Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats

Кастыро, И. В.; Reshetov, Igor V.; Khamidulin, G. V.; Shilin, S. S.; Торшин, В. И.; Kostyaeva, M. G.; Popadyuk, V. I.; Yunusov, T. Yu.; Shmaevsky, P. E.; Shalamov, K. P.; Kupryakova, A. D.; Doroginskaya, E. S.; Sedelnikova, A. D.

doi:10.1134/s160767292102006x

Cited by 14 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various stressors lead to changes in the functional state of neurons with the development of subsequent morpho-physiological abnormalities 2 . The hippocampus receives special attention in stress because it is very sensitive to various damaging factors 3,4 . In neuronal damage, as in damage to other cells, p53…”

Section: Introductionmentioning

confidence: 99%

“…The transcriptional control of p53 of these synaptic genes is conserved in mouse neurons and the human brain 6 . Morphologically altered neurons after exposure to stressors can have basophilia in their staining 3,7 . Such neurons are usually referred to as dark neurons.…”

Section: Introductionmentioning

confidence: 99%

“…Such neurons are usually referred to as dark neurons. They have speci c morphological features: shrunken cytoplasm, karyopiknosis, corkscrew axon 3,7 . Apoptosis is believed to occur in these neurons 8 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of septoplasty as a stressor in p53 and dark neurons formation when septoplasty simulation in rats.

Khamidulin

Dyachenko

Kostyaeva

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

The aim of this study was to determine the role of surgical stress on the formation of p53-positive and dark neurons (DN) in the hippocampus, and to examine the parallelism of their formation in the pyramidal layer of the hippocampus.Simulated septoplasty was performed on 20 Wistar rats. The hippocampus and dentate gyrus (DG) were examined, in which the number of DN and p53-positive neurons was determined at 2, 4 and 6 days after surgery.Compared with the control group (n = 5), the number of DN and p53-positive neurons increased in experimental animals at all periods. A direct relationship was obtained between the increase in the number of DN and p53-positive neurons in the hippocampal formation.Septoplasty simulation in rats results in the pathogenetic cascades onset, which, in its turn, changes the morpho-functional properties of neurons of the pyramidal layer of the hippocampus and contributes to their neuroplasticity. Activation of NMDS receptors of neurons during stress apparently, initiates two ways of neuron life – the beginning of p53 protein expression and the DN formation. Both ways can finally lead to apoptosis. The formation of dark neurons and the expression of the p53 protein in them are most likely to be interconnected and can probably provide neuroprotective mechanisms.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of septoplasty as a stressor in p53 and dark neurons formation when septoplasty simulation in rats.

Khamidulin

Dyachenko

Kostyaeva

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various stressors lead to changes in the functional state of neurons with the development of subsequent morpho-physiological abnormalities [2]. The hippocampus receives special attention in stress because it is very sensitive to various damaging factors [3,4]. In neuronal damage, as in damage to other cells, p53 protein is an activator of transcription of a specific set of target genes, a cell cycle inhibitory regulatory factor and an effector of cellular responses to damage, which include cell cycle arrest and apoptosis [5].…”

Section: Introductionmentioning

confidence: 99%

“…The transcriptional control of p53 of these synaptic genes is conserved in mouse neurons and the human brain [6]. Morphologically altered neurons after exposure to stressors can have basophilia in their staining [3,7]. Such neurons are usually referred to as dark neurons.…”

Section: Introductionmentioning

confidence: 99%

Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Кастыро¹,

Mikhalskaia²,

Khamidulin³

et al. 2022

ArveMED

View full text Add to dashboard Cite

The aim of this study was to determine the role of surgical stress on the formation of p53-positive and dark neurons (DN) in the hippocampus, and to examine the parallelism of their formation in the pyramidal layer of the hippocampus. Simulated septoplasty was performed on 20 Wistar rats. The hippocampus and dentate gyrus (DG) were examined, in which the number of DN and p53-positive neurons was determined at 2, 4 and 6 days after surgery. Compared with the control group (n = 5), the number of DN and p53-positive neurons increased in experimental animals at all periods. A direct relationship was obtained between the increase in the number of DN and p53-positive neurons in the hippocampal formation. Septoplasty simulation in rats results in the pathogenetic cascades onset, which, in its turn, changes the morpho-functional properties of neurons of the pyramidal layer of the hippocampus and contributes to their neuroplasticity. Activation of NMDS receptors of neurons during stress, apparently, initiates two ways of neuron life – the beginning of p53 protein expression and the DN formation. Both ways can finally lead to apoptosis. The formation of dark neurons and the expression of the p53 protein in them are most likely to be interconnected and can probably provide neuroprotective mechanisms.

show abstract

Changes in the Time-Domain of Heart Rate Variability and Corticosterone after Surgical Trauma to the Nasal Septum in Rats

Кастыро

Popadyuk

Reshetov

et al. 2021

Dokl Biochem Biophys

View full text Add to dashboard Cite

Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats

Cited by 14 publications

References 14 publications

Role of septoplasty as a stressor in p53 and dark neurons formation when septoplasty simulation in rats.

Role of septoplasty as a stressor in p53 and dark neurons formation when septoplasty simulation in rats.

Role of Septoplasty as a Stressor in P53 and Dark Neurons Formation During Septoplasty Simulation in Rats

Changes in the Time-Domain of Heart Rate Variability and Corticosterone after Surgical Trauma to the Nasal Septum in Rats

Contact Info

Product

Resources

About