Influence of the Morphology of Metal Nanoparticles Deposited on Surfaces of Silicon Oxide on the Optical Properties of SERS Substrates

Кукушкин, В. И.; Астраханцева, А. С.; Морозова, Е. Н.

doi:10.3103/s1062873821020155

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…There are many different types of SERS substrates [33][34][35][36] and schemes for creating aptasensors based on them [20,[37][38][39][40]. However, to create a quantitative method for the selective detection of SARS-CoV-2 from a group of other respiratory viral infections, this method should be the cheapest, simplest, and most reproducible.…”

Section: Discussionmentioning

confidence: 99%

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

et al. 2021

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During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.

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Section: Discussionmentioning

confidence: 99%

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

et al. 2021

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“…In metal nanoparticles whose sizes are comparable to the depth of penetration of the electromagnetic field of visible laser radiation (10–50 nm), the properties of surface plasmon polaritons depend strongly on the geometric sizes of the former [ 13 ]. It was shown that upon laser excitation with a wavelength of 532 nm, the best SERS nanostructures are surfaces in the shape of round metal granules with an ~50% coefficient of filling; at a wavelength of 785 nm, they are in the shape of prolate granules with coefficients of filling greater than 75% ( Tables 1 and 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to data obtained in [ 13 ], nominal thickness h of deposited silver was varied from 6 to 30 nm (6, 10, 15, 20, 25, and 30 nm) to optimize the island SERS films on Si/SiO 2 substrates (the layer of silicon oxide was 300 nm thick). The nominal thickness of gold was varied from 4.5 to 25 nm (4.5, 10, 15, 20, and 25 nm).…”

Section: Methodsmentioning

confidence: 99%

Formation of Island SERS Films on Surfaces of Track Membranes and Silicon Substrates

Serebrennikova

Кукушкин

Kristavchuk

et al. 2022

Bull. Russ. Acad. Sci. Phys.

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It is shown that metallic nano-island SERS-active layers can be created on the surfaces of porous track membranes made of polyethylene terephthalate and silicon substrates optimized for exciting laser radiation with wavelengths of 532 and 785 nm. Characteristic patterns of changes in the optical properties of SERS structures upon altering the morphology of metal nanoparticles on a substrate’s surface are established. Such structures can be used as SERS chips and highly sensitive filtering SERS elements in optical biosensors.

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“…At the same time, the replacement of NaCl by N(CH3)4Cl leads to the degradation of silver nanoislands, which can be attributed to the effect of chlorine ions. After exposure to PBS, the nanoisland films used as substrates for SERS provide a good signal from a monolayer of BPE, the surface enhancement factor being ~5⋅10 4 . This makes the out-diffused silver SERS substrates prospective for biological applications, including real-time measurements and biosensors.…”

Section: Discussionmentioning

confidence: 99%

“…Since the environment in the near field of a plasmon NPs can sufficiently change the SPR position, the analyte concentration and interactions of biomolecules can be detected in real time with a high resolution. SPR biosensors were effectively used for real-time biotin-streptavidin affinity measurements [1], detection of single non-absorbing molecules [2], measurements of protein-protein and protein-DNA interactions [3], and many others [4]. Surface enhanced Raman scattering (SERS), based on the enhancement of incident and scattered electric fields in the vicinity of NPs at the SPR excitation, helps to increase the sensitivity for detecting biological analytes at very low concentrations [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Stable in Biocompatible Buffers Silver Nanoisland Films for SERS

et al. 2021

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We investigated the stability of silver nanoisland films, which were formed on glass surface by the method of out-diffusion, in biocompatible buffers and the applicability of the films in surface enhanced Raman scattering (SERS). We have shown that silver nanoisland films are stable in one of the most widespread in biological studies buffer—phosphate buffer saline (PBS), and in 1:100 water-diluted PBS, in the PBS-based buffer, in which NaCl is replaced by the same amount of NaClO4, and in acidic phosphate buffer. At the same time, the replacement of NaCl in PBS by N(CH3)4Cl leads to the degradation of the nanoislands. It was shown that after exposure to PBS the nanoisland films provided a good SERS signal from a monolayer of 1,2-di(4-pyridyl)ethylene (BPE), which makes silver nanoisland films promising for biosensor applications. Additionally, in our experiments, we registered for the first time that silver nanoparticles formed in the bulk of the samples dissolved after exposing to PBS, while nanoislands on the glass surface stayed unchanged. We associate this phenomenon with the interaction of ions contained in PBS solution with silver, which results in the shift of corresponding chemical equilibrium.

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Influence of the Morphology of Metal Nanoparticles Deposited on Surfaces of Silicon Oxide on the Optical Properties of SERS Substrates

Cited by 8 publications

References 26 publications

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Formation of Island SERS Films on Surfaces of Track Membranes and Silicon Substrates

Stable in Biocompatible Buffers Silver Nanoisland Films for SERS

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