Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation

The influence of hepatitis C virus genotypes on the outcome of liver transplantation

“…The discordance between the conclusions of our analysis and those reported by Feray et al 14 in France and Gane et al 15 in England is not easy to explain. Nevertheless, there are several significant differences between the studies.…”

“…[7][8][9][10] A reliable prediction of the posttransplantation course, critical in the face of the nationwide donor organ shortage, has proved to be elusive, with different groups reporting the purported prognostic value of viral load, 11 HLA matching, 12,13 or viral genotypes. 14,15 However, because these findings are contradicted by other studies, 16,17 there is little consensus as to which parameters are important in predicting the outcome of liver transplantation.…”

Hepatitis C viral infection in the immunosuppressed patient

“…As in immunocompetent patients 35 viral genotype 1b has been associated with a severe outcome 36 following liver transplantation. However, it is possible that the association between genotype 1b and the severe posttransplant liver disease, as reported by Feray et al, is only a reflection of the high prevalence of type 1b in their study population.…”

Do viral genotypes and HLA matching influence the outcome of recurrent hepatitis C virus infection after liver transplantation?

“…28,29 The impact of HCV genotype on the outcome of recurrent liver disease after transplantation is similarly unresolved. Several groups have suggested that infection with HCV genotype 1b is associated with a higher recurrence rate 21 and more severe posttransplantation hepatitis. 22,23 However, a large study based on patients in a major liver center in the United States did not confirm this association 10 24 In this large series of patients, most of whom developed chronic hepatitis within 5 years of follow-up, the authors found no correlation between HCV genotypes and the outcome of recurrent posttransplantation hepatitis as measured by overall patient survival, liver disease-free interval, and severity of histological disease.…”