Influence of the ABO blood groups and secretor status on bleeding and on perforation of duodenal ulcer.

Abstract

ABO BLOOD GROUPS IN RELATION TO DUODENAL ULCERSince Aird, Bentall, Mehigan, and Roberts (1954) convincingly demonstrated a high incidence of blood group 0 in duodenal ulcer subjects there have been a number of confirmatory studies carried out in different ethnic groups and populations (McConnell, 1966). Studies have also been undertaken to see if there is an especially strong association between blood group 0 and some particular category of duodenal ulcer patient. Brown, Melrose, and Wallace (1956) found that there was a marked association between blood group 0 and duodenal ulcer subjects requiring surgery, and also an association which fell short of statistical significance in subjects who had suffered perforation or bleeding compared with those in whom duodenal ulcer had been diagnosed by radiology alone. However, Langman and Doll (1965) did not find a high incidence of blood group O in subjects who came to operation in their series of 479 duodenal ulcers but found that the association of blood group 0 with bleeding was very significant. Horwich, Evans, McConnell, and Donohoe (1966) confirmed the association between blood group 0 and bleeding in duodenal ulcer subjects and demonstrated a high incidence of blood group 0 also in subjects who had sustained a serious gastro-duodenal bleed but did not have any radiologically demonstrable gastro-duodenal lesion.In the study of Horwich et al. (1966) 125 subjects with perforated duodenal ulcer were blood grouped and 72 (58-1 %) were found to be of blood group 0 compared with 50-6 % in 549 subjects with duodenal ulcer which had not perforated or bled. Langman, Doll, and Saracci (1967) Wort, and Green (1964)and Fodor and Urcan (1966). Studies designed to discover a relationshipbetween ABH secretion and clinical categories of duodenal ulcer have shown a tendency for non-secretors to come to operation more frequently than secretors (Langman and Doll, 1965) but this was not confirmed by Horwich et al. (1966). Bleeding duodenal ulcer subjects have a similar incidence of ABH secretors as uncomplicated duodenal ulcer subjects (Langman and Doll, 1965;Horwich et al., 1966). A small series of 125 perforated duodenal ulcers has been investigated for ABH secretion by Horwich et al. (1966) and 38 (304 %) were non-secretors. This is a rather lower frequency than that found in bleeding ulcers or those which had caused only pain or obstruction. THE PRESENT STUDYThe aims of the present communication are (1) to see if there is an association between blood group 0 and bleeding outside the gastrointestinal tract, viz., menorrhagia; (2) to expand our series of blood grouped and secretor-typed perforated duodenal ulcer subjects to see if this clinical category is associated with either blood group 0 ornon-secretion. METHODSMENORRHAGIA CASES These cases were ascertained by examining case records of women diagnosed as 319 on 10 May 2018 by guest. Protected by copyright.

Influence of ABO blood groups on primary hemostasis

“…Little is known about the consequences of these differences. However, a higher risk of gastrointestinal bleeding complications is described for patients with group O blood, 6–9 whereas a higher incidence of ischemic heart disease and thromboses is reported in persons with the other ABO blood groups 10–15 …”

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 ( Secretor ) genotype

“…A large body of evidence suggests that this maintenance may be because of numerous tradeoffs surrounding host-microbe interactions. For example, nonsecretors are resistant to infection with the Norwalk (Noro) (17) and respiratory viruses (18) but are more susceptible to duodenal ulcers (19), rheumatic fever (20), and cholera (21). Furthermore, the breast milk of secreting mothers provides protection against Campylobacter jejuni to their offspring by exploiting the binding affinity of the bacterium to fucosyloligosaccharides (22).…”

Long-Term Survival of Patients with Gastrointestinal Haemorrhage with Special Reference to the ABO Blood Groups

“…A lower plasma concentration of coagulation factor VIII is found in patients with group 0 compared to group A (43), but the clinical significance of this is uncertain. Apparently the bleeding tendency of patients with group 0 is only found in the gastric and duodenal mucosa, not in the uterine muscosa as demonstrated in metrorrhagia (19). Horwich et al found, in a group of patients with gastrointestinal haemorrhage and no demonstrable ulcer during X-ray examination, a significant excess of group 0, and considered diagnostic error a possible explanation of this (26).…”