2021
DOI: 10.3892/br.2021.1477
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Influence of the SOD2 A16V gene polymorphism on alterations of redox markers and erythrocyte membrane fatty acid profiles in patients with multiple chemical sensitivity

Abstract: Chronically increased oxidative stress has been reported in patients with multiple chemical sensitivity (MCS). Recently, a single nucleotide polymorphism of the gene coding for mitochondrial superoxide dismutase (SOD2), namely the missense substitution A16V (C47>T) resulting in alteration of SOD2 enzyme activity, has been reported to be associated with MCS. However, the influence of SOD2 A16V genetic background on redox status of patients with MCS has not yet been investigated. Here, the results of a retrospec… Show more

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Cited by 5 publications
(1 citation statement)
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“…Targeted genetic association studies have focused on (a) inflammatory and oxidative stress pathways [23]; (b) genes coding for enzymes that metabolize xenobiotics (e.g., SOD, NAT) [24][25][26]; (c) genetic polymorphisms that involve xenobiotic detoxification processes such as phase I and II enzymes [27,28]; (d) cytochrome P450 isoenzymes involved in metabolizing drugs [29]; and (e) genes such as PON1/PON2 involved in the detoxification of organophosphate pesticides [26,30]. However, reports from other researchers have been inconsistent [23,31,32].…”
Section: Biological Correlates Of CImentioning
confidence: 99%
“…Targeted genetic association studies have focused on (a) inflammatory and oxidative stress pathways [23]; (b) genes coding for enzymes that metabolize xenobiotics (e.g., SOD, NAT) [24][25][26]; (c) genetic polymorphisms that involve xenobiotic detoxification processes such as phase I and II enzymes [27,28]; (d) cytochrome P450 isoenzymes involved in metabolizing drugs [29]; and (e) genes such as PON1/PON2 involved in the detoxification of organophosphate pesticides [26,30]. However, reports from other researchers have been inconsistent [23,31,32].…”
Section: Biological Correlates Of CImentioning
confidence: 99%