The use of passive safety systems are more and more diffused in many technological fields. Natural circulation is probably one of the main phenomenon applied in this kind of systems: indeed, as known, by means of gravity and buoyancy forces, the fluids can circulate without any external power sources. In this paper, a preliminary analysis (also by comparisons between experimental tests and numerical simulations) of a natural circulation based loop (namely a natural circulation based facility installed at University of Genova) is presented. Starting from some experimental results, the data deriving from CFD loop simulations (both in steady and in unsteady conditions) are used for a first preliminary validation, mainly in order to have a computational tool reliable and able to computationally simulate motion inversions related phenomena. The physical inversions phenomena are very well reproduced also by the a simplified numerical 2D model of the loop, and the physical considerations related to the temperature and velocity fluctuations during the transient simulations, are in agreement with the well-known observations formulated by Welander on the basis of a simple point source analysis scheme.