The article presents the results of studying the influence of the genealogical affiliation of animals and the origin of bulls, as well as the age of dairy cattle, on the quantitative and qualitative indicators of lactation performance. It is given the physiological justification for obtaining high productivity of dairy cattle. The results have shown that the use of bulls of different genotypes for insemination results in different productivity. So, according to the 305-day first and third lactation yields inseminated by the evaluated bulls, the bull-producer Baron 87485 of the Reflection Sovering line stands out. In terms of 305-day second lactation yield, the bull Adam 167 has the highest productivity. Analysis of the hematological picture makes it possible to establish that the blood parameters of the experimental animals, although they are within the physiologically acceptable norms, but the influence of bulls is noticeable on the content of erythrocytes, hemoglobin and total protein. This indicates and justifies more intensive processes with an increase in the lactation performance of dairy cattle.