2007
DOI: 10.1038/sj.pcan.4501005
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Influence of the docetaxel administration period (neoadjuvant or concomitant) in relation to HIFU treatment on the growth of Dunning tumors: results of a preliminary study

Abstract: The objective of this study was to evaluate mechanisms of the synergy between high intensityfocused ultrasound (HIFU) and docetaxel and to determine the best sequence of chemotherapy administration in relation to HIFU treatment for obtaining optimum control of tumoral growth. A total of 15 days after s.c. implantation of the tumor, 52 Copenhagen rats studied were randomized in 4 groups of 13: controls, docetaxel alone (group 1), HIFU and docetaxel concomitant (group 2) and HIFU and docetaxel administered 24 h … Show more

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Cited by 17 publications
(15 citation statements)
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“…In several animal studies, CCHT induced apoptosis and it inhibited tumor growth more than chemotherapy or HIFU alone (10-12, 18). The mechanistic rationale for the inhibition of tumor growth by CCHT is based on the thermal and non-thermal effects of pulsed HIFU.…”
Section: Discussionmentioning
confidence: 99%
“…In several animal studies, CCHT induced apoptosis and it inhibited tumor growth more than chemotherapy or HIFU alone (10-12, 18). The mechanistic rationale for the inhibition of tumor growth by CCHT is based on the thermal and non-thermal effects of pulsed HIFU.…”
Section: Discussionmentioning
confidence: 99%
“…Paparel et al evaluated in a rat model the therapeutic effect of HIFU combined with docetaxel on AT2 Dunning adenocarcinoma [54,55]. They showed a synergistic inhibitory effect of the HIFU þ Docetaxel association.…”
Section: Chemotherapy Associated With Hifumentioning
confidence: 94%
“…Combination of HIFU with others treatment modalities is possible: high risk cancers have been treated with a combination of HIFU and androgen deprivation therapy [ 52 ], A synergistic effect has been shown when using docetaxel in a neoadjuvant form just before HIFU in agressive tumors such as Dunning model [ 53 ].…”
Section: Future Of Hifumentioning
confidence: 99%