The aim of this paper was to evaluate the status and trends of water quality in a stressed coastal lagoon in Cartagena, Colombian Caribbean. The water quality data over an eight-year period was analyzed. The study was focused on water parameters as dissolved oxygen (DO), biochemical oxygen demand (BOD5), chemical oxygen demand (COD), salinity, pH, total dissolved solids, total coliforms (TC), ammonium (NH4 +) and total phosphorus (TP). The analysis was conducted in line with Colombian national water standard. Results showed that BOD5, COD and phosphorus are out of the limits for this variables in Colombia. Principal components analysis detected four components that explain 70 % of the variance of data and showed that anthropogenic and temporal factors might be affecting the variation. 1340 Ildefonso Baldiris-Navarro et al.