Influence of the anti-allergic drug oxatomide on the signal transduction mechanism in a mast cell model

Mechanism of action of the nonlipophilic antiallergic drug eclazolast (REV 2871) in the inhibition of mediator release in a mast cell model

“…In previous studies with the lipophilic drugs astemizole and oxatomide an effect on tyrosine phosphorylation was observed even in resting cells [12,27], however, for eclazolast no detectable stimulating or suppressing effect on the level of tyrosine phosphorylation has been found in resting Vol. 48, 1999 Mechanism of action of the nonlipophilic antiallergic drug eclazolast (REV 2871) in the inhibition of mediator release 573 nor has it been found in activated cells (data not shown).…”

“…Effect of the drugs on the level of IP 3 was measured as presented previously [12], and was based on the method of Bominaar and Van Haastert [13].…”

“…It was demonstrated that lipophilic antiallergic drugs inhibited Ca 2+ influx [6,12,[14][15]. Therefore, it was investigated whether eclazolast affects Ca 2+ fluxes.…”