Influence of three synthetic membranes on the release of caffeine from concentrated W/O emulsions

Clément, Pascale; Laugel, Cécile; Marty, Jean‐Paul

doi:10.1016/s0168-3659(99)00276-x

Cited by 36 publications

(16 citation statements)

References 13 publications

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“…It was statistically observed that both membranes impacted the marker release differently (p < 0.05). This study is consistent with previous works of Clement et al (25) who described the release of caffeine from water-inoil emulsions and alcoholic gels. Here the nature of the membrane also affected the release.…”

Section: Discussionsupporting

confidence: 94%

In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes

Khiljee¹,

Rehman²,

Sarfaz³

et al. 2010

Dissolution Technol.

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Herbal remedies like the Indian penny wort, walnut, and turmeric are useful in traditional medicine for the treatment of many skin diseases, especially eczema. The aim of the present study was to formulate a microemulsion, a gel, and an ointment containing these plant extracts and to evaluate their in vitro release using markers. The in vitro release was assessed using Franz cells and two different types of membranes, nylon and cellulose. The three formulations showed different releases, except for the microemulsion and gel of Indian penny wort and walnut, which had similar release profiles. The study showed that the nylon membrane had a faster release than the cellulose membrane. However, first-order release kinetics for all three formulations were only observed for the cellulose membrane. In this study, the cellulose membrane showed more discriminative power to differentiate among the three tested herbs and their formulations. This demonstrates that it is important to investigate the impact of the membrane on the release pattern of different formulations. In vitro diffusion cell experiments can be used to develop improved formulations of traditional medicines.

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Section: Discussionsupporting

confidence: 94%

In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes

Khiljee¹,

Rehman²,

Sarfaz³

et al. 2010

Dissolution Technol.

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“…According to a recent study,[15] the polysulfone membrane is not a limiting factor for the release of caffeine and enables the study of the in vitro release in this molecule.…”

Section: Resultsmentioning

confidence: 99%

Influence of drug concentration on the diffusion parameters of caffeine

et al. 2011

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Background and Objectives:In the fields of the pharmaceutical and cosmetic industries and in toxicology, the study of the skin penetration of molecules is very interesting. Various studies have considered the impact of different physicochemical drug characteristics, skin thickness, and formulations, on the transition from the surface of the skin to the underlying tissues or to the systemic circulation; however, the influence of drug concentration on the permeation flux of molecules has rarely been raised. Our study aims to discover the influence of caffeine concentration in a formulation on the percutaneous penetration from gels, as a result of different dose applications to polysulfate membrane and human skin.Materials and Methods:For this purpose, three identical base gels were used at 1, 3, and 5% of caffeine, to evaluate the effect of the concentration of caffeine on in vitro release through the synthetic membrane and ex vivo permeation through the human skin, using diffusion FranzTM cells.Results:The diffusion through the epidermal tissue was significantly slower than through the synthetic membrane, which recorded an increase of flux with an increase in the concentration of caffeine. The skin permeation study showed that diffusion depended not only on the concentration, but also on the deposited amount of gel. Nevertheless, for the same amount of caffeine applied, the flux was more significant from the less concentrated gel.Conclusion:Among all the different concentrations of caffeine examined, 1% gel of caffeine applied at 5 mg / cm2 showed the highest absorption characteristics across human skin.

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“…The drug/active has to diffuse across shorter distances to reach the surface owing to the increased surface area: mass ratio drug transport from the internal to the continuous phase is enhanced (Washington and Evans, 1995). However, the volume fraction of the dispersed phase and internal phases and the surfactant interfacial film ratio should also be considered (Clément et al, 2000). Moreover, when polymeric surfactants are used, a decrease in the internal phase:interfacial film volume ratio indicates the formation of a thickener surfactant film, which suggests superior stability and a potential barrier to drug transport.…”

Section: Discussionmentioning

confidence: 99%