Influence of the aryl substituent identity in 4-arylamino-3-nitrocoumarins on their antimicrobial activity

Deki, Vidoslav; Radulovi, Niko; Vukievi, Rastko; Deki, Biljana; Stojanovi-Radi, Zorica; Pali, Radosav

doi:10.5897/ajpp10.408

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…Tetracycline and Nystatine were used as the reference drugs. 53 A series of new coumarin derived carboxylate ligands and their silver(I) complexes (20) were synthesized, characterized and screened by Creaven et al for their in-vitro antibacterial activity against a range of Gram positive stains and Gram negative as well as for their antifungal activity. While none of the ligands showed any antimicrobial activity, a number of the Ag(I) complexes exhibited potent activity.…”

Section: Antimicrobal Activitymentioning

confidence: 99%

Coumarins: The Antimicrobial agents

Al-Majedy

Kadhum²,

Al-Amiery

et al. 2017

SRP

125

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Emergence of resistance by bacterial and fungal stains towards existing antimicrobial agents is one of the major problem as well as motivation to synthesize a new class of antimicrobial agents possessing potent activity compared to commonly used therapy. Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen and its derivatives are of wide awareness because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favourable selectivity ratio. Coumarins are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, anti-oxidant, anti-parasitic, anti-helmintic, anti-proliferative, anti-convulsant, anti-inflammatory and anti-hypertensive activities etc. The information given in this manuscript may be helpful in the further research of better antimicrobial agents having lesser microbial resistance and improved antimicrobial profile.

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Section: Antimicrobal Activitymentioning

confidence: 99%

Coumarins: The Antimicrobial agents

Al-Majedy

Kadhum²,

Al-Amiery

et al. 2017

SRP

125

View full text Add to dashboard Cite

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“…The 4-arylamino-3-nitrocoumarins were evaluated for their antibacterial and antifungal activities against pathogenic strains S. aureus, B. cereus, B. subtilis, E. coli, Klebsiella pneumoniae, Salmonella enterica and yeast C. albicans and A. niger. Compound (11) was found greatest anticandidal as compared to other compounds and Tetracycline and Nystatine were used as the reference drugs (Dekic et al, 2011). A series of 3-cynnamoyl-4hydroxycoumarins (12) were tested on bacteria P. aeruginosa, E. coli, Salmonella typhimurium, Bordatella bronchiseptica, B. subtilis and S. aureus.…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Pharmacologically potentials of different substituted coumarin derivatives

Int¹

2019

Preprint

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Coumarin and its derivatives are widely spread in nature. Coumarin goes to a group as benzopyrones, which consists of a benzene ring connected to a pyrone moiety. Coumarins displayed a broad range of pharmacologically useful profile. Coumarins are considered as a promising group of bioactive compounds that exhibited a wide range of biological activities like anti-microbial, anti-viral, antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer, anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensive activities etc. The coumarin compounds have immense interest due to their diverse pharmacological properties. In particular, these biological activities make coumarin compounds more attractive and testing as novel therapeutic compounds.Capsule Summary: Coumarin derivatives are considered as promising bioactive compounds that exhibited a wide range of biological activities.Cite This Article As: M. Asif. Pharmacologically potentials of different substituted coumarin derivatives. Chemistry

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“…Varying the types of substitution and substituent identity led to different conformations of the molecules that had a profound impact on their biological activity [10]. We have previously synthesized a number of coumarin derivatives with significant antimicrobial and/or antioxidant activities [5,[11][12][13].…”

Section: Commentmentioning

confidence: 99%