Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use

Ribeiro, Daniela de Oliveira; Lobo, Bianca Waruar; Volpato, Nádia Maria; Veiga, Venício Féo da; Cabral, Lúcio Mendes; Sousa, Valéria Pereira de

doi:10.1186/1475-2891-8-51

Cited by 32 publications

(34 citation statements)

References 53 publications

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“…This formulation was chosen due its similarity to in uterus conditions, which favours greater bone mineralization [35], but with potential risk due to the low final volume and possible interactions leading to loss of vitamins, that, in this formulation was overestimated [4,36-38]. Some works have suggested a possible chemical instability due interaction between vitamins and oligoelements mixed in the same bag.…”

Section: Resultsmentioning

confidence: 99%

Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use

Ribeiro

Pinto

Lima

et al. 2011

Nutr J

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BackgroundThe objective of this work was to study the vitamins B1, B2, B6 and C stability in a pediatric formulation containing high amounts of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulfate, pediatric vitamins and trace elements under different conditions using developed and validated analytical methods.MethodsThe study was carried out during 72 h with formulations packaged in recommended storage temperature (4°C) and 25°C, with and without photoprotection.ResultsThe results showed that the methodologies used for assessing the chemical stability of vitamins B1, B2, B6 and C in the formulation were selective, linear, precise and accurate. The vitamins could be considered stable in the formulation during the three days of study if stored at 4°C. When stored at 25°C vitamin C presented instability after 48 h.ConclusionThe pediatric formulation containing high amount of calcium in the presence of organic phosphate, amino acids, glucose, sodium chloride, magnesium sulphate, pediatric vitamins and trace elements packaged in bag-type trilaminate presented a shelf life of the 72 h, when maintained under refrigeration, between 2°C and 8°C. This shelf life was measured considering the vitamins studied. Further studies are needed including all the vitamins present in this formulation.

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Section: Resultsmentioning

confidence: 99%

Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use

Ribeiro

Pinto

Lima

et al. 2011

Nutr J

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“…With the introduction of organic phosphates it may be possible to include high calcium and lipid in neonatal AIO [17]. Recently, Ribeiro Dde et al [18 ] have documented physiochemical compatibility and stability of AIO for neonatal use. In this study, three parenteral nutrition mixtures with increasing calcium content (0, 46.5 mg/100 ml and 93 mg/ml) and fixed organic phosphate concentrations including 20% LCT/MCT lipid emulsions (dose: 1-3 g/kg/day) met recommended standards (no precipitated particles and lipid globule size >5 mm).…”

Section: Lipid Administration In Neonatesmentioning

confidence: 99%

Lipids for parenteral nutrition in neonates

Deshpande

Simmer

2011

Current Opinion in Clinical Nutrition and Metabolic Care

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Since the first soybean oil-based lipid emulsions were introduced 50 years ago, progress has been made in understanding the composition, dose and clinical effects of parenteral lipids in neonatal patients. However there is a paucity of data in terms of definitive head-to-head trials of different novel lipid emulsions evaluating short-term as well as long-term clinically important outcomes including neurodevelopment. Future research is required to determine long-term benefits of novel lipid emulsions for neurological outcome and effects on the immune system.

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“…Some authors have also described optical microscopy as an alternative method for characterizing or evaluating physical stability of the PN. These methods use direct observation to determine the size distribution of the internal phase – lipid globules [3,19]. Peroxide levels, zeta potential and visual aspects are additional parameters that can be evaluated when characterizing the physicochemical properties of TPN [16,20].…”

Section: Introductionmentioning

confidence: 99%

Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

Lobo

Veiga

Cabral

et al. 2012

Nutr J

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ObjectiveThe present study aimed to evaluate the influence of the relative composition of trace elements and vitamins in physicochemical stability of neonatal parenteral nutrition.Material and methodsThree formulations for neonatal administration were selected; the main variable was the presence of trace elements and vitamins. The analyses where carried out immediately after preparation and at 24 h, 48 h, 72 h and 7 days after preparation. Three methods were selected to determine globule size: light obscuration, dynamic light scattering and optical microscopy. Complementary evaluation including visual inspection, determination of pH and osmolarity, peroxide levels and measurements of zeta potential were also performed.ResultsThere was an observable alteration in color and phase separation in the PN stored at 25°C and 40°C. Neither globule size pattern, nor any other physicochemical characteristic evaluated appeared to be considerably altered in any of the analyzed formulations even after 7 days of storage at 5°C. Globule size in all the PN studied was consistent with the established limit, below 500 nm by DLS measurement, and PFAT5 was below 0.05% under all storage temperatures.ConclusionConcomitant presence of trace elements and vitamins in the same neonatal formulation did not alter the evaluated aspects of stability.

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Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use

Cited by 32 publications

References 53 publications

Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use

Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use

Lipids for parenteral nutrition in neonates

Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

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