Influence of the Number of Alcohol and Water Bottles on Murine Alcohol Intake

Tordoff, Michael G.; Bachmanov, Alexander A.

doi:10.1097/01.alc.0000060529.30157.38

Cited by 21 publications

(15 citation statements)

References 19 publications

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“…Two-bottle preference assays with water and either 3% sucrose or 0.2% saccharin (Krishnan et al, 2007; Tordoff and Bachmanov, 2003) were performed using wild-type and Fgf21 -transgenic (Tg) mice expressing supraphysiological concentrations of FGF21 (Inagaki et al, 2007). Saccharin was included to eliminate the potentially confounding effect of caloric content.…”

Section: Resultsmentioning

confidence: 99%

“…Monkeys were provided standard lab diet 5K91 (LabDiet, St. Louis, MO) supplemented once a day with fruits and peanuts. The two-bottle saccharin preference assay was performed as described (Tordoff and Bachmanov, 2003). The monkeys underwent a training period during which the standard water system was shut off and 2 bottles, one with water and the other with water containing 0.2% saccharin, were attached side-by-side to the cage.…”

Section: Methodsmentioning

confidence: 99%

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FGF21 Regulates Sweet and Alcohol Preference

et al. 2016

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Summary Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice, and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

FGF21 Regulates Sweet and Alcohol Preference

et al. 2016

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“…The consumption of more alcohol and less water by CFA-treated males likely reflects increases in alcohol preference following repeated drug exposure. Although reductions in water intake is not characteristic for escalations in voluntary alcohol consumption (Griffin, 2014; Hwa et al, 2011; Tordoff and Bachmanov, 2008), it has been reported that mice treated with pro-inflammatory agents exhibit increased alcohol intake and reduced water intake when given access to CA2BC (Biesmans et al, 2013; Blednov et al, 2011; Stein et al, 1988). This is consistent with parallel studies showing that the impairment of pro-inflammatory cytokines reduces alcohol preference (Blednov et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Hwa

Makhijani

et al. 2019

Alcohol

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Sex differences in chronic pain and alcohol abuse are not well understood. The development of rodent models is imperative for investigating the underlying changes behind these pathological states. In the present study, we investigated whether hind paw treatment with the inflammatory agent Complete Freund’s Adjuvant (CFA) could generate hyperalgesia and alter alcohol consumption in male and female C57BL/6J mice. CFA treatment led to greater nociceptive sensitivity for both sexes in the Hargreaves test, and increased alcohol drinking for males in a continuous access two-bottle choice (CA2BC) paradigm. Regardless of treatment, female mice exhibited greater alcohol drinking than males. Following a 2-hour terminal drinking session, CFA treatment failed to produce changes in alcohol drinking, blood ethanol concentration (BEC), and plasma corticosterone (CORT) for both sexes. 2-hr alcohol consumption and CORT was higher in females than males, irrespective of CFA treatment. Taken together, these findings have established that male mice are more susceptible to escalations in alcohol drinking when undergoing pain, despite higher levels of total alcohol drinking and CORT in females. Furthermore, the exposure of CFA-treated C57BL/6J mice to the CA2BC drinking paradigm has proven to be a useful model for studying the relationship between chronic pain and alcohol abuse. Future applications of the CFA/CA2BC model should incorporate manipulations of stress signaling and other related biological systems to improve our mechanistic understanding of pain and alcohol interactions.

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“…Third, adolescents are particularly prone to drink alcohol to intoxication (Hopson, 2013; see Broadwater et al ., 2013), perhaps due to multiple differences in alcohol sensitivity compared to adults (Spear, 2014). Finally, the mere presence of multiple ethanol sippers in the home cage relative to water sippers can increase ethanol intake up to ≈20 g/kg/day in adult B6 mice (Tordoff and Bachmanov, 2003). Taken together, we hypothesize that the confluence of [i] sweetened ethanol (beginning at 3%) availability and [ii] social isolation [iii] during adolescence, along with [iv] two ethanol sippers, which constitutes four independent susceptibility factors, accounts for the high levels of voluntary consumption reported here.…”

Section: Discussionmentioning

confidence: 99%

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Panksepp

Rodriguez

Ryabinin

2016

Genes Brain and Behavior

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With its ease of availability during adolescence, sweetened ethanol (‘alcopops’) is consumed within many contexts. We asked here whether genetically based differences in social motivation are associated with how the adolescent social environment impacts voluntary ethanol intake. Mice with previously described differences in sociability (BALB/cJ, C57BL/6J, FVB/NJ and MSM/MsJ strains) were weaned into isolation or same-sex pairs (postnatal day 21), and then given continuous access to two fluids on postnatal days 34–45: One containing water and the other containing a ascending series of saccharin-sweetened ethanol (3-to-6-to-10%). Prior to the introduction of ethanol (postnatal days 30–33), increased water and food intake was detected in some of the isolation-reared groups, and controls indicated that isolated mice also consumed more ‘saccharin-only’ solution. Voluntary drinking of ‘ethanol-only’ was also higher in a subset of the isolated groups on postnatal days 46–49. However, sweetened ethanol intake was increased in all isolated strain-by-sex combinations irrespective of genotype. Surprisingly, blood ethanol concentration was not different between these isolate and socially housed groups 4 hours into the dark phase. Using lickometer-based measures of intake in FVB mice, we identified that a predominance of increased drinking during isolation transpired outside of the typical circadian consumption peak, occurring ≈8.5 hours into the dark phase, with an associated difference in blood ethanol concentration. These findings collectively indicate that isolate housing leads to increased consumption of rewarding substances in adolescent mice independently of their genotype, and that for ethanol this may be due to when individuals drink during the circadian cycle.

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Influence of the Number of Alcohol and Water Bottles on Murine Alcohol Intake

Abstract: Alcohol intake is strongly influenced by availability. The results point to a simple method of manipulating murine alcohol intake over a wide range. They provide an animal model that might be useful for understanding the influence of alcohol availability on human alcohol consumption.

Cited by 21 publications

References 19 publications

FGF21 Regulates Sweet and Alcohol Preference

FGF21 Regulates Sweet and Alcohol Preference

Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner for C57BL/6J mice

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

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