In this paper, a new modelling approach is proposed for the dynamic investigation of epicyclic gear train, and the novelty of this work lies in consideration of both structural flexibility and mechanical interactions during the analysis procedure. The method is of capacity to directly present the dynamic results of the supporting structure for convenient practical engineering evaluation and reduce the dimension of the system reasonably with appropriate assumptions for better computational efficiency. Firstly, the mechanical interactions among components are discussed in detail, and the principle that the structural flexibility works is also explained at length. Secondly, taking the epicyclic gear train of the geared turbofan (GTF) engine; for example, the dynamic model of the system is then established based on the developed hybrid user-defined elements. For model validation, the governing equations of the system are also derived by the lumped mass method. Thirdly, with the same values of the parameters, the results of normal dynamic meshing force obtained by the proposed model are compared with the ones by the lumped mass model. It can be stated from the data that (1) the maximum relative error between the theoretical value and the average value calculated by the two models is 8.28%, (2) the gear mesh frequency obtained by the two models are sufficiently close to the theoretical value, and (3) the fluctuation trends of the dynamic force keep basically consistent with each other. In summary, the comparison presented clearly indicates that the proposed model is indeed reasonable, which provides a new way for dynamic investigation and structural redesign of a large epicyclic gear train. Finally, as a practical engineering application, the vibration result of the deformable supporting structure of the GTF gear train is also presented, which directly provides valuable reference for vibration monitoring, fault diagnosis and other engineering problems in practice.