Influence of the Environmental Isotope Composition Modification on Growth and Metabolic Activity of Rhodococcus and Saccharomyces

Volchenko, N. N.; Samkov, A. A.; Малышко, В. В.; Khudokormov, A. A.; Моисеев, А. В.; Елкина, А. А.; Барышев, М. Г.; Першин, С. М.

doi:10.1134/s1062359020040135

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The deuterium concentration in the body plays an important role in the metabolic processes of living systems [1][2][3][4]. The biological effects caused by deuterium depleted water (DDW) have been studied at various levels: cellular [5][6][7][8], tissue [9], organismic [10][11][12][13][14]. It was found that low concentrations of deuterium in the drinking diet increase stress resistance in mammals [15], and may also have neuroprotective properties [16].…”

Section: Introductionmentioning

confidence: 99%

Inequality in the Frequency of the Open States Occurrence Depends on Single 2H/1H Replacement in DNA

et al. 2020

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In the present study, the effect of 2H/1H isotopic exchange in hydrogen bonds between nitrogenous base pairs on occurrence and open states zones dynamics is investigated. These processes are studied using mathematical modeling, taking into account the number of open states between base pairs. The calculations of the probability of occurrence of open states in different parts of the gene were done depending on the localization of the deuterium atom. The mathematical modeling study demonstrated significant inequality (dependent on single 2H/1H replacement in DNA) among three parts of the gene similar in length of the frequency of occurrence of the open states. In this paper, the new convenient approach of the analysis of the abnormal frequency of open states in different parts of the gene encoding interferon alpha 17 was presented, which took into account both rising and decreasing of them that allowed to make a prediction of the functional instability of the specific DNA regions. One advantage of the new algorithm is diminishing the number of both false positive and false negative results in data filtered by this approach compared to the pure fractile methods, such as deciles or quartiles.

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