Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein

Oh, Jun Ho; Park, Hyoun Hyang; Young, Ki; Han, Moon Gyu; Hyun, Dong Hun; Kim, Chang Gyu; Kim, Chang Hyeon; Lee, Seung S.; Hwang, Sung Joo; Shin, Sang Chul; Cho, Cheong-Weon

doi:10.1016/j.ejpb.2008.02.009

Cited by 115 publications

(60 citation statements)

References 22 publications

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“…In regards to the effect of MN interspacing upon the force required for MN insertion into skin, it was found that only the MN arrays with interspacing values ≤ 50 µm had a significantly different (p < 0.001) insertion force per MN, in comparison to the arrays of MN interspacing 150-600 µm. Whilst it has been shown that increasing the density of a MN array can led to an increase in the rate of transdermal drug delivery (Oh et al, 2008;Yan et al, 2010), it appears that there will be an optimum density for any given MN design and application (Widera et al, 2006;Verbaan et al, 2008;Yan et al, 2010). Yan et al, (2010) …”

Section: In Vitro Determination Of Insertion Force Required For Mn Pementioning

confidence: 99%

“…Recently, there has beenincreasing interest in investigating the influence of a variety of variables related to the use of MN, in order to reach an optimum MN design for transdermal drug delivery (Aggarwal et al, 2004;Davis et al, 2004;Verbaan et al, 2008;Olatunji et al, 2012). In particular it has been shown that the height and density of MNs on an array can affect the rate and extent of drug delivery achieved (Verbaan et al, 2008;Oh et al, 2008;Yan et al, 2010) including some of our previous work (Al-Qallaf et al, et al, 2007;Al-Qallaf and Das, 2008;Davidson, et al, 2008;Al-Qallaf and Das, 2009a,b;Al-Qallaf et al, et al, 2009a,b;Olatunji et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Olatunji

Das

Garland

et al. 2013

Journal of Pharmaceutical Sciences

200

132

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Section: In Vitro Determination Of Insertion Force Required For Mn Pementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Olatunji

Das

Garland

et al. 2013

Journal of Pharmaceutical Sciences

200

132

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“…3,11,27,28 Puncturing the SC allows efficient dermal/transdermal delivery of not only small compounds such as calcein, vitamin C, and ketoprofen, but also of large molecules including vaccines, gene vectors, and antibodies. In the case of lipophilic drugs, permeation is not a matter of concern for dermal delivery, because of their easier partitioning into the SC than that of other drugs.…”

Section: Discussionmentioning

confidence: 99%

Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

Lee¹,

Jeong²,

Lee³

et al. 2013

IJN

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Nanostructured lipid carriers (NLCs) were employed to formulate a lipophilic drug into hydrophilic polymeric microneedles (MNs). Hyaluronic acid (HA) was selected as a hydrophilic and bioerodible polymer to fabricate MNs, and nile red (NR) was used as a model lipophilic molecule. NR-loaded NLCs were consolidated into the HA-based MNs to prepare NLC-loaded MNs (NLC-MNs). A dispersion of NLCs was prepared by high-pressure homogenization after dissolving NR in Labrafil and mixing with melted Compritol, resulting in 268 nm NLCs with a polydispersity index of 0.273. The NLC dispersion showed a controlled release of NR over 24 hours, following Hixson–Crowell’s cube root law. After mixing the NLC dispersion with the HA solution, the drawing lithography method was used to fabricate NLC-MNs. The length, base diameter, and tip diameter of the NLC-MNs were approximately 350, 380, and 30 μm, respectively. Fluorescence microscopic imaging of the NLC-MNs helped confirm that the NR-loaded NLCs were distributed evenly throughout the MNs. In a skin permeation study performed using a Franz diffusion cell with minipig dorsal skin, approximately 70% of NR was localized in the skin after 24-hour application of NLC-MNs. Confocal laser scanning microscopy ( z -series) of the skin at different depths showed strong fluorescence intensity in the epidermal layer, which appeared to spread out radially with the passage of time. This study indicated that incorporation of drug-loaded NLCs into MNs could represent a promising strategy for controlled dermal delivery of lipophilic drugs.

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“…Likewise, formation of microneedles of calcein, insulin, erythropoietin and l-carnitine showed good bioavailability and stability (Table 3). [32,65,67,68] …”

Section: Bioactive Macromolecules (Biopharmaceuticals)mentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2012

Journal of Pharmacy and Pharmacology

357

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein

Cited by 115 publications

References 22 publications

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches

Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

Microneedles: an emerging transdermal drug delivery system

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