Influence of the drug of sodium diclofenac in a dose dl100 and dl50 on mechanisms of differentiation of cells of red bone marrow cells of rats in vitro

Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

“…Currently, many scientists have begun to consider OA as a metabolic and as a calcium-deficient disease [ 1 , 20 , 21 , 22 , 23 ]. In OA, there are violations of the synthetic activity of chondrocytes (ultrastructural changes); decreased hydrophilicity of cartilage; slow degeneration, and a decrease in the number of chondrocytes occur, which leads to the loss of normal biomechanical properties by the cartilage matrix [ 4 ].…”

“…For example, nutraceutical products made from green tea include green tea powder, green tea extract, and concentrated epigallocatechin-3-gallate (EGCG) derived from green tea. Since ancient times, turmeric and ginger have been used in India and China to treat OA, in particular, to treat pain in OA [ 22 , 23 ]. New Zealand has a centuries-old practice of using green lip mussels for the same purpose [ 29 ].…”

“…Among the side effects noted: moderate local pain from a needle stick for several days after the procedure; increased pain in the patient immediately after the injection and its preservation after that; a slight aggravation of the process after the initial improvement (usually by the 2nd or 3rd day) followed by a good regression by the 7th day. According to the authors of the study, the varying severity of these manifestations is a heterogeneous picture of one pathogenetic state in people in the acute period of the disease with severe pain—the presence of acute inflammatory changes in the tissues [ 14 , 23 , 24 ]. It is known that HA metabolites under conditions of a pronounced inflammatory process possess not anti- but pro-inflammatory activity and can cause exacerbation [ 33 ].…”