Influence of the MCT1 rs1049434 on Indirect Muscle Disorders/Injuries in Elite Football Players

Massidda, Myosotis; Eynon, Nir; Bachis, Valeria; Corrias, Laura; Culigioni, Claudia; Piras, Francesco; Cugia, Paolo; Scorcu, Marco; Calò, Carla Maria

doi:10.1186/s40798-015-0033-9

Cited by 46 publications

(65 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table summarizes the substrate specificity, tissue localization, and the potential clinical relevance for the MCT isoforms. It is important to note that the discrepancy between MCT isoform number and SLC16A nomenclature evolved from the order in which each cDNA sequence was determined and characterized .…”

Section: Structure Function Substrate Specificity and Regulationmentioning

confidence: 99%

“…One of the most commonly studied polymorphic variants of MCT1 is the MCT1-T1470A polymorphism (rs1049434), which has been previously suggested to influence changes in blood lactate concentrations during weight training and muscle injury in football players. 22,23 This single nucleotide polymorphism results in the conversion of aspartic acid to glutamic acid at the 490 position, and patients carrying the T-allele exhibited a reduction of 35-40% in erythrocyte lactate transport rate. 21 Although this reduction is large, more extensive studies are required to determine the clinical utility of this variant.…”

Section: Mct1mentioning

confidence: 99%

See 1 more Smart Citation

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Jones

Morris

2016

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

Solute carrier (SLC) transporters represent 52 families of membrane transport proteins that function in endogenous compound homeostasis and xenobiotic disposition, and have been exploited in drug delivery and therapeutic targeting strategies. In particular, the SLC16 family that encodes for the 14 isoforms of the monocarboxylate transporter (MCT) family plays a significant role in the absorption, tissue distribution, and clearance of both endogenous and exogenous compounds. MCTs are required for the transport of essential cell nutrients and for cellular metabolic and pH regulation. Recent publications have indicated their novel roles in disease, and thus their potential as biomarkers and new therapeutic targets in disease are under investigation. More research into MCT isoform function, specificity, expression, and regulation will allow researchers to exploit the potential utility of MCTs in the clinic as therapeutic targets and prognostic factors of disease.

show abstract

Section: Structure Function Substrate Specificity and Regulationmentioning

confidence: 99%

Section: Mct1mentioning

confidence: 99%

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Jones

Morris

2016

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

show abstract

“…Among the studied genetic variants there is a common A1470T (Glu490Asp) polymorphism (rs1049434) that has been associated with athletic performance [17,24,41], injuries and body composition in football players [27,28]. This variant leads to the replacement of glutamic acid with aspartic acid in the MCT1 gene (also known as SLC16A1; location: 1p12) [34].…”

Section: Introductionmentioning

confidence: 99%

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

et al. 2018

Self Cite

View full text Add to dashboard Cite

The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n=694) and non-athlete controls (n=781) from Italy, Poland, Lithuania, Ukraine and Malta, and we analyzed the MCT1 genotype distributions with respect to the players’ positions in the field (e. g. forwards, midfielders, defenders and goalkeepers). Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards (n=148) were more likely than controls (n=781) to possess the A allele (χ2=7.067, p=0.029, FDR q value 0.116), with a greater likelihood of having the AA genotype compared with the TT genotype (OR=1.97; C.I.=1.07-3.64; p=0.021, FDR q value 0.086). The MCT1 AA genotype was significantly more frequent in forwards then in controls. Further studies are needed to confirm these findings in other professional football player cohorts.

show abstract

“…The protein expressed from the PPARG gene plays a role in the transcriptional processes regulating adipocyte differentiation, lipid storage, fat-specific gene expression and insulin signaling (Auwerx 1999;Lehrke and Lazar 2005;Meirhaeghe and Amouyel 2004). MCT1 is a membrane transporter which symports a proton together with a monocarboxylate molecule such L-lactate, pyruvate or the ketone bodies beta-hydroxybutyrate and acetoacetate (Poole and Halestrap 1994), and lately it has been mentioned in relation to obesity and body composition (Carneiro and Pellerin 2015;Massidda et al 2015).…”

Section: Do Common Polymorphisms Influence Body Weight and Fat Regainmentioning

confidence: 99%

“…Furthermore, these in vivo results have recently been confirmed when oocytes expressing the Asp490 allele showed a lower lactate uptake (Sasaki et al 2015). Regarding the above mentioned relation of MCT1 with energy metabolism and body composition, the cited SNP has been also related with body composition in athletes, observing a higher fat-free mass percentage in Asp490Asp or Asp490 carriers soccer players compared to Glu490Glu players (Massidda et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Influence of diverse genetic polymorphisms on body weight and body composition during a weight loss program

Szendrei¹

View full text Add to dashboard Cite

Nuestros resultados sugieren que algunos de estos polimorfismos pueden afectar el peso corporal y la composición corporal durante una intervención de pérdida de peso y durante el seguimiento posterior de 3 años, sin embargo estos efectos no son determinantes y deben ser replicados. Ideogram of human karyotype with loci for Prader-Willi Syndrome (PWS), Albright hereditary osteodystrophy (AHO), Bardet-Biedl Syndrome (BBS) (green line), monogenic mutations (green triangle), selected obesity candidate genes (red triangle) and QTLs identified by genome-wide linkage scans (red line) Source: (Loos and Bouchard 2003) Each point represents one pair of twins (A and B). The closer the points are to the diagonal line, the more similar the twins are to each other. Source: (Bouchard et al. 1990) In a subsequent study of Bouchard et al. seven male identical twin pairs completed a 93 day negative energy balance program with exercise. In weight loss (mean 5.0 kg; equal fat loss as fat free mass was unchanged) there were large individual differences Figure 6. Similarity within pairs with respect to decrease in body weight (left) and body fat (right) in 14 pairs of obese twins Source: (Hainer et al. 2000) Bouchard also suggested that the heterogeneity of responsiveness to regular exercise (not everybody responds the same way/ same equally to exercise or any environmental impact) is trait specific. In other words, someone who is low responder stimulating hormone) (Strobel et al. 1998). Leptin expression is increased by overfeeding, insulin, glucocorticoids, endotoxin and cytokines and is decreased by fasting, testosterone, thyroid hormone and exposure to cold temperature (Yang and Barouch 2007; Fried et al. 2000). However, acute changes in food intake do not induce short-term increases in plasma leptin levels (Jequier 2002; Considine et al. 1996), in contrast to rodents, where leptin gene expression is stimulated by eating and leptin administration acutely reduces food intake (Campfield less final percentage fat than Glu490 carriers (p=0.025, 1.94%). Finally, interaction with sex and exercise was seen for percentage FFM, among women the Asp490Asp group ended up with higher values than Glu490 carriers (p=0.005, 2.76%). Conclusions Our results uncover a possible influence of the Glu490Asp polymorphism of the MCT1 gene on body composition responses. It seems that the absence of the Glu40 allele implies less weight, BMI and percentage fat at the end of the program, especially in non-supervised women. However, further studies are necessary to confirm these results and clarify the underlying mechanisms.

show abstract

Influence of the MCT1 rs1049434 on Indirect Muscle Disorders/Injuries in Elite Football Players

Cited by 46 publications

References 34 publications

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

Influence of diverse genetic polymorphisms on body weight and body composition during a weight loss program

Contact Info

Product

Resources

About