Influence of surgical and postoperative treatment on survival in differentiated thyroid cancer

Lundgren, Catharina Ihre; Hall, Per; Dickman, Paul W.; Zedenius, Jan

doi:10.1002/bjs.5635

Cited by 55 publications

(35 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After excluding 1,405 patients (17.8%) with anaplastic and medullary thyroid cancers and 947 with follicular thyroid adenomas (12.0%), 5,554 individuals with DTC remained, of whom 5,123 had survived for at least 1 year after diagnosis. 4 Matching of these 5,123 patients with the Swedish Causes of Death Register for 1959 to 1999 identified 693 patients (potential cases) for whom thyroid cancer was reported as the cause of death.…”

Section: Study Target Populationsmentioning

confidence: 99%

“…A group of three specialists (a cardiologist, an oncologist, and an endocrine surgeon) independently evaluated the medical records to confirm DTC as the cause of death. Ninety-eight patients had to be excluded for various reasons, 4 and 595 sets of patients and controls were generated by randomly sampling one control for each patient, matched for age at diagnosis (5-year age groups), sex, and 10-year calendar periods of diagnosis via incidence density sampling.…”

Section: Data Collectionmentioning

confidence: 99%

See 1 more Smart Citation

Simplifying the TNM System for Clinical Use in Differentiated Thyroid Cancer

Onitilo

Engel

Lundgren

et al. 2009

JCO

View full text Add to dashboard Cite

A B S T R A C T PurposeThe TNM stratification has been found useful at stratifying patients with differentiated thyroid carcinoma (DTC) into prognostic risk groups. However, it is cumbersome to implement clinically given the large number of bins within this system and the complicated system of arriving at stage information. Patients and MethodsWe decided to quantify each variable in this system to arrive at a simplified quantitative alternative to the TNM system (QTNM) and compare this with the conventional system. We used our electronic record system to identify 614 cases of DTC managed at our institution from 1987 to 2006. Cancer-specific survival (CSS) and disease-free survival (DFS) were calculated by the Kaplan-Meier method, and a simplified QTNM score was devised using a Cox proportional hazards model. ResultsWe were able to quantify the TNM system as follows: 4 points each for age older than 45 years and presence of neck nodal metastases while 6 points for tumor size larger than 4 cm or extrathyroidal extension and 1 point for nonpapillary DTC. A sum of 0 to 5 points was low risk, 6 to 10 points intermediate, and 11 to 15 points high risk. Comparison with the conventional TNM system and two other systems revealed similar or better discrimination with the QTNM and this discrimination was maintained when this risk stratification was applied to a unique validation set. ConclusionThe QTNM system as opposed to the conventional TNM system seems to be a simple and effective method for risk stratification for both recurrence and cancer-specific mortality.

show abstract

Section: Study Target Populationsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Simplifying the TNM System for Clinical Use in Differentiated Thyroid Cancer

Onitilo

Engel

Lundgren

et al. 2009

JCO

View full text Add to dashboard Cite

show abstract

“…Several studies from Western countries have demonstrated that total thyroidectomy offers a better prognosis than hemithyroidectomy [9][10][11][12][13][14][15][16][17]. These results might be low grade evidence, because there were not including randomized studies in almost of these reports.…”

Section: Surgical Treatment (Thyroidectomy)mentioning

confidence: 99%

Therapeutic strategy for low-risk thyroid cancer in Kanaji Thyroid Hospital [Review]

et al. 2014

View full text Add to dashboard Cite

Abstract. It is well-known that differentiated thyroid carcinoma (DTC) has a generally indolent character and shows a favorable prognosis in comparison with many other carcinomas. The therapeutic strategy for patients with DTC in Japan has differed from that in Western countries. Total thyroidectomy followed by radioactive iodine (RAI) ablation has been standard in Western countries, whereas limited hemi-thyroidectomy and subtotal thyroidectomy has been extensively accepted in Japan. Papillary thyroid carcinoma (PTC) accounts for over 90% of all thyroid cancers in Japan. The majority of patients with PTC are categorized into a low-risk group on the basis of the recent risk-group classification schemes, and they show excellent outcomes. Several management guidelines for thyroid cancers have been published in Western countries. However, the optimal therapeutic options for PTC remain controversial, and high-level clinical evidence aimed at resolving these issues is lacking. Moreover, as socioeconomic differences in medical care exist, conventional policies for the treatment of PTC have differed between Japan and other countries. This review focuses on the special features of treatment in Japan for patients with low-risk DTC involving subtotal thyroidectomy without adjuvant therapies, rather than total thyroidectomy with RAI, with the aim of preserving quality of life. At our institution in Japan, we have had extensive experience with RAI treatment for high-risk DTC patients, and this represents a very rare situation. Here we introduce the therapeutic strategy for low-risk thyroid cancer in Japan, including the measures adopted at our institution.

show abstract

“…Thyroid cancers have an indolent course and a favorable prognosis, and with long-term survival rates of more than 90%, 5 benefit of early diagnosis of this disease is uncertain, 6 but many researchers believe treatment at an early stage reduces recurrence and mortality. 7,8 Numerous risk factors for thyroid cancer, such as radiation exposure, age, and sex, have been welldocumented.…”

Section: Introductionmentioning

confidence: 99%

Clinical, Surgical and Histopathologic Outcomes of Filipino Patients with Micropapillary Thyroid Carcinoma in a Tertiary University Hospital in the Philippines

Guerrero

Malong

Caringal

et al. 2014

JAFES

View full text Add to dashboard Cite

Objective. Micropapillary thyroid carcinoma (micro-PTC) has a good prognosis but a number of cases will present with aggressive behavior. This study aims to determine the clinical outcomes with surgical management and histopathologic characteristics of Filipino patients with micro-PTC at University of Santo Tomas Hospital.Methodology. 139 patients were diagnosed with micro-PTC from the year 2004-2011. Seventy five patients had complete data and were included in this retrospective study. Chi square test with Yates correction, T-test for tumor diameter, statistical means and percentages were used in data analysis.Results. A total of 1,689 thyroid surgeries were done between 2004 and 2011. There were 1,054 patients (62.4%) diagnosed with benign thyroid tumor(s) and 635 patients (37.6%) with well-differentiated thyroid carcinoma. Of these, 139 (22%) patients have micro-PTC. The prevalence rate of micro-PTC was 22%, with a female predominance (86.6%). The patients' ages ranged from 24-80 years old with a mean age of 47 years. Comparison of groups showed that having either incidental or non-incidental micro-PTC is independent of the clinical variables of the patient. Two (2.6%) patients initially presented with cranial and supraclavicular metastasis. This study had a low recurrence rate (5.3%) and a mortality rate of 1.3%.Conclusion. Male gender is the only significant variable for lymph node and distant metastasis. The patient's age, family history of cancer, number of foci, size and histological type of tumor have no prognostic value.

show abstract

Influence of surgical and postoperative treatment on survival in differentiated thyroid cancer

Abstract: In operated patients, the most important prognostic factor was complete removal of the tumour. The extent of removal of remaining thyroid tissue was of prognostic importance in stage III disease only. Adjuvant postoperative treatment did not influence the prognosis favourably.

Cited by 55 publications

References 18 publications

Simplifying the TNM System for Clinical Use in Differentiated Thyroid Cancer

Simplifying the TNM System for Clinical Use in Differentiated Thyroid Cancer

Therapeutic strategy for low-risk thyroid cancer in Kanaji Thyroid Hospital [Review]

Clinical, Surgical and Histopathologic Outcomes of Filipino Patients with Micropapillary Thyroid Carcinoma in a Tertiary University Hospital in the Philippines

Contact Info

Product

Resources

About