Influence of surface tension-driven network parameters on backflow strength

Lee, Yonghun; Seder, Islam; Kim, Sung Jin

doi:10.1039/c8ra09756a

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…All of these problems are caused by the pressure difference at each inlet, which depends on the properties of liquids, including volume loaded, surface tension, viscosity, and density. 138,139 Based on the equations for surface tension and gravity, the built-in pressure P i of a liquid at a specific inlet can be written as 139…”

Section: A Backflow Prevention At Inletsmentioning

confidence: 99%

Passive micropumping in microfluidics for point-of-care testing

Wang

et al. 2020

Biomicrofluidics

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Suitable micropumping methods for flow control represent a major technical hurdle in the development of microfluidic systems for point-of-care testing (POCT). Passive micropumping for point-of-care microfluidic systems provides a promising solution to such challenges, in particular, passive micropumping based on capillary force and air transfer based on the air solubility and air permeability of specific materials. There have been numerous developments and applications of micropumping techniques that are relevant to the use in POCT. Compared with active pumping methods such as syringe pumps or pressure pumps, where the flow rate can be well-tuned independent of the design of the microfluidic devices or the property of the liquids, most passive micropumping methods still suffer flow-control problems. For example, the flow rate may be set once the device has been made, and the properties of liquids may affect the flow rate. However, the advantages of passive micropumping, which include simplicity, ease of use, and low cost, make it the best choice for POCT. Here, we present a systematic review of different types of passive micropumping that are suitable for POCT, alongside existing applications based on passive micropumping. Future trends in passive micropumping are also discussed.

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Section: A Backflow Prevention At Inletsmentioning

confidence: 99%

Passive micropumping in microfluidics for point-of-care testing

Wang

et al. 2020

Biomicrofluidics

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“…Capillary-driven flow has several limitations, including backflow, cross-contamination and asynchronous fluid movement inside microchannels. These problems are mainly caused by pressure differences at inlets and largely depend on the characteristics of the sample liquid [ 23 ]. Several strategies have been reported to overcome backflow problems, such as using a small flow bridge or vacuum storage [ 24 , 25 ].…”

Section: Principles Of Capillary-driven Flow Microfluidicsmentioning

confidence: 99%

Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics

et al. 2020

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Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community.

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“…Examples are capillary microfluidics [ 14 ], paper-based microfluidic [ 21 ], and vacuum-driven microfluidics [ 13 ]. However, achieving concentration gradients through passive pumping is challenging because of the difficulty in controlling the inherent pressure difference between liquid samples [ 22 , 23 ]. This pressure difference could arise from mismatches in material properties, liquid properties, inlet port size, and loaded sample volume.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution

et al. 2021

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We propose an integrated serial dilution generator utilizing centrifugal force with a degassed polydimethylsiloxane (PDMS) microfluidic device. Using gas-soluble PDMS as a centrifugal microfluidic device material, the sample can be dragged in any arbitrary direction using vacuum-driven force, as opposed to in a single direction, without adding further actuation components. The vacuum-driven force allows the device to avoid the formation of air bubbles and exhibit high tolerance in the surface condition. The device was then used for sample metering and sample transferring. In addition, centrifugal force was used for sample loading and sample mixing. In this study, a series of ten-fold serial dilutions ranging from 100 to 10−4 with about 8 μL in each chamber was achieved, while the serial dilution ratio and chamber volume could easily be altered by changing the geometrical designs of the device. As a proof of concept of our hybrid approach with the centrifugal and vacuum-driven forces, ten-fold serial dilutions of a cDNA (complementary DNA) sample were prepared using the device. Then, the diluted samples were collected by fine needles and subject to a quantitative polymerase chain reaction (qPCR), and the results were found to be in good agreement with those for samples prepared by manual pipetting.

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Influence of surface tension-driven network parameters on backflow strength

Abstract: This paper analyzes the effect of device elements on backflow of a surface tension-driven microfluidic device.

Cited by 5 publications

References 30 publications

Passive micropumping in microfluidics for point-of-care testing

Passive micropumping in microfluidics for point-of-care testing

Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics

An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution

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