Influence of Terbium Ions and Their Concentration on the Photoluminescence Properties of Hydroxyapatite for Biomedical Applications

Abstract

A new generation of biomaterials with terbium-doped hydroxyapatite was obtained using a coprecipitation method. The synthesis of new materials with luminescent properties represents a challenging but important contribution due to their potential applications in biomedical science. The main objective of this study was to revel the influence of terbium ions on the design and structure of hydroxyapatite. Different concentrations of terbium, described by the chemical formula Ca10−xTbx(PO4)6(OH)2, where x is in the range of 0 to 1, were considered. The consequence of ion concentration on hydroxyapatite morphology was also investigated. The morphology and structure, as well as the optical properties, of the obtained nanomaterials were characterized using X-ray powder diffraction analysis (XRD), Fourier Transform Infrared spectrometry (FTIR), SEM and TEM microscopy, UV-Vis and photoluminescence spectroscopies. The measurements revealed that terbium ions were integrated into the structure of hydroxyapatite within certain compositional limits. The biocompatibility and cytotoxicity of the obtained powders evaluated using MTT assay, oxidative stress assessment and fluorescent microscopy revealed the ability of the synthesized nanomaterials to be used for biological system imaging.

Electrodeposition of Calcium Phosphate Coatings on Metallic Substrates for Bone Implant Applications: A Review

“…Bismuth (Bi 3+ ), gallium (Ga 3+ ), and selenium (SeO 2− 3 ) show simultaneous positive impacts against bacteria and tumor cells [210][211][212][213][214][215][216]. Erbium (Er 3+ ), europium (Eu 3+ ), or terbium (Tb 3+ ) are added for their photoluminescence properties used in biological imaging systems [217][218][219][220][221][222]. The variety of all these ions and their biological impacts on calcium phosphate coatings used for bone implant applications will be part of the upcoming developments of the electrodeposition process.…”

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

“…In the past 20 years, electrospinning has grown significantly as a micro- and nanofiber processing method. It continues to represent the most effective method to produce them in a variety of designs for tissue engineering and regenerative medicine, providing modern and efficient solutions for current day-to-day challenges [ 75 , 76 , 77 , 78 ].…”

Synthesis and Investigation of Physicochemical Properties and Biocompatibility of Phosphate–Vanadate Hydroxyapatite Co-Doped with Tb3+ and Sr2+ Ions

“…In the case of the obtained materials, isomorphic substitution takes place in both the cationic and anionic subnetwork. In the cationic subnetwork, Ca 2+ ions, the ionic radius of which equals 0.99 Å, are partially replaced by Sr 2+ ions (1.13 Å) and Tb 3+ ions (0.923 Å) [ 44 , 45 ]. These Ca 2+ ions represent two crystallographically independent calcium atoms: Ca(I) and Ca(II).…”