Influence of the chain length of chitosan on complement activation

Suzuki, Y.; Miyatake, K; Okamoto, Yoshiharu; Muraki, Einosuke; Minami, Saburo

doi:10.1016/j.carbpol.2003.07.002

Cited by 29 publications

(17 citation statements)

References 14 publications

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“…Chitosan was described as a complement activator. The complement activation was shown to increase with the number of NH 2 groups included along the chitosan chain (37,38). Other studies reported that chitosan-bearing surfaces exhibited an adsorption of proteins but no complement activation (39).…”

Section: Influence Of Type Of Polysaccharidesmentioning

confidence: 94%

“…The higher protection against complement activation observed with chitosan could be due either to an improved steric repulsion or to an inhibition of complement activation by chitosan. Some polyanions and polycations were described as inhibitors of complement (44,45), but this was not the case for chitosan, which was described to be an activator of the alternative pathway of complement (37,39,40). Thus, it appears that an improved steric repulsion, rather than an inhibition of complement, is more likely to explain the increased capacity to reduce complement activation by the chitosan brush at the nanoparticle surface.…”

Section: Influence Of Type Of Polysaccharidesmentioning

confidence: 99%

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Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

2006

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Section: Influence Of Type Of Polysaccharidesmentioning

confidence: 94%

Section: Influence Of Type Of Polysaccharidesmentioning

confidence: 99%

Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

2006

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“…73, 82–84 When chitosans with different chain lengths (8.8 to 80 kDa) were compared, complement activation increased with chain length and number of NH 2 groups. 85 Difference in the conformation of polymer chains on the NP surface can dramatically influence the ability to bind to plasma proteins and activate the complement system. For example, polyalkylcyanoacrylate (PACA) NPs with dextran coating prepared in two different methods had two types of dextran conformation and density, which had opposite complement activation effects.…”

Section: In Vitro Characterization Of Npsmentioning

confidence: 99%

Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies

et al. 2013

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Nanoparticles have received enormous attention as a promising tool to enhance target-specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to characterize a new system and predict its clinical efficacy. These techniques enable efficient comparison across nanoparticles and facilitate a product optimization process. On the other hand, we recognize their limitations as a prediction tool, which owe to inadequate applications and overly simplified test conditions. This article provides a critical review of in vitro and in vivo techniques currently used for evaluation of nanoparticles and introduces emerging techniques and models that may be used complementarily.

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“…29,30 In the present study, we attempted to determine how PNS translocated into mast cells and led to degranulation and histamine release.…”

Section: Mechanism Of Pns-triggered Mast Cell Degranulationmentioning

confidence: 99%

Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery

Sun

et al. 2014

IJN

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In order to limit the adverse reactions caused by polysorbate 80 in Taxotere ® , a widely used formulation of docetaxel, a safe and effective nanocarrier for this drug has been developed based on micelles formed by a new class of well-defined polyoxyethylene sorbitol oleate (PSO) with sorbitol as the matrix in aqueous solution. The physicochemical properties of the amphiphilic surfactant and the resulting micelles can be easily fine-tuned by the homogeneous sorbitol matrix and pure oleic acid. Composition, critical micelle concentration, and entrapment efficiency were investigated by ultraviolet visible spectroscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, fluorospectrophotometry, and high-performance liquid chromatography. In vitro and in vivo evaluation revealed that PSO had exceptionally low hemolysis and histamine release rates compared with commercial polysorbate 80. Moreover, the tumor targeting delivery of PSO was investigated by in vivo imaging in S180 tumor-bearing mice. The results suggest that this novel delivery system, PSO, provides an acceptable alternative to polysorbate 80 for delivery of docetaxel. Further, due to the hypoallergenic nature of PSO, the mechanism of pseudoallergy caused by the polyoxyethylene nonionic surfactant was investigated. Based on in vitro cell analysis, it was assumed that the initial contact of polyoxyethylene nonionic surfactant with mast cells provoked pseudoallergy via polyamine receptor-mediated endocytosis.

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Influence of the chain length of chitosan on complement activation

Cited by 29 publications

References 14 publications

Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies

Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery

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