Influence of the level of blood pressure on the regulatory-adaptive state

Pokrovskii, V. M.; Kompaniets, O. G.

doi:10.1134/s036211971204010x

Cited by 4 publications

(6 citation statements)

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“…The patients with hypertension had a lower level of regulatory and adaptive status before the treatment in comparison with the control group (iRAS was by 46.5% lower), which is consistent with the previous data (Pokrovskii and Kompaniets 2012). As a result of the six-month therapy against the background of achieving the target BP values, the integrative indicator iRAS increased in the treatment with the lisinopril/indapamide combination (by 40.5%), amlodipine (by 40.5%), losartan (by 35.3%), and lisinopril (by 30.2%).…”

Section: Disorders Of Bp Regulation System Mechanisms At the Integratsupporting

confidence: 91%

“…The possibility of such an assessment for the BP regulation system is discussed in (Pokrovskii and Kompaniets 2012). The examination by using the method of cardiorespiratory synchronism was performed using a software and hardware complex, including a VNS-Micro unit providing a synchronous recording of ECG and pneumogram, and original software for implementing a signal generating algorithm, setting the respiratory rate, recording the onset of cardiorespiratory synchronization and its parameters, and for calculating the index of regulatory and adaptive status (iRAS) by the following formula: iRAS = (synchronization range / synchronization period at the minimum range) × 100 (Pokrovskii and Polischuk 2016).…”

Section: A Quantitative Assessment Of Beta-adrenoreceptionmentioning

confidence: 99%

“…The reason seems to be the absence of methodological approaches providing a quantitative assessment of the integrative regulation level in hypertension (Pokrovskii and Polischuk 2016). This approach is declared in the study (Pokrovskii and Kompaniets 2012), which focuses on the inverse relationship between a hypertension degree and a level of regulatory and adaptive status determined by the method of cardio-respiratory synchronism. At the same time, the integrative level has not been considered in combination with other levels of BP regulation yet.…”

Section: Introductionmentioning

confidence: 99%

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Complex assessment of blood pressure regulation system in hypertension patients

Samorodskaya¹,

Polischuk²,

Елисеева³

2019

RRP

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Introduction. There are almost no studies characterizing the integrative level of blood pressure (BP) regulation. Materials and methods. 277 people of both genders aged 58.6±6.4 with stage II hypertension disease were randomized into six groups. The monotherapy of hypertension disease was conducted in five groups, using nebivolol, lisinopril, indapamide, amlodipine, and losartan. The sixth group had a combined therapy (lisinopril/indapamide). The therapy effectiveness was assessed at four levels of blood pressure regulation, using the following methods: 1) laser Doppler flowmetry, determination of the level of tumor necrosis factor-α and interleukin-10; 2) echocardiography and Doppler sonography, ultrasound examination of the renal blood flow, ECG, Holter monitoring of ECG; 3) an examination of the heart rate variability level and a quantitative assessment of beta-adrenoreception of erythrocyte cell membranes; 4) the regulatory and adaptive status was assessed, using the method of cardio-respiratory synchronism. Results and discussion. A more significant BP decrease was revealed during a combination therapy (by 20.4% of the baseline daily value). At the integrative level, an index of the regulatory and adaptive status (iRAS) increased in the treatment with lisinopril/indapamide combination (by 40.5%), amlodipine (by 40.5%), losartan (by 35.3%), and lisinopril (by 30.2%). Nebivolol administration resulted in a 13.5% decrease in iRAS. Indapamide therapy had no significant effect on iRAS. Conclusion. A comprehensive assessment of the blood pressure regulation system makes it possible to control the effectiveness of the therapy not only on a target organ or function, but also on the condition of the organism as an integral system.

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Section: Disorders Of Bp Regulation System Mechanisms At the Integratsupporting

confidence: 91%

Section: A Quantitative Assessment Of Beta-adrenoreceptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complex assessment of blood pressure regulation system in hypertension patients

Samorodskaya¹,

Polischuk²,

Елисеева³

2019

RRP

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“…Определение нарушений механизмов системы регуляции АД на уровне интегративного обеспечения. Был использован анализ РАС методом СДС на приборе «ВНС-Микро» (ООО «Нейрософт», Россия) с вычислением индекса РАС (ИРАС) по формуле [14]: ------------------------------------. длительность развития синхронизации на минимальной границе диапазона × 100 В зависимости от величины ИРАС выделяли: низкий уровень РАС (ИРАС<30), средний уровень РАС (ИРАС от 31 до 59), высокий уровень РАС (60,0<ИРАС), что сделало возможным объективно-количественную оценку регуляторно-адаптивных изменений организма [10,14].…”

Section: определение нарушений механизмов системы регуляции ад на уро...unclassified

“…Причина, по-видимому, связана с отсутствием методических подходов, обеспечивающих количественную оценку состояния интегративного уровня регуляции при артериальной гипертензии (АГ) [9]. Этот подход декларирован в исследовании [10], в котором показана обратная зависимость между степенью АГ и уровнем регуляторно-адаптивного статуса (РАС), определяемом методом сердечно-дыхательного синхронизма (СДС). При этом в комплексе с другими уровнями регуляции АД интегративный уровень еще не рассматривался.…”

Section: Introductionunclassified

Hierarchical organization of the blood pressure regulation system in the human body

Покровский¹,

Елисеева²,

Самородская³

2021

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Цель исследования - создание на основе анализа нарушений механизмов системы регуляции артериального давления (АД) нового методологического подхода в определении эффективности антигипертензивной терапии у пациентов с гипертонической болезнью. Методика. В исследование включены данные 277 пациентов (136 мужчин, 141 женщина) с гипертонической болезнью II стадии 1-2 степени, риск II, III. Возраст пациентов 58,6±6,4 лет, давность заболевания 7,2±1,4 лет. В группу контроля вошли 57 практически здоровых лиц (25 женщин, 32 мужчины) в возрасте 52,1±4,4 года. После скрининга и получения письменного информированного согласия в виде монотерапии назначены: небиволол, лизиноприл, лозартан, индапамид, амлодипин, и нефиксированная комбинация лизиноприла и индапамида. Изучены изменения показателей АД на выделенных уровнях системы регуляции АД после 6 мес терапии. Результаты. Оценка эффективности применяемой терапии показала, что при стабилизации артериального давления у пациентов всех 6 групп на должном уровне существенные различия выявлены на интегративном уровне регуляции. При применении амлодипина, лозартана, лизиноприла, а также комбинации лизиноприла и индапамида регуляторно-адаптивные возможности организма улучшились, при лечении индапамидом - не изменились, при применении небиволола снизились. Предложена оригинальная классификация уровней регуляции (контроля) артериального давления у человека, основанная на общебиологическом принципе иерархической организации регуляции вегетативных функций. Выделены уровни: интегративный, вегетативного обеспечения (осуществляемый автономной нервной системой), органный, периферический (эндотелиально-микроциркуляторный). Заключение. Количественная оценка на интегративном уровне является универсальным показателем эффективности лечения, что открывает возможность создания методологического подхода, основанного на оценке влияния терапевтических воздействий не только на орган- или функцию-мишень, но и на состояние организма как целостной системы. Aim. To create a new methodological approach for determining the effectiveness of antihypertensive therapy in patients with arterial hypertension based on the analysis of violation of mechanisms in the blood pressure (BP) regulation system. Methods. This study included 277 patients (136 males, 141 females) with stage II, grade 1-2 hypertension, risk II, III, aged 58.6±6.4 yrs, with disease duration 7.2±1.4 yrs. The control group included 57 essentially healthy individuals (25 females, 32 males) aged 52.1±4.4 yrs. After screening and obtaining written informed consent, the following monotherapy was prescribed: nebivolol, lisinopril, losartan, indapamide, and amlodipine, plus an unfixed combination of lisinopril and indapamide. Changes in BP indexes at the predetermined levels of the BP regulation system were studied after 6 mos. of treatment. Results. Evaluation of the therapy effectiveness showed that, when BP was stabilized in all six groups at proper values, significant differences were revealed at the integrative regulatory level. When patients were treated with amlodipine, losartan, lisinopril, as well as a combination of lisinopril and indapamide, the regulatory and adaptive capabilities of the body improved. When treated with indapamide, these capabilities were unchanged, and when treated with nebivolol, these capabilities decreased. A new classification of the regulatory levels of BP control in humans is proposed. This classification is based on the general biological principle of hierarchical organization for the regulation of autonomic functions. The following levels are distinguished: integrative, autonomic support, i.e., carried out by the autonomic nervous system, organ, and peripheral, i.e., endothelial-microcirculatory. Conclusion. Quantitative assessment at the integrative level is a universal indicator of the treatment effectiveness. It makes it possible to create a methodological approach to determine possible effectiveness of treatment based on the assessed impact not only on the target organ or function, but also on the status of the body as a whole system.

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The functional state of students depending on the ethno-territorial factor

Ivanyshyn

Vypasniak

Єрмаков

et al. 2022

PES

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Background and Study Aim. Integration processes in education provide for increased mobility of students from different countries. The related change in environmental parameters, cultural and social standards require additional tension in the work of regulatory mechanisms. This can lead to exhaustion of the body's reserve capabilities, disruption of adaptation and loss of health. The purpose of the work is to investigate the ethno-territorial variability of the functional state and adaptation potential of foreign students studying at Ukrainian universities. Material and Methods. Students of the medical university (n = 488, age 18–25) who came to study in Ukraine from different countries took part in the study. Data were obtained from cross-sectional surveys from 2014 to 2019. Anthropometric measures included body length (LT), body mass (MT). Functional status was assessed by Robinson, Rufier, vital capacity and strength indices. Adaptation capabilities and the level of physical condition of students were also determined. Experimental data were processed using the SPSS program. Results. It was established that the vast majority of students had Robinson index values: low and below average (students from Poland, Bulgaria, Jordan, Egypt); below average level (students from Ukraine, Malaysia and Tunisia); medium (students from India and China). Students from Poland, Jordan and Egypt are characterized by the lowest vital capacity index (52.7 – 54.9 ml·kg-1). Among the residents of India and China there were the most students with above average and high levels of vital capacity index. Most of the students (with the exception of students from Malaysia and Egypt) had a power index at the level of average and above average. The Ruffier index for students was: weak level – students from Poland, Bulgaria, Egypt and Jordan; satisfactory level – students of Tunisia, Ukraine, India and Malaysia; moderate level – students from China. The majority (40–44%) of the examined contingent from Poland, Bulgaria and Jordan was in a pre-diagnostic state. There were14–27% of such students among students from Egypt, China, India and Tunisia. There were about 10% of such students among Ukrainian students. From 6% to 11% of all foreign students were in a pre-morbid state. This condition is characterized by a decrease in the functional reserves of the circulatory system. Among Ukrainian students, there were 2.04% of such students. From 2.44% to 7.69% of foreign students had asthenization of regulatory systems; such a state was not observed among Ukrainian students. Conclusions. The obtained results of the study expand the data on the peculiarities of the physiological state of students of foreign countries and their adaptation capabilities. It is important that students with strained adaptation mechanisms or an unsatisfactory level of adaptation are able to reveal high functional capabilities with individualized physical exercises. An unsatisfactory state of functional systems can stimulate students to increase the body's adaptive resources. This contributes to increasing the level of motor activity and improving physical education courses with training according to an individualized educational program.

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Influence of the level of blood pressure on the regulatory-adaptive state

Cited by 4 publications

References 9 publications

Complex assessment of blood pressure regulation system in hypertension patients

Complex assessment of blood pressure regulation system in hypertension patients

Hierarchical organization of the blood pressure regulation system in the human body

The functional state of students depending on the ethno-territorial factor

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