2020
DOI: 10.1038/s41598-020-66412-z
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Influence of the long-term use of oral hygiene products containing stannous ions on the salivary microbiome – a randomized controlled trial

Abstract: Oral hygiene products containing tin are suitable to prevent erosive tooth wear, yet effects on the oral microbiota are not known yet. Therefore, this study determined the salivary microbiome of 16 participants using products with stannous ions for three years (TG) compared with a control group (CG) to assess their influence on the microbiota. Participants were included in a randomized controlled clinical trial (RCT) with biannual visits. Illumina Miseq sequencing revealed as most abundant genera: Streptococcu… Show more

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Cited by 13 publications
(14 citation statements)
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“…Intergroup differences, measured via the difference between T0 and T1, were found for Gram-negative bacteria, black-pigmented bacteria and Gram-negative anaerobic rods, with an increase in the control group compared to the test group. This confirms the findings of the Illumina Miseq Sequencing in another investigation of this study series [ 14 ]. Some Prevotella spp.…”
Section: Discussionsupporting
confidence: 92%
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“…Intergroup differences, measured via the difference between T0 and T1, were found for Gram-negative bacteria, black-pigmented bacteria and Gram-negative anaerobic rods, with an increase in the control group compared to the test group. This confirms the findings of the Illumina Miseq Sequencing in another investigation of this study series [ 14 ]. Some Prevotella spp.…”
Section: Discussionsupporting
confidence: 92%
“…This hypothesis is supported by the significant increase in diversity in the test group, which appears to be related to oral health [ 35 ]. In contrast to these findings, the Illumina Miseq sequencing showed no differences for either alpha-diversity or beta-diversity between the test and control groups [ 14 ]. It should be emphasized that up to 50% of oral bacteria cannot be isolated using the culture technique, as was shown using the culture-independent 16S-rDNA cloning technique [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
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“…All BRONJ patients had periodontal disease; which is the main risk for osteonecrosis identified in our study. This level of periodontal disease is expected in the age group of this study population ( 18 , 19 ).…”
Section: Discussionsupporting
confidence: 54%
“…Zinn weist zudem antibakterielle Effekte auf. Sogar bei Langzeitanwendung über mehrere Jahre wirkte es insgesamt eher stabilisierend auf die bakterielle Besiedelung der Mundhöhle, hin zu einer Mikroflora, die gesunden Verhältnissen entspricht[32]. Die Verträglichkeit der Produkte ist insgesamt gut, somit können zinnhaltige Produkte ohne Bedenken auch zur Langzeitanwendung empfohlen werden.Polymere als antierosive WirkstoffeZahnpasten sind sehr komplex formulierte Gemische verschiedener Wirk-und Hilfsstoffe; sie zeigen oft eine sehr große Spannbreite in der Wirksamkeit.…”
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