Influence of the menopause and aging on spinal density in French women

Ribot, C.; Trémollières, Florence; Pouillès, J. M.; Jp, Louvet; Guiraud, R.

doi:10.1016/0169-6009(88)90009-8

Cited by 59 publications

(25 citation statements)

References 14 publications

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“…Rubin and Lanyon 32 have reported that an increased mechanical load resulted in remodeling of bone, and cortical thickness increase in tubular bone of obese adults. 1,3,33,34 The increased body fat and the decreased ash content of cortical bone in DIO rats, may have led to a compensatory mechanism to produce increased cortical thickness and area. A signi®cant positive correlation has been demonstrated between body fat and total mineral content.…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary-induced obesity on the biomechanical properties of femora in male rats

et al. 1998

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OBJECTIVE: To assess the effects of diet-induced obesity (DIO), on the biomechanical and biochemical properties of the femur in mature male rats. DESIGN AND SUBJECTS: Two groups of male rats were studied. The DIO experimental group was fed a high caloric diet and a 31% sucrose solution as drinking¯uid for a month, whereas the control group was fed lab chow and tap water. MEASUREMENT: Body weight; body water; lean body mass; femoral length; average cortical thickness; outer anteroposterior diameter; outer mediolateral diameter; cortex area; moment of inertia; cortical and cancellous bone hydration; tendon and muscle hydration; ash content of cortical and cancellous bone; ultimate load; de¯ection at ultimate load; ultimate strength; stiffness; elastic modulus and energy absorption capacity. RESULTS:`Gainers' (®nal body weight in excess of three standard error of mean of the controls) were 19.1% heavier, with higher body fat, whereas body water, lean body mass, hydration of cancellous bone and ash content of cortical bone were lower, when compared to controls. Rats that failed to gain weight, despite the high caloric diet, were termed`resisters' (weight gain less than three standard error of mean of the controls).Ultimate load, de¯ection at ultimate load and femoral energy absorption capacity were signi®cantly higher in the experimental group when compared to the controls. However, no differences were found among the groups with respect to ultimate stress and stiffness. CONCLUSION: The weight gain produced by DIO may lead to bone adaptation and improved biomechanics.

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Section: Discussionmentioning

confidence: 99%

The effects of dietary-induced obesity on the biomechanical properties of femora in male rats

et al. 1998

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“…This may also explain why shortly after menopause, obese women do not lose bone as rapidly as their non-obese counterparts. 126,127 A second mechanism relates to the increased mechanical load that heavier individuals place on weight-bearing bones. This is supported by some data suggesting that body size is a better determinant in weight bearing rather than non-weightbearing sites.…”

Section: -120mentioning

confidence: 99%

The impact of obesity on the musculoskeletal system

et al. 2007

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Obesity is associated with a range of disabling musculoskeletal conditions in adults. As the prevalence of obesity increases, the societal burden of these chronic musculosketelal conditions, in terms of disability, health-related quality of life, and health-care costs, also increases. Research exploring the nature and strength of the associations between obesity and musculoskeletal conditions is accumulating, providing a better understanding of underlying mechanisms. Weight reduction is important in ameliorating some of the manifestations of musculoskeletal disease and improving function.

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“…Estrogen deficiency during In 1941, Albright et al [1] first detected that menopause causes rapid bone loss, estrogen deficiency is a major pathogenic especially in the early years after menopause. Hui et al [2] (Indianapolis), Ribot et al [3] Department of Biotechnology, Sri Venkateswara (France), Hedlund and Gallagher [4] (Omaha, that the early hormone-dependent bone loss commences in the first year after menopause and is arrested within 6 years after the onset of menopause. In a recent study, GarciaPerez et al [6] obser ved elevated bone resorption marker levels in Spanish women of <2 YSM group compared to >2 YSM group.…”

Section: Introductionmentioning

confidence: 99%

Influence of years since menopause on bone mineral metabolism in South Indian women

Suresh

Naidu

2006

Indian J Med Sci

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BACKGROUND: Although an increase of bone turnover has been documented at the time of menopause, the subsequent abnormalities of bone resorption and formation in the elder women have not been investigated. AIM: To assess bone turnover among different YSM (years since menopause) groups of postmenopausal women. SETTINGS AND DESIGN: A case control study in a tertiary care hospital. MATERIALS AND METHODS: Forty-seven premenopausal (control) women and 257 postmenopausal women were included in this study. Based on YSM, the postmenopausal women were divided into four groups namely, 1-5 YSM (n=82), 6-10 YSM (n=77), 11-15 YSM (n=58) and >15 YSM (n=40). The levels of calcium, phosphorus, total alkaline phosphatase, FSH, LH, estradiol, intact-paratharmone and 25-hydroxy vitamin D in serum and urine levels of calcium, phosphorus and bone resorption marker calcium/creatinine(Ca/Cre) ratios were analyzed in all subjects. STATISTICAL ANALYSIS USED: One way ANOVA followed by Duncan's multiple range test. RESULTS: Significantly increased levels of FSH (P<0.001) and declined levels of urine calcium (P=0.015) and Ca/Cre ratios (P=0.006) were observed in >15 YSM group over 1-5 and 6-10 YSM groups. An inverse correlation was observed between serum FSH levels and urine Ca/Cre ratios (r = -0.655, P<0.001) in >15 YSM group. Comparable deficient estradiol levels were observed in all YSM groups. CONCLUSIONS: The risk of bone resorption is greater in early years than late years of menopause. The decreased bone resorption risk in late postmenopausal women might be due to increased FSH levels. However, further studies are required to explore this finding.

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Influence of the menopause and aging on spinal density in French women

Cited by 59 publications

References 14 publications

The effects of dietary-induced obesity on the biomechanical properties of femora in male rats

The effects of dietary-induced obesity on the biomechanical properties of femora in male rats

The impact of obesity on the musculoskeletal system

Influence of years since menopause on bone mineral metabolism in South Indian women

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