Influence of the c.1517G&gt;C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population

Zhao, Zhiming; Li, C G; Hu, Min; Gao, Yu‐Hong; Liu, R

doi:10.4238/2014.june.16.5

Cited by 4 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously c.1517G>C genetic variant of the XRCC1 gene also was reported to be significantly associated with pancreatic cancer in a study conducted by Zhao et al, (2014) They noted that The CC genotype was significantly associated with an increased risk of pancreatic cancer. They reported that C allele may contribute to development of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Our study aimed to investigate the association between XRCC1 (c.1517G>C) polymorphism and the risk of HCC in Egyptian patients who are chronically infected with HCV. This genetic variant represents a non-synonymous G to C mutation in exon 14 of the XRCC1 gene, resulting in glycine (Gly) to alanine (Ala) amino acid replace-ment (p.Gly506Ala) (Zhao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Naguib

Helwa

Soliman

et al. 2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Naguib

Helwa

Soliman

et al. 2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…Two case-control studies on the relationship between c.1517G > C polymorphism and susceptibility to pancreatic cancer were included in our systematic review. Zhao et al [21] and Hou et al [22] reported that the XRCC1 c.1517G > C variant is significantly associated with pancreatic cancer susceptibility in the Chinese population. According to the current evidence-based literature, we thought that there was significant association between XRCC1 gene c.1517G > C polymorphism and pancreatic cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association between Polymorphisms of X-Ray Repair Cross Complementing Group 1 Gene and Pancreatic Cancer Risk: a Systematic Review with Meta-Analysis

Chen

Wang

2017

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Emerging evidences have shown that common genetic polymorphisms in X-ray repair cross complementing group 1 (XRCC1) gene may be associated with the development of pancreatic cancer, but individually published studies and previous meta-analyses revealed inconclusive results. The aim of our study was to investigate the association between polymorphisms in XRCC1 gene and pancreatic cancer risk. We conducted a search of PubMed, Embase, the Cochrane Library and Web of Science databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined as measures of the strength of association between polymorphisms of XRCC1 and pancreatic cancer risk. Sensitivity analysis and publication bias were evaluated. All analyses were undertaken using the STATA 13.0. A total of 10 studies were included in this systematic review. Five common functional singlenucleotide polymorphisms (SNPs) in XRCC1 gene were found, including Arg399Gln G > A (rs25487), Arg194Trp C > T (rs1799782), Arg280His G > A (rs25489), c.1517G > C, c.1471G > A. Results from our stratified analysis based on Hardy-Weinberg equilibrium (HWE) showed that there was a robust significant association between Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.743, 95% CI 0.576-0.958, P = 0.022; heterozygous model, OR 0.701, 95% CI 0.525-0.936, P = 0.016; dominant model, OR 0.710, 95% CI 0.537-0.939, P = 0.016). We also found a statistically significant association between c.1517G > C polymorphism and pancreatic cancer risk (Allelic model, OR 1.252, 95% CI 1.064-1.473, P = 0.007). No significant results were obtained for Arg399Gln, Arg194Trp and c.1471G > A polymorphisms. The present meta-analysis suggested that Arg280His and c.1517G > C polymorphisms in XRCC1 gene were associated with pancreatic cancer risk.

show abstract

“…[1][2][3][4][5] Molecular epidemiological studies have shown that XRCC genes are significantly associated with lung cancer, [6][7][8][9] oral cancer, 10 bladder cancer, [11][12][13] ovarian cancer, 14,15 esophageal cancer, 16 and gastric cancer. [17][18][19][20][21][22][23] Moreover, studies have revealed that XRCC gene polymorphism is highly variable in different ethnic populations. [24][25][26][27][28] Studies have shown that defect in DNA repair mechanism is significantly associated with the increased risk of breast cancer (BC) in females.…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Devi

Ahmed

Narain

et al. 2017

Technol Cancer Res Treat

View full text Add to dashboard Cite

X-ray repair cross complementary group gene is one of the most studied candidate gene involved in different types of cancers. Studies have shown that X-ray repair cross complementary genes are significantly associated with increased risk of breast cancer in females. Moreover, studies have revealed that X-ray repair cross complementary gene polymorphism significantly varies between and within different ethnic groups globally. The present case–control study was aimed to investigate the association of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer in females from northeastern region of India. The present case–control study includes histopathologically confirmed and newly diagnosed 464 cases with breast cancer and 534 apparently healthy neighborhood community controls. Information on sociodemographic factors and putative risk factors were collected from each study participant by conducting face-to-face interviews. Genotyping of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) was carried out by polymerase chain reaction-restriction fragment length polymorphism. For statistical analysis, both univariate and multivariate logistic regression analyses were performed. We also performed stratified analysis to find out the association of X-ray repair cross complementary genes with the risk of breast cancer stratified based on menstrual status. This study revealed that tryptophan allele (R/W-W/W genotype) in X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer (adjusted odds ratio = 1.44, 95% confidence interval = 1.06-1.97, P < .05 for R/W-W/W genotype). Moreover, it was found that tryptophan allele (W/W genotype) at codon 194 of X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer in premenopausal females (crude odds ratio = 1.66, 95% confidence interval = 1.11-2.46, P < .05 for R/W-W/W genotype). The present study did not reveal any significant association of X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer. The present study has explored that X-ray repair cross complementary 1A (Arg194Trp) gene polymorphism is significantly associated with the increased risk of breast cancer in premenopausal females from northeastern region of India which may be beneficial for prognostic purposes.

show abstract

Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population

Cited by 4 publications

References 21 publications

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Association between Polymorphisms of X-Ray Repair Cross Complementing Group 1 Gene and Pancreatic Cancer Risk: a Systematic Review with Meta-Analysis

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Contact Info

Product

Resources

About