Influence of the menstrual cycle on glucose tolerance and insulin secretion

Bonora, Enzo; Zavaroni, Ivana; Alpi, O.; Pezzarossa, A.; Dall’Aglio, Elisabetta; Coscelli, C; Butturini, U

doi:10.1016/s0002-9378(87)80365-4

Cited by 33 publications

(24 citation statements)

References 11 publications

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“…Roy, Ghosh, and Bhattacharjee (4) and Jarett and Graver (5) performed OGTTs in nondiabetic women at different phases of the menstrual cycle and found the best glucose tolerance occurred early in the follicular phase. In contrast, Bonora et al (6) and Cudworth and Veevers (7), also using the OGTTs in healthy women, failed to identify such variation. Spellacy, Carlson, and Schade (8) used the intravenous glucose tolerance test in nondiabetic women and also failed to find variation associated with the menstrual cycle.…”

Section: Conclusion-mentioning

confidence: 92%

“…In healthy nondiabetic women, some investigators have reported a worsening in glucose tolerance, as assessed by the oral glucose tolerance test (OGTT), during the luteal phase (4,5). However, other studies that used the OGTT (6,7) or the intravenous glucose tolerance test (8) did not find significant changes in glucose tolerance or insulin concentration as a function of the menstrual cycle phase. Evaluation of insulin sensitivity by means of the euglycemic-hyperinsulinemic clamp technique has also failed to detect alterations during the luteal phase in nondiabetic women (9,10).…”

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confidence: 99%

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Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM

1992

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Section: Conclusion-mentioning

confidence: 92%

mentioning

confidence: 99%

Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM

1992

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“…The rate constant for glucose disappearance (K ITT ) was calculated using the formula 0.693/t 1/2 . The glucose t 1/2 was calculated from the slope of the least-square analysis of the plasma glucose concentration during the linear decay phase (20).…”

Section: Hormone and Biochemical Measurementsmentioning

confidence: 99%

Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway

Luciano

Carneiro

Carvalho

et al. 2002

European Journal of Endocrinology

115

101

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Background: Endurance training increases insulin-stimulated muscle glucose transport and leads to improved metabolic control in diabetic patients. Objective: To analyze the effects of endurance training on the early steps of insulin action in muscle of rats. Design: Male rats submitted to daily swimming for 6 weeks were compared with sedentary controls. At the end of the training period, anesthetized animals received an intravenous (i.v.) injection of insulin and had a fragment of their gastrocnemius muscle excised for the experiments. Methods: Associations between insulin receptor, insulin receptor substrates (IRS)-1 and -2 and phosphatidylinositol 3-kinase (PI3-kinase) were analyzed by immunoprecipitation and immunoblotting. Akt-1 serine phosphorylation and specific protein quantification were detected by immunoblotting of total extracts, and IRS-1/IRS-2-associated PI3-kinase activity were determined by thin-layer chromatography.Results: Insulin-induced phosphorylation of IRS-1 and IRS-2 increased respectively by 1.8-fold ðP , 0:05Þ and 1.5-fold ðP , 0:05Þ; whereas their association with PI3-kinase increased by 2.3-fold ðP , 0:05Þ and 1.9-fold ðP , 0:05Þ in trained rats as compared with sedentary controls, respectively. The activity of PI3-kinase associated with IRS-1 and IRS-2 increased by 1.8-fold ðP , 0:05Þ and 1.7-fold ðP , 0:05Þ respectively, in trained rats as compared with their untrained counterparts. Serine phosphorylation of Akt-1/PKB increased 1.7-fold ðP , 0:05Þ in trained rats in response to insulin. These findings were accompanied by increased responsiveness to insulin as demonstrated by a reduced area under the curve for insulin during an i.v. glucose tolerance test, by increased glucose disappearance rate during an insulin tolerance test, and by increased expression of glucose transporter-4. Conclusions: The increased responsiveness to insulin induced by chronic exercise in rat skeletal muscle may result, at least in part, from the modulation of the insulin signaling pathway at different molecular levels.

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“…Insulin resistance (ie, resistance to insulin-stimulated glucose uptake) is generally considered the primary defect underlying IRS and is a cardinal feature linking IRS with the development of atherosclerosis and CVD 11,20. Insulin resistance is a strong independent risk factor for CVD in both diabetic21 and nondiabetic individuals21–27 and has been causally linked to elevated blood pressure,13,28,30 dyslipidemia,13,31,32 inflammation,19,33 impaired fibrinolysis, 13,19 endothelial dysfunction,13,19,32,34 sympathetic activation, 13,29,34 and other indices of CVD risk 13,18,19. Insulin resistance increases dramatically with menopause,1,6,7,35,36 and is considered to be a key factor underlying the abrupt increase in CVD risk among women after menopause 6,36,37…”

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confidence: 99%

Menopause, the metabolic syndrome, and mind-body therapies

2008

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Cardiovascular disease risk rises sharply with menopause, likely due to the coincident increase in insulin resistance and related atherogenic changes that together comprise the metabolic or insulin resistance syndrome, a cluster of metabolic and hemodynamic abnormalities strongly implicated in the pathogenesis and progression of cardiovascular disease. A growing body of research suggests that traditional mind-body practices such as yoga, tai chi, and qigong may offer safe and cost-effective strategies for reducing insulin resistance syndrome-related risk factors for cardiovascular disease in older populations, including postmenopausal women. Current evidence suggests that these practices may reduce insulin resistance and related physiological risk factors for cardiovascular disease; improve mood, well-being, and sleep; decrease sympathetic activation; and enhance cardiovagal function. However, additional rigorous studies are needed to confirm existing findings and to examine long-term effects on cardiovascular health.

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Influence of the menstrual cycle on glucose tolerance and insulin secretion

Cited by 33 publications

References 11 publications

Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM

Alterations in Glucose Metabolism During Menstrual Cycle in Women With IDDM

Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway

Menopause, the metabolic syndrome, and mind-body therapies

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