2012
DOI: 10.1016/j.phymed.2012.05.008
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Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis

Abstract: In this study we examined the acute in vivo effect and short- and long-term in vitro effects of samples from native and commercial Ilex paraguariensis on glucose homeostasis. Also, the potential effect of I. paraguariensis on serum insulin secretion was investigated. The chemical identification and quantification of methyl xanthines and polyphenols in CH₂Cl₂, EtOAc and n-BuOH fractions of native I. paraguariensis as well as infusions of green and roasted I. paraguariensis from a commercial source was verified … Show more

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Cited by 42 publications
(32 citation statements)
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“…Although HE 500 more significantly lowered rats serum glucose levels, it did not significantly inhibit maltase activity. This finding is in agreement with Pereira et al (2011Pereira et al ( , 2012, who found that higher doses of extracts and substances, did not affect disacharidase activity. These findings reinforce the idea that HE affects serum glucose by increasing glucose storage (as glycogen) in the liver and muscle.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Although HE 500 more significantly lowered rats serum glucose levels, it did not significantly inhibit maltase activity. This finding is in agreement with Pereira et al (2011Pereira et al ( , 2012, who found that higher doses of extracts and substances, did not affect disacharidase activity. These findings reinforce the idea that HE affects serum glucose by increasing glucose storage (as glycogen) in the liver and muscle.…”
Section: Discussionsupporting
confidence: 93%
“…All drugs were diluted with saline (0.9%) in established doses and administered orally by gavage in a volume of 0.5 ml/100 g body weight (Trovato et al, 1996;Diehl et al, 2001). Glucose levels were measured before the rats received the treatment (zero time) and 30 min after glucose was administrated (4 g/kg) (Alam et al, 2011;Pereira et al, 2012). Blood samples were collected from the tail vein just prior to and 30, 60 and 180 min after glucose loading, and the glucose level (mg/dl) was assayed by a glucometer (Accu-Chek ® Performa).…”
Section: Oral Glucose Tolerance Curvementioning
confidence: 99%
“…When comparing the results obtained with phenolics, flavonoids, tannins and alkaloids contents assays, we may observe a relation between dosages for fractions. Pereira et al 18 working with Ilex paraguariensis found phenolics contents ranging from 277.10 to 96.82 mg/g, in our study we found higher values. Considering total phenolic contents, the results obtained for T. catharinensis in our study were very close to those obtained by Janovik et al 6 14 In this study, T. catharinensis leaves exhibited very good antioxidant capacity ( Fig.…”
Section: Resultscontrasting
confidence: 48%
“…The effects of I. paraguariensis on glucose metabolism have also been studied in in vivo experiments in animals and humans. I. paraguariensis have proven to have an antihyperglycemic potential role in a study, in which I. paraguariensis was able to improve significantly the oral glucose tolerance curve; furthermore, I. paraguariensis inhibited in vitro disaccharidases activities and reduced the formation of advanced glycation end‐products in a characteristic long‐term effect (Pereira et al, ). The reduction of fat weight, plasma triglyceride level, and both liver and fat tissues glucose oxidation was observed in healthy rats fed with a standard diet (Resende et al, ).…”
Section: Resultsmentioning
confidence: 99%