Influence of the replacement of the oxo function with the thioxo group on the antimycobacterial activity of 3-aryl-6,8-dichloro-2H-1,3-benzoxazine-2,4(3H)-diones and 3-arylquinazoline-2,4(1H,3H)-diones

Preparation, Characterization and First Application of Aerosil Silica Supported Acidic Ionic Liquid as a Reusable Heterogeneous Catalyst for the Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

“…[24][25][26] A small number of quinazolinones have been reported as potent chemotherapeutic agents in the treatment of tuberculosis. 27 In addition, quinazolinone moiety is a building block for approximately 150 naturally occurring alkaloids, such as glycosminine, 28 deoxyvasicinone, 29 and piriqualone. 30 Therefore, considerable efforts have been made to explore new simple and direct approaches towards the construction of 2,3-dihydroquinazolin-4(1H)-ones skeletons.…”

Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium

“…Quinazolines acquired much prominence among Ncontaining heterocyclic compounds because of their wide range of pharmacological and medicinal properties such as antibacterial [1], antidiabetic [2], antihypertensive [3], antitumor [4,5], anti-inflammatory [6], anticancer [7][8][9][10][11][12][13], antiviral [14,15] and antitubercular [16,17]. In addition, this ubiquitous structural motif is present in potent tyrosine kinase and cellular phosphorylation inhibitors [18][19][20], and also has found applications as ligand for benzodiazepine and neurotransmitter gamma-aminobutyric acid [GABA] receptors in the central nervous system [CNS] [21,22] and as DNA binders [23].…”

Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

“…Specifically, quinazolines and their derivatives represent a medicinally and pharmaceutically important class of heterocyclic motifs that are found as the core structural skeletons in a variety of drug molecules such as prazosin [2] and lapatinib [3] (Figure 1). They possess a wide range of biological and pharmacological activities, including anticancer [4], antiviral [5], antitubercular [6] and antimalarial properties [7]. Zhang et al [8] have reported quinazoline synthesis with 2-aminobenzophenones and benzylic amines via SP 3 C-H activation, where I 2 served as a catalyst in the presence of an added oxidant at a relatively high temperature (90 °C) and relatively longer reaction time (12 h).…”