Influence of the wettability of different titanium surface topographies on initial cellular behavior

Nishimura, Tomoko; Ogino, Yoichiro; Ayukawa, Yasunori; Koyano, Kiyoshi

doi:10.4012/dmj.2017-334

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…The contact angle determines the wettability of materials. In general, a hydrophilic surface results in a better osteogenic ability than a hydrophobic surface [ 22 ]. In the present study, the average contact angle of SLA-titanium was 101.8°, which indicates that SLA-titanium can be considered hydrophobic.…”

Section: Discussionmentioning

confidence: 99%

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Osteoblast Response of Additively Manufactured Zirconia and Alumina-Toughened Zirconia

et al. 2022

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Zirconia ceramics have been widely used in dentistry. Herein, we assess the surface morphology, surface texture, and osteoblast response of additively manufactured zirconia and alumina-toughened zirconia (ATZ) in comparison with titanium. The surface roughness, contact angle, and surface microstructure of titanium sandblasted with large-grit alumina and subsequently acid-etched using 18% HCl and 49% H2SO4 (SLA-titanium), uniaxially pressed zirconia (UP zirconia), additively manufactured zirconia (AM zirconia), and additively manufactured ATZ (AM ATZ) were investigated. Moreover, the cell viability, alkaline phosphatase (ALP) activity, and gene expression of type I collagen on these materials were evaluated. The data were statistically analyzed using one-way ANOVA with Tukey’s post hoc test. SLA-titanium showed the highest surface roughness and contact angle. The other three materials showed comparable surface roughness and contact angles. Micro- and nanoroughness were observed on the surface of SLA-titanium. UP zirconia and AM zirconia had similar surface morphologies. The cell viability, ALP activity, and gene expression of type I collagen on AM zirconia were comparable to or better than those on SLA-titanium. Our results indicate that AM zirconia is a promising material for zirconia dental implants.

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Section: Discussionmentioning

confidence: 99%

“…The ALP activity at 7 days was negatively correlated with the surface roughness (S a , R a ) and contact angle. Nishimura et al reported that a hydrophilic surface was more advantageous to initial cell attachment than a hydrophobic surface [ 22 ]. It is therefore reasonable that SLA-titanium showed lower ALP activity at 7 days.…”

Section: Discussionmentioning

confidence: 99%

Osteoblast Response of Additively Manufactured Zirconia and Alumina-Toughened Zirconia

et al. 2022

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“…A pure titanium surface will form an oxidized layer immediately following exposure to air, which is quite stable [21]. It has been shown that multiple types of cells can proliferate and adhere to pure titanium [22,23,24,25]. Therefore, pure titanium, with its excellent biocompatibility and corrosion resistance, has been widely used as a biocompatible material for more than half a century [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydrothermal Treatment with Distilled Water on Titanium Alloy for Epithelial Cellular Attachment

et al. 2019

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The enhancement of oral epithelial adhesion to the trans-mucosal material of dental implants may improve their long-term stability. The aim of this study is to investigate whether hydrothermal treatment with distilled water (HT-DW) applied to a Ti-6Al-4V (Ti64) alloy could improve epithelial cellular attachment. We hypothesized that this treatment would enhance the adsorption of proteins and the adhesion of gingival epithelial GE1 cells. This treatment changed the surface crystal structure into an anatase type of titanium oxide without an apparent change of surface roughness or topography. Nitrogen was not detected on the HT-DW-treated Ti64, which indicates decontamination. HT-DW-treated Ti64 exhibited a hydrophilic surface with a less than 10° angle of water contact. Adsorption of laminin-332 to the HT-DW-treated Ti64 was significantly greater than that of the untreated Ti64 plates (64). The number of GE1 cells on the HT-DW-treated Ti64 at 1 and 3 days was significantly lower than that on 64; however, cell adhesion strength on HT-DW was greater, with a higher expression of integrin β4, compared with 64. This indicates that the HT-DW treatment of Ti64 improves the integration of GE1 cells, which might facilitate the development of a soft tissue barrier around the implant.

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Section: Discussionmentioning

confidence: 99%

“…Osteoblasts interact with the substrates via integrins, which cluster and associate with cytoskeletal elements forming focal adhesions, and the rough and hydrophilic surface of the biomaterials could augment the density of focal adhesions. 36 As a result of the extracellular cues, the more numerous focal adhesions present on the substrates increase cell complexity and enable the formation of filopodia-like structures, through the cytoskeleton arrangement. 37 In this study, the cells adhesion and spreading on the samples were improved with the increase of SN content in the microporous coatings, demonstrating that SN played important roles in promoting cell adhesion and spreading.…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 99%

Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

Yang

Qian

et al. 2019

ACS Biomater. Sci. Eng.

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To improve the antibacterial and osteogenic activities of poly(etherketoneketone) (PEKK), concentrated sulfuric acid (H2SO4) suspension with silicon nitride (SN) microparticle was utilized to modify PEKK surface. Through sulfonation reaction, microporous coatings of PEKK/SN composites were created on PEKK surface, which were integrated with PEKK substrate. The results showed that the content of SN in the microporous coatings increased with the increase of SN content in H2SO4 suspension (PKS without SN, PKSC5 and PKSC10 with 5 and 10 wt % SN content in H2SO4) and that the surface roughness and hydrophilicity of microporous coatings on PEKK were significantly improved with the SN content increasing. In addition, the microporous coating of PKSC10 with high SN content exhibited excellent antibacterial activity due to the synergistic action of the presence of amino (−NH2) and sulfonic acid (−SO3H) groups as well as the improvement of protein absorption. Moreover, the microporous coating of PKSC10 obviously stimulated adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, histological and push-out load evaluation indicated that the microporous coating of PKSC10 significantly promoted osteogenesis and osseointegration in vivo. The results suggested that the microporous coating of PKSC10 with high SN content display good biocompatibility, antibacterial and osteogenic activities, and osseointegration ability, which would have great potential for bone substitutes.

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Influence of the wettability of different titanium surface topographies on initial cellular behavior

Cited by 11 publications

References 25 publications

Osteoblast Response of Additively Manufactured Zirconia and Alumina-Toughened Zirconia

Osteoblast Response of Additively Manufactured Zirconia and Alumina-Toughened Zirconia

Effect of Hydrothermal Treatment with Distilled Water on Titanium Alloy for Epithelial Cellular Attachment

Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

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