss, implant surfaces have been modified to introduce desired properties to a dental implant and thus increase the implant success rate and expand their indications. Until now, a diversity of implant surface modifications, including different physical, chemical, and biological techniques, have been applied to a broad range of materials, such as titanium, zirconia, and polyether ether ketone, to achieve these goals. Ideal modifications enhance the interaction between the implant’s surface and its surrounding bone which will facilitate osseointegration while minimizing the bacterial colonization to reduce the risk of biofilm formation. This review article aims to comprehensively discuss currently available implant surface modifications commonly used in implantology in terms of their impact on osseointegration and biofilm formation, which is critical for clinicians to choose the most suitable materials to improve the success and survival of implantation.

show abstract

Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration

Cited by 6 publications

References 0 publications

Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation

Contact Info

Product

Resources

About