Influence of the Circadian System on Disease Severity

Litinski, Mikhail; Scheer, Frank A.J.L.; Shea, Steven A.

doi:10.1016/j.jsmc.2009.02.005

Cited by 81 publications

(57 citation statements)

References 209 publications

(188 reference statements)

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“…Epidemiological evidence of day/night patterns in disease severity suggests interacting roles of behavioural triggers and endogenous circadian systems [1]. Circadian misalignment has been implicated in the development of obesity, insulin resistance, diabetes mellitus, and cardiovascular disease [1].…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

Matteucci

Giampietro²

2012

CDR

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Circadian misalignment has been implicated in the development of diabetes mellitus and cardiovascular disease. Circadian rhythms of blood pressure (BP) and heart rate (HR) have long been known and the mechanisms controlling them have been actively investigated in physiology and disease. In this respect, the introduction of 24-hour ambulatory blood pressure monitoring (ABPM) has enabled a more accurate assessment of circadian BP patterns in order to solve diagnostic uncertainty or to establish dipper status. However, attention has been mainly focused on measures of extent (midline estimating statistic of rhythm, MESOR, and amplitude) rather than timing (acrophase) of changes within a cycle. The review summarises 1) evidence for altered characteristics of BP rhythm (in particular, phase shifts along the time axis) in animal and human diabetes mellitus, 2) the mechanisms that have been supposed to underlie the observed changes in cardiovascular function before diabetes onset and during progression of the disease, and 3) the adverse consequences that may result from an altered circadian BP rhythm.

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Section: Introductionmentioning

confidence: 99%

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

Matteucci

Giampietro²

2012

CDR

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“…Asthma shares a lot of characteristics with allergic diseases, including genetic risk factors (Bousquet et al 2000). Asthma episodes, as well as asthma exacerbations, are more prone to happen during the night and early morning compared to other times of the day both in adults and in children (Smolensky et al 2007;Reinberg et al 1988;Turner-Warwick 1988;Smolensky and D'Alonzo 1997;Hoskyns et al 1995;Jarjour 1999;Bohadana et al 2002;Litinski et al 2009). One of the first studies involving 3000 asthma patients found that asthma episodes during washout from regular maintenance asthma treatment occurred 70-fold more frequently between 4 am and 5 am compared to 2 pm-3 pm (Dethlefsen and Repges 1985).…”

Section: Asthmamentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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“…It has been recognized that circadian rhythms performs an important role in certain disease states as these disease states have chronological aspects related to them (108). One such example is asthma which has shown to become formidable in the early hours of morning (2-8 am) when most patients are asleep (108).…”

Section: Chronotherapeutism From Polymer Refabricationmentioning

confidence: 99%

A Review of Polymeric Refabrication Techniques to Modify Polymer Properties for Biomedical and Drug Delivery Applications

et al. 2013

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Abstract. Polymers are extensively used in the pharmaceutical and medical field because of their unique and phenomenal properties that they display. They are capable of demonstrating drug delivery properties that are smart and novel, such properties that are not achievable by employing the conventional excipients. Appropriately, polymeric refabrication remains at the forefront of process technology development in an endeavor to produce more useful pharmaceutical and medical products because of the multitudes of smart properties that can be attained through the alteration of polymers. Small alterations to a polymer by either addition, subtraction, self-reaction, or cross reaction with other entities have the capability of generating polymers with properties that are at the level to enable the creation of novel pharmaceutical and medical products. Properties such as stimuli-responsiveness, site targeting, and chronotherapeutics are no longer figures of imaginations but have become a reality through utilizing processes of polymer refabrication. This article has sought to review the different techniques that have been employed in polymeric refabrication to produce superior products in the pharmaceutical and medical disciplines. Techniques such as grafting, blending, interpenetrating polymers networks, and synthesis of polymer complexes will be viewed from a pharmaceutical and medical perspective along with their synthetic process required to attain these products. In addition to this, each process will be evaluated according to its salient features, impeding features, and the role they play in improving current medical devices and procedures.

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Influence of the Circadian System on Disease Severity

Cited by 81 publications

References 209 publications

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications

A circadian based inflammatory response – implications for respiratory disease and treatment

A Review of Polymeric Refabrication Techniques to Modify Polymer Properties for Biomedical and Drug Delivery Applications

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