Despite the vast literature on heavy‐precipitation events in South Asia, synoptic conditions and moisture sources related to extreme precipitation in Nepal have not been addressed systematically. We investigate two types of synoptic conditions—low‐pressure systems and midlevel troughs—and moisture sources related to extreme precipitation events. To account for the high spatial variability in rainfall, we cluster station‐based daily precipitation measurements resulting in three well‐separated geographic regions: west, central, and east Nepal. For each region, composite analysis of extreme events shows that atmospheric circulation is directed against the Himalayas during an extreme event. The direction of the flow is regulated by midtropospheric troughs and low‐pressure systems traveling toward the respective region. Extreme precipitation events feature anomalous high abundance of total column moisture. Quantitative Lagrangian moisture source diagnostic reveals that the largest direct contribution stems from land (approximately 75%), where, in particular, over the Indo‐Gangetic Plain moisture uptake was increased. Precipitation events occurring in this region before the extreme event likely provided additional moisture.