Influence of temperature, water content and type of organic acid on the formation, stability and properties of functional natural deep eutectic solvents

Savi, Lizandra Kamradt; Carpiné, Danielle; Waszczynskyj, Nina; Ribani, Rosemary Hoffmann; Haminiuk, Charles Windson Isidoro

doi:10.1016/j.fluid.2019.01.025

Cited by 70 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…liquid state within wide temperature range, insignificant volatility, chemical and thermal stability, nonflammability, nontoxicity of constituting ingredients), but also due to their sustainable 'green' properties. Components of NADES are abundantly present in nature, readily available, and biorenewable (Dai et al 2013c;Pena-Pereira, Kloskowski, and Namie snik 2015), and since the NADES are generally composed of nontoxic substances occurring naturally in foods, they may be directly incorporated in food formulations without additional purification steps, being a major advantage over conventional solvents (Savi et al 2019). Majority of NADES combinations are regarded as highly biodegradable and of low toxicity (Paiva et al 2014;Rado sevi c et al 2016b;Wen et al 2015).…”

Section: Natural Deep Eutectic Solvents (Nades)mentioning

confidence: 99%

The perspectives of natural deep eutectic solvents in agri-food sector

Mišan

Nađpal

Stupar

et al. 2019

Critical Reviews in Food Science and Nutrition

198

View full text Add to dashboard Cite

The principles of 'green chemistry' are gaining importance in agri-food sector due to the need to reduce pollution from toxic chemicals, make industrial processes safer and more sustainable, and to offer 'clean-labeled products' required by the consumers. The application of natural deep eutectic solvents (NADES)natural product-based green liquids is considered the promising alternative to conventional organic solvents. This review is intended to summarize and discuss recent advances related to physicochemical properties of NADES, their applications, compatibility with analytic techniques and toxicological profile, pointing out the challenges and necessary improvements for their wider utilization in agri-food sector. NADES allow extraction of wide range of food compounds and they are proven to be convenient for food-related applications. However, their potential for industrial scale-up utilization is not completely investigated. Examined NADES are readily biodegradable, but only preliminary studies on NADES toxicity which include limited number of NADES molecules are available. Apart from fundamental research dealing with NADES formation and the nature of the interactions and structure underpinning the liquid phase formation, the question of purity of NADES obtained by different synthetic methodologies need to be addressed in the future. Data on physicochemical properties of synthetized NADES are still needed as they are relevant for industrial applications.

show abstract

Section: Natural Deep Eutectic Solvents (Nades)mentioning

confidence: 99%

The perspectives of natural deep eutectic solvents in agri-food sector

Mišan

Nađpal

Stupar

et al. 2019

Critical Reviews in Food Science and Nutrition

198

View full text Add to dashboard Cite

show abstract

“…Once identified the characteristic alkaloids in Boldo leaves, their extraction with seven selected NADES was evaluated (Table 3) [25][26][27][28][37][38][39][40][41][42][43]. The efficiency of these NADES was compared with methanol and water.…”

Section: Extractability Of Boldine From Peumus Boldus Leaves With DIVmentioning

confidence: 99%

“…Since high viscosity of NADES is one of the main drawbacks for its use, it is worth mentioning that in all the extractions performed in the present study the viscosity was reduced by adding a maximum of 20% of water (Table 3). It has been reported that this strategy does not alter the supramolecular NADES network; on the contrary, it has a dramatic effect by increasing the mass transfer and mobility of the molecules [41,42]. Therefore, the addition of water combined with temperature help to reduce the strong intermolecular interactions ruled by the H bond network in eutectic solvents [43,50].…”

Section: Extraction Yields Of Total Polyphenols From Peumus Boldus Lementioning

confidence: 99%

Green Extraction of Alkaloids and Polyphenols from Peumus boldus Leaves with Natural Deep Eutectic Solvents and Profiling by HPLC-PDA-IT-MS/MS and HPLC-QTOF-MS/MS

Torres-Vega

Gómez‐Alonso

Pérez‐Navarro

et al. 2020

Plants

View full text Add to dashboard Cite

Peumus boldus Mol., is a Chilean medicinal tree used for gastrointestinal and liver diseases. Such medicinal properties are associated with the presence of bioactive flavonoids and aporphine alkaloids. In this study, a new green and efficient extraction method used seven natural deep eutectic solvents (NADES) as extraction media. The extraction efficiency of these NADES was assessed, determining the contents of boldine and total phenolic compounds (TPC). Chemical profiling of P. boldus was done by high-performance liquid chromatography coupled to photo diode array detector and electrospray ion-trap mass spectrometry (HPLC-PDA-ESI-IT/MS) and electrospray ionization quadrupole time-of-flight high-resolution mass spectrometry (HPLC-ESI-QTOF-MS). Among the NADES tested, NADES4 (choline chloride-lactic acid) and NADES6 (proline-oxalic acid) enable better extraction of boldine with 0.427 ± 0.018 and 2.362 ± 0.055 mg of boldine g−1 of plant, respectively. Extraction of boldine with NADES4 and NADES6 was more efficient than extractions performed with methanol and water. On the other hand, the highest TPC were obtained using NADES6, 179.442 ± 3.79 mg of gallic acid equivalents (GAE g−1). Moreover, TPC in extracts obtained with methanol does not show significant differences with NADES6. The HPLC-PAD-MS/MS analysis enable the tentative identification of 9 alkaloids and 22 phenolic compounds. The results of this study demonstrate that NADES are a promising green extraction media to extract P. boldus bioactive compounds and could be a valuable alternative to classic organic solvents.

show abstract

“…Also, they have the potential to be employed as an extraction media for bioactive combinations [60,61]. The HBDs and HBAs are chosen for constructing the NADESs via the following categories: organic acids, alcohols, sugars, ChCl, and amino acids [62]. The diversity of raw constitutes makes it possible to form a broad array for different blends so that more than a hundred NADESs have been reported to date [56].…”

Section: Preparation Of Desmentioning

confidence: 99%

Deep eutectic solvents (DESs): A short overview of the thermophysical properties and current use as base fluid for heat transfer nanofluids

Jafari

Fatemi

Estellé

2021

Journal of Molecular Liquids

View full text Add to dashboard Cite

Nowadays, different types of strategies are proposed and tested to find the best scenario for upgrading the productivity of heat transfer fluids, especially nanofluids. Some optimum empirical conditions demonstrated that the best size, shape, and nature of nanoparticles and their appropriate dispersion have positive influences on nanofluid thermal conductivity improvements. Therefore, the specific physicochemical properties of the base fluid can be taken into account as one of the decisive factors in heat transfer operations. Deep eutectic solvents (DESs) are nominated as valuable materials to meet the demands for sustainable ecological processes and open opportunities for overcoming the limitations of conventional fluids.The purpose of this study is to briefly introduce the DESs for evaluating their thermal potential applicability and their use to produce nanofluids. DES-based nanofluids represent a new and creative type of heat transfer fluids that possess high potential in different target applications and are not harmful to the environment. This type of nanofluid has higher thermal properties than the base DESs. Increasing the temperature and the volume fraction of nanoparticles lead to further increment in their thermal properties. In this study, the chemical structure and preparation method have been addressed for the DES and DES-based nanofluids. Also, the theoretical approaches have been considered for modeling and predicting their behavior. A discussion was extended to investigate the usage of DES as host fluid for producing nanofluids, and its advantages and drawbacks are also presented. It is deduced that the DES-based nanofluids are one of the smart choices for the progression of nanofluids and give the most promising results for application in heat transport fluids. The contents may shed light on a detailed awareness of the heat transfer potential of the DESs.

show abstract

Influence of temperature, water content and type of organic acid on the formation, stability and properties of functional natural deep eutectic solvents

Cited by 70 publications

References 25 publications

The perspectives of natural deep eutectic solvents in agri-food sector

The perspectives of natural deep eutectic solvents in agri-food sector

Green Extraction of Alkaloids and Polyphenols from Peumus boldus Leaves with Natural Deep Eutectic Solvents and Profiling by HPLC-PDA-IT-MS/MS and HPLC-QTOF-MS/MS

Deep eutectic solvents (DESs): A short overview of the thermophysical properties and current use as base fluid for heat transfer nanofluids

Contact Info

Product

Resources

About