“…1 At the 1994 NIH (National Institutes of Health) Consensus Conference on the medical treatment of ulcer, the optimal treatment of ulcer was defined as combination therapy consisting of PPIs or histamine 2 -receptor blockers and broad-spectrum antibiotics; prescribing patterns have been changed in many communities, as a direct result, although there is still substantial room for improvement in some communities. 8 These discoveries have had a revolutionary effect on the previous concepts about acid secretion and ulcers. Previously, vagus nerve hyperactivity had been defined as a cause of increased acid secretion following the work of Dragstedt and others at the University of Chicago, Chicago, Ill, who demonstrated that patients with ulcers typically secreted acid continuously, as opposed to the "normal" triphasic pattern (cephalic, gastric, and intestinal phases) of secretion.…”