Influence of the Skin Temperature on the Axon Reflex Pilomotion Produced by Nicotine in Human Skin

Sakurai, Minoru

doi:10.1620/tjem.128.1

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Dermal Reactivity To Nicotine1

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1992

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Cited by 3 publications

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“…The results of temperature investigations [19,20] indicate that the effects of nicotine may be enhanced at higher ambient or skin temperature, possibly facilitated by normal thermophysiological reactivity. Smaller doses of nicotine were required to induce sweating in 'warm' skin, and induce piloerection at lower temperatures.…”

Section: Dermal Reactivity To Nicotinementioning

confidence: 99%

The Local Side Effects of Transdermally Absorbed Nicotine

Smith

Smith²,

Maibach³

et al. 1992

Skin Pharmacol Physiol

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Percutaneous nicotine administration induces predominant sudorific and rubiform responses in the skin which may be accompanied by subtle piloerection, hyperalgesia and pruritus (although these signs are not overtly manifest). These dermal responses are complex and mechanisms have been proposed for the direct nicotine-stimulation of sweat glands, piloerection and vasoconstriction. These reactions are accompanied by secondary activation and release of vasodilator peptides which produce a predominating vasodilator tone following topical administration, this response masking the direct axon reflex-mediated vasoconstriction.

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Section: Dermal Reactivity To Nicotinementioning

confidence: 99%