Influence of the Mediterranean diet on carotid intima–media thickness in hypercholesterolaemic children: A 12-month intervention study

Giannini, Cosimo; Diesse, Laura; D'Adamo, Ebe; Chiavaroli, Valentina; Giorgis, Tommaso de; Iorio, Cesare Di; Chiarelli, Francesco; Mohn, Angelika

doi:10.1016/j.numecd.2013.04.005

Cited by 54 publications

(43 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results have been previously reported in obese children and adolescents following a hypocaloric diet low in simple carbohydrates and high in vegetables and fiber-rich cereals [43]. Other authors have reported in children with hypercholesterolemia decrease in TC and LDL-C levels with a Mediterranean diet [45]. …”

Section: Discussionsupporting

confidence: 88%

Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity

et al. 2014

View full text Add to dashboard Cite

BackgroundThe beneficial effects of the Mediterranean diet have been amply proven in adults with cardiovascular risk factors. The effects of this diet have not been extensively assessed in pediatric populations with obesity, insulin resistance (IR) and metabolic syndrome (MetS). The aim of this study was to assess the efficacy of the Mediterranean style diet (MSD) to decrease cardiovascular risk factors in children and adolescents with obesity.MethodsParticipants were randomly assigned to a MSD rich in polyunsaturated fatty acids, fiber, flavonoids and antioxidants (60% of energy from carbohydrate, 25% from fat, and 15% from protein, (n = 24); or a standard diet (55% of carbohydrate, 30% from fat and 15% from protein, (n = 25), the caloric ingest was individualized. At baseline and 16-week of intervention, the glucose, triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C were measured as well as the body composition and anthropometric data. The diet compliance was determined by the 24-hour recalls.Paired Student’s t and Macnemar’s test were used to compare effects in biochemical, body composition, anthropometric, and dietary variables.ResultsThe MSD group had a significantly decrease in BMI, lean mass, fat mass, glucose, TC, TG, HDL-C and LDL-C. (p < 0.05); the diet compliance increased consumption of omega 9 fatty acids, zinc, vitamin E, selenium, and decreased consumption of saturated fatty acids (p < 0.05). The standard diet group decrease in glucose levels and frequency of glucose >100 mg/dL (p < 0.05).ConclusionThe MSD improves the BMI, glucose and lipid profile in children and adolescents with obesity and any MetS component.

show abstract

Section: Discussionsupporting

confidence: 88%

Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Although associations with CIMT have not been assessed previously, dietary pulse intake has been associated with reduced risk of CHD and CVD,19 20 which supports the association found in the current study between dietary pulse intake and CIMT as a subclinical marker of CVD risk. Additionally, dietary pulses are part of a Mediterranean diet and this diet has been associated with improved CIMT in a number of studies,16 44–46 as was highlighted in a recent systematic review of dietary factors and CIMT by Petersen et al 47. We also found dietary pulse intake to be significantly associated with lower body weight, systolic and diastolic blood pressure, mean arterial pressure and cholesterol (see online supplementary table S1).…”

Section: Discussionsupporting

confidence: 63%

Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes.DesignCross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way.SettingRisk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada.Participants325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event.Main outcome measuresCIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples.ResultsCIMT was significantly inversely associated with dietary pulse intake (β=−0.019, p=0.009), available carbohydrate (β=−0.004, p=0.008), glycaemic load (β=−0.001, p=0.007) and starch (β=−0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer.ConclusionsLower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further.Trial registration numberNCT01063374.

show abstract

“…Dyslipidemia is an independent risk factor in the development of atherosclerosis, and the hyperlipidemic status has been shown to be related to an increase in cIMT (21). This relationship is known to be more evident based on familial hypercholesterolemia (22,23). In studies that have evaluated the relationship between cIMT and cholesterol sub-types, the LDL cholesterol (LDL-C) concentrations have been reported to be related to an increase in cIMT (24,25), and an increase in HDL cholesterol has been reported to have a positive effect (26).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

et al. 2018

View full text Add to dashboard Cite

Objectives:The aim of this study was to evaluate the effects of the change in the body mass index following laparoscopic sleeve gastrectomy on the vascular morphology structure and biochemical and hemocytic parameters. Material and Methods:A prospective evaluation of 60 patients who underwent sleeve gastrectomy was conducted. The relationship was evaluated between the vascular morphological parameters and biochemical and hemocytic inflammatory variables of the patients preoperatively and at 6, 12, and 18 months postoperatively.Results: Compared to the baseline values, a significant decrease was determined in the carotid intima media thickness at 6, 12, and 18 months (p<0.001, p<0.001, p<0.001, respectively). The compliance and distensibility values were observed to increase over time (p<0.05, p<0.001, p<0.001, respectively). A statistically significant difference was determined in the carotid intima media thickness values according to gender, with males (n:7) measuring 0.618±0.123 mm and females (n:53) measuring 0.506±0.113 mm (p<0.01). When patients were grouped as neutrophil-to-lymphocyte ratio ≤2.54 (n:41) and neutrophil-to-lymphocyte ratio>2.55 (n:19), the increasing neutrophil-to-lymphocyte ratio values were observed to be in proportion to the carotid intima media thickness, and the difference was statistically significant (p<0.001). When factors affecting the vascular morphology parameters measured at baseline and throughout the study were evaluated with the correlation analysis, there was observed to be a positive correlation between the baseline carotid intima media thickness thickness and neutrophil percentage (r=0.736, p<0.001) and neutrophil-to-lymphocyte ratio (r=0.676, p<0.001), and between the negative correlation and lymphocyte percentage (r=−0.628, p<0.001). Conclusion:Laparoscopic sleeve gastrectomy is not only a cosmetic procedure reducing the body mass index values, but it also has a beneficiary effect on vascular morphology, biochemical, and hemocytic parameters.

show abstract

Influence of the Mediterranean diet on carotid intima–media thickness in hypercholesterolaemic children: A 12-month intervention study

Cited by 54 publications

References 35 publications

Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity

Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity

Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial

Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

Contact Info

Product

Resources

About