Influence of the Spray Method on Product Quality and Morphology in Spray Drying

Walzel, Peter

doi:10.1002/ceat.201100051

Cited by 45 publications

(14 citation statements)

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“…The reduction of the particle size at different solid concentrations due to release of the water volume along the drying process is, then, only insignificantly different. [18] Assuming a porosity of the dried particles e ¼ 0.5, droplet sizes in the range of 130-155 mm are needed, leading to particles in the desired size range. The desired droplet size can be achieved at wheel speeds of 6,300 rpm and above (Fig.…”

Section: Results and Discussion Droplet Size Analysismentioning

confidence: 99%

Spray Drying of Mannitol as a Drug Carrier—The Impact of Process Parameters on Product Properties

et al. 2012

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Powders intended for the use in dry powder inhalers have to fulfill specific product properties, which must be closely controlled in order to ensure reproducible and efficient dosing. Spray drying is an ideal technique for the preparation of such powders for several reasons. The aim of this work was to investigate the influence of spray-drying process parameters on relevant product properties, namely, surface topography, size, breaking strength, and polymorphism of mannitol carrier particles intended for the use in dry powder inhalers. In order to address this question, a full-factorial design with four factors at two levels was used. The four factors were feed concentration (10 and 20% [w/w]), gas heater temperature (170 and 190 C), feed rate (10 and 20 L/h), and atomizer rotation speed (6,300 and 8,100 rpm). The liquid spray was carefully analyzed to better understand the dependence of the particle size of the final product on the former droplet size. High gas heater temperatures and low feed rates, corresponding to high outlet temperatures of the dryer (96-98 C), led to smoother particles with surfaces consisting of smaller crystals compared to those achieved at low outlet temperatures (74-75 C), due to lower gas heater temperatures and higher feed rates. A high solution concentration of the feed also resulted in the formation of comparably rougher surfaces than a low feed concentration. Spray-dried particles showed a volumeweighted mean particle size of 71.4-90.0 lm and narrow particle size distributions. The mean particle size was influenced by the atomizer rotation speed and feed concentration. Higher rotation speeds and lower feed concentrations resulted in smaller particles. Breaking strength of the dried particles was significantly influenced by gas heater temperature and feed rate. High gas heater temperatures increased the breaking strength, whereas high feed rates decreased it. No influence of the process parameters on the polymorphism was observed. All products were crystalline, consisting of at least 96.9% of mannitol crystal modification I.

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Section: Results and Discussion Droplet Size Analysismentioning

confidence: 99%

Spray Drying of Mannitol as a Drug Carrier—The Impact of Process Parameters on Product Properties

et al. 2012

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“…However, recent trends and demands for specially engineered particles of a particular size and size distribution and atomization of highly viscous fluids, which are otherwise difficult to atomize using conventional techniques, has resulted in the development of novel atomization techniques, such as ultrasonic atomizers and multiple fluid channel atomizers. Walzel (2011) has reviewed various spraying methods and their effect on the quality and morphology of the spray-dried product.…”

Section: Spray Dryingmentioning

confidence: 99%

Recent Developments in Drying Technologies for Foods

Jangam

Mujumdar

2013

Food Engineering Series

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“…Selection of a proper atomizer is very important which decides the particles properties in addition to other operating parameters. For more details readers can refer to the recent review [25][26][27] . Spray drying for encapsulation and microencapsulation of valuable foods and neutraceutical ingredients is a one step and highly cost-effective technique compared to other methods of encapsulation.…”

Section: Spray Dr Ying (Sd)mentioning

confidence: 99%