Influence of the Adsorption of Phenobarbital to Dietary Fibers and Semi-solid Agents Used for the Manufacturing of Enteral Nutrients

Myotoku, Michiaki; Akiyama, Sanae; Matsuura, Arisa; Omotani, Sachiko; Nagai, Katsutoshi; Hatsuda, Yasutoshi; Mukai, Junji; Hirotani, Yoshihiko

doi:10.5649/jjphcs.43.438

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Alternatively, the xanthan gum-based thickener may act as a diffusion barrier limiting AMP dissolution into the medium. It has been reported that xanthan gum adsorbs various drugs [21] [22]. It is postulated that the reason for this is the excellent acid resistance, heat resistance and drought resistance of the gum [23] [24], and the intermolecular associations of xanthan gum wrapping around the drug and preventing it from getting wet, even though xanthan gum-based thickeners are said safety and their effect in modifying bolus rheology in the therapeutic medical for dysphagia [25].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia

Odanaga¹,

Kojima²,

Kabeya³

et al. 2022

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Purpose: The present research was performed to evaluate the effect of food thickeners on the bitterness and dissolution of bitter drugs when co-administered to patients with dysphagia. Methods: Amlodipine besilate (AMPB) powder was used as a model drug. Starch-and xanthan gum-based food thickeners were examined, with swallowing-aid jelly as a reference. The line-spread test (LST), texture prolife analysis (TPA) were done firstly. In related to AMPB powder mixed with food thickeners solution, a conventional dissolution test simulating the oral cavity was performed, the amlodipine (AMP) concentration and taste sensor output for dissolved medium versus time profiles were developed. The dissolution test at pH 1.2 and 4.5, representing typical gastric conditions for younger or elderly people, was performed in two kinds of thickener solution and swallowing-aid jelly those were mixed with AMPB powder. Results: LST demonstrated that xanthan gum-based food thickeners fulfilled the requirements for patients with dysphagia but that starch-based food thickeners did not. In TPA, hardness and adhesiveness decreased proportionally as the concentration increased for both kinds of food thickener. Conventional dissolution test simulating oral cavity demonstrated the following bitterness ranking: xanthan gum-based food thickener < starch-based food thickener < swallowing-aid jelly. In dissolution test at pH 1.2 and 4.5, starch-based thickener and swallowing-aid jelly mixed with AMPB powder showed complete AMP dissolution. However, xanthan gum-based food thickeners mixed with AMPB powder showed about only 60% AMP dissolution after 120 minutes. Conclusion: Although xanthan gum-based food thickeners were successful in masking the bitterness of AMP, they may reduce its

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Section: Discussionmentioning

confidence: 99%

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia

Odanaga¹,

Kojima²,

Kabeya³

et al. 2022

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“…However, xanthan gum-based thickening agents are difficult to digest owing to their characteristics 9) . It has also been reported that the addition of xanthan gumbased thickening agents delays the disintegration and elution of oral medicines 10) and results in the adsorption of medicines to xanthan gum, the main ingredient of these foods 8,[11][12][13][14] ． Using a thickening agent, VCM powder may be administered to patients with dysphagia in the treatment of CDI. However, mixing VCM powder with thickening agents after dissolving it in water may cause changes in the properties of the powder, such as clumping, instead of the desired thickening.…”

Section: Yakugaku Zasshi Advance Publicationmentioning

confidence: 99%

“…Previous studies have reported that the addition of xanthan gum-based thickening agents decreases the efficacy of drugs such as phenobarbital and carbamazepine 13) . Therefore, it is possible that the decrease in VCM concentration at 0 min after the addition of 3% Tsururinko Quickly in the present study was caused by the adsorption of VCM to xanthan gum.…”

Section: [Insert Figures 8-11 Near Here]mentioning

confidence: 99%

Effect of Thickening Agents on the <i>In Vitro</i> Antibacterial Activity of Vancomycin Hydrochloride Powder

et al. 2023

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When vancomycin hydrochloride powder (VCM powder) mixes with xanthan gumbased thickening agents in food, lumps or other property-related changes may occur.Previous studies have reported delayed disintegration and elution of the drug and its adsorption on to xanthan gum, which is the main ingredient of thickened food products. If the addition of thickening agents can affect the antimicrobial activity of VCM powder as previously reported, it might interfere with the treatment of Clostridioides difficile infection (CDI). In this study, we investigated the effect of the addition of xanthan gum-based thickening agents on the antibacterial activity of YAKUGAKU ZASSHI Advance PublicationVCM against Clostridioides difficile in vitro. The VCM concentration at 0 min after adding 3% Tsururinko Quickly to VCM powders (Shionogi and Meiji) was lower than that of the control (Shionogi: 65.15% ± 35.57%, Meiji: 77.00% ±15.81% (mean ± standard deviation), **P < 0.01, Dunnet 's test). However, the VCM concentration at 30 min after the addition recovered to the control level. The drug susceptibility tests for C. difficile and Staphylococcus aureus using the disk diffusion method showed no effect of addition of 3% Tsururinko Quickly. Our in vitro evaluations showed that the addition of xanthan gum-based thickeners to VCM powders had a negligible effect on the treatment of CDI.

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“…To prevent the risk of aspiration or choking in dysphasia patients, thickened fluids and texture-modified foods that are designed to slow down the flow of liquids and foods have been used [3]. Various types of thickeners have been developed and evaluated [4] [5] [6] [7] including modified starch thickeners and gum thickeners, both with and without flavoring [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Loaded Oral Disintegration Tablets: Assessment of Potential Suitability for Patients with Dysphagia

Odanaga¹,

Kojima²,

Uno³

et al. 2022

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The purpose of this research was to evaluate the effect of starch-and xanthan gum-based food thickeners on the bitterness and dissolution of amlodipine besilate (AMPB) loaded orally disintegrating tablets (ODT) for potential use with patients with dysphagia. A conventional dissolution test simulating the oral cavity was performed and the taste sensor output of the dissolved sample was evaluated over a 60-seconds period. When four types of AMPB loaded ODTs were tested alone, at 60 seconds, branded product (A) was the least bitter, followed by generic product (B)/generic product (C) which were equal, and finally generic product (D) which was the most bitter. Inhibition of bitterness of AMPB loaded ODTs mixed thickeners, 1.0 (w/v) % xanthan gum-based food thickener solution was significantly strong. The 7.1 (w/v) % and 4.7 (w/v) % starch-based food thickeners solution also effective in bitterness inhibition compared to the 2.4 (w/v) % starch-based food thickener solution. The dissolution test under pH 1.2 in related to 7.1 (w/v) % and 4.7 (w/v) % starch-based thickener contained each of AMPB loaded ODTs were associated with an almost complete amlodipine (AMP) dissolution (almost 90% at 10 minutes), whereas the 1.0, 2.0, 3.0 (w/v) % xanthan gum-based food thickener solution containing AMPB loaded ODTs did not show complete AMP dissolution and there were large variations in the initial dissolution stage. This suggests that a mixture of xanthan gum-based thickener and AMPB loaded ODT poses a risk of reduction of bioavailability. In conclusion, a mixture of 4.7 (w/v) % or 7.1 (w/v) % starch-based thickener with ODTs provides complete release of AMP and superior bitterness inhibition, so is the best choice for administration to patients with dysphagia.

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Influence of the Adsorption of Phenobarbital to Dietary Fibers and Semi-solid Agents Used for the Manufacturing of Enteral Nutrients

Cited by 3 publications

References 5 publications

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Powder When Co-Administered with Thickeners to Patients with Dysphagia

Effect of Thickening Agents on the <i>In Vitro</i> Antibacterial Activity of Vancomycin Hydrochloride Powder

The Effect of Food Thickeners on the Bitterness and Dissolution of Amlodipine Besilate Loaded Oral Disintegration Tablets: Assessment of Potential Suitability for Patients with Dysphagia

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