Influence of the chirality of carbon nanodots on their interaction with proteins and cells

Yan, Huijie; Cacioppo, Michele; Megahed, Saad; Arcudi, Francesca; Đorđević, Luka; Zhu, Dingcheng; Schulz, Florian; Prato, Maurizio; Parak, Wolfgang J.; Feliu, Neus

doi:10.1038/s41467-021-27406-1

Cited by 36 publications

(28 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in vitro study by Duan et al showed that BSA adsorbed on GO weakened the interaction between the phospholipid membrane of A549 cells and the surface of GO, which subsequently reduced its uptake [ 96 ]. These results are also in union with the findings of higher uptake of CDs by THP-1 macrophages in serum-free conditions [ 97 ]. In another study, the authors confirmed a significant decrease of cytotoxic effects of blood protein loaded GO [ 98 ].…”

Section: Recognition and Uptakesupporting

confidence: 90%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

View full text Add to dashboard Cite

In the field of science, technology and medicine, carbon-based nanomaterials and nanoparticles (CNMs) are becoming attractive nanomaterials that are increasingly used. However, it is important to acknowledge the risk of nanotoxicity that comes with the widespread use of CNMs. CNMs can enter the body via inhalation, ingestion, intravenously or by any other route, spread through the bloodstream and penetrate tissues where (in both compartments) they interact with components of the immune system. Like invading pathogens, CNMs can be recognized by large numbers of receptors that are present on the surface of innate immune cells, notably monocytes and macrophages. Depending on the physicochemical properties of CNMs, i.e., shape, size, or adsorbed contamination, phagocytes try to engulf and process CNMs, which might induce pro/anti-inflammatory response or lead to modulation and disruption of basic immune activity. This review focuses on existing data on the immunotoxic potential of CNMs, particularly in professional phagocytes, as they play a central role in processing and eliminating foreign particles. The results of immunotoxic studies are also described in the context of the entry routes, impacts of contamination and means of possible elimination. Mechanisms of proinflammatory effect depending on endocytosis and intracellular distribution of CNMs are highlighted as well.

show abstract

Section: Recognition and Uptakesupporting

confidence: 90%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…[19,20] These are, in fact, key properties to push forward the applications of CNDs in many fields, ranging from sensing to catalysis. [21][22][23][24][25][26][27] Strikingly, a simple, fast and straightforward NMR analysis may often reveal that the properties of interest arise from molecular species present as impurities rather than from CNDs.…”

mentioning

confidence: 99%

Nuclear Magnetic Resonance Reveals Molecular Species in Carbon Nanodot Samples Disclosing Flaws

et al. 2022

Self Cite

View full text Add to dashboard Cite

Carbon nanodots are currently one of the hot topics in the nanomaterials world, due to their accessible synthesis and promising features. However, the purification of these materials is still a critical aspect, especially for syntheses involving molecular precursors. Indeed, the presence of unreacted species or small organic molecules formed during solvothermal treatments can affect the properties of the synthesized nanomaterials. To illustrate the extreme importance of this issue, we present two case studies in which insufficient purification results in misleading conclusions regarding the chiral and fluorescent properties of the investigated materials. Key to identify molecular species is the use of nuclear magnetic resonance, which proves to be an effective tool. Our work highlights the need to include nuclear magnetic resonance as a standard characterization technique for carbon‐based nanomaterials, to minimize the risk of observing properties that arise from molecular species, rather than the target carbon nanodots.

show abstract

“…The approach has been applied for the detection of various cations, anions and small molecules. [163][164][165] For instance, due to the binding of metal ions by CDs, electrons are transferred from CDs to the empty d orbitals of metal ions, leading to fluorescence quenching. Several studies have identified specific surface functional groups of CDs that can coordinate metal ions (such as Cu 2þ and Fe 3þ ) in biological systems.…”

Section: On-off Mechanismmentioning

confidence: 99%