Influence of thyroid hormone status on mevalonate metabolism in rats.

Kr, Feingold; Wiley, Millie Hughes; MacRae, Gordon; Siperstein, Marvin D.

doi:10.1172/jci109900

Cited by 15 publications

(4 citation statements)

References 15 publications

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“…As to Choi homeostasis, hypothyroidism is associated with hypercholesterolemia [8,10] due to decreased de gradation of C'hol in spite of a decrease in de novo Choi synthesis [6,9,20], Thyroid hormones stimulate cholesterogenesis by increasing the conversion of acetate to mevalonate [27] and influence mevalonate metabolism in rats with intact kidneys [5], The kidneys have been re ported to be the main site of circulating mevalonate metabolism [28][29][30]. It is held that in rats with intact kidneys hypothyroidism reduces the renal conversion of circulating mevalonate to Choi without an effect of this conversion in the liver or carcass [5].…”

Section: Discussionmentioning

confidence: 99%

“…It is held that in rats with intact kidneys hypothyroidism reduces the renal conversion of circulating mevalonate to Choi without an effect of this conversion in the liver or carcass [5]. Thus, it was not surprising to observe no effect of chronic T3 supplemen tation on Choi in uremic rats.…”

Section: Discussionmentioning

confidence: 99%

“…In the rat, the hypothyroid state per se is known to be accompanied by disturbances of lipoprotein metabolism, essentially by hypercholesterolemia, a disturbed metabo lism of mevalonate, and also hypotriglyceridemia due to an increase in lipoprotein lipase (LPL) activity [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Chronic Triiodothyronine Supplementation Does Not Improve the Lipoprotein Disorders of Mildly Uremic Rats

Lacour

Roullet²,

Ricordel

et al. 1987

Nephron

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The present study was performed to appreciate the potential role that thyroid deficiency could play in the energy homeostasis and lipid metabolism of experimental chronic renal failure. For this purpose, 12 uremic rats that were supplemented with T₃ (0.4 μg/100 g body weight/day) during 5 weeks by means of osmotically driven minipumps were compared to 12 unsupplemented uremic rats and 12 control rats. The chronic supplementation of uremic rats with T₃ induced no significant change in body weight gain or in the serum concentration of insulin, glucose, glycerol, nonesterified fatty acids, total triglycerides (TG), total cholesterol, and total choline phospholipids. Similarly, the metabolism of TG-rich lipoproteins was not affected by the supplementation with T₃ in these uremic rats as appreciated by TG production or TG degradation (adipose tissue lipoprotein lipase activity). T₃ administration induced a significant decrease in serum β-hydroxybutyrate concentration and an increase in serum lactate concentration. Furthermore, heparin-releasable hepatic TG lipase activity as expressed per total liver mass was decreased in uremic rats treated with T₃. The latter changes were observed in the absence of modifications of serum glucose or TG concentration. We conclude from these observations that rats with a moderate degree of chronic uremia do not seem to have a cellular thyroid deficiency sufficient to disturb their energy or lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Triiodothyronine Supplementation Does Not Improve the Lipoprotein Disorders of Mildly Uremic Rats

Lacour

Roullet²,

Ricordel

et al. 1987

Nephron

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“…The regulation of circulating MVA by sterol and shunt pathways is a complex interplay of dietary [15,16], sex hormones [17][18][19][20], thyroid hormone [21], and insulin [22]. The relationship between plasma MVA and a number of other key metabolic and physiological processes provides indirect evidence for the importance of the MVA pathway and its association with plasma MVA levels.…”

Section: Plasma Mva Metabolismmentioning

confidence: 99%

Plasma mevalonate and its importance in nephrology

1994

Nephrology Dialysis Transplantation

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Thyroid hormone action on intermediary metabolism

Müller

Seitz

1984

Klin Wochenschr

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Despite their enhanced endogenous de novo cholesterol synthesis, hyperthyroid patients exhibit decreased total and low-density lipoprotein (LDL) cholesterol levels in the serum because of a concomitant increase in LDL catabolism, cholesterol excretion by bile and a reduced enterohepatic bile acid circulation. Hypothyroidism exhibits a reduction (1) in the synthesis of cholesterol and (2) in LDL catabolism, whereas cholesterol reabsorption is unchanged or even enhanced. In addition, obese hypothyroid patients showed an increased cholesterol synthesis which is independent of thyroid hormones and which contributes to the observed LDL cholesterolaemia. Thyroid hormones per se have only a minor influence on plasma triglyceride (TG) levels, but they induce an acceleration of TG turnover and chylomicron clearance rate. In addition, the hepatic lipogenic capacity is increased in hyperthyroidism and reduced in hypothyroidism. However, hepatic total and very low-density lipoprotein (VLDL) triglyceride output is decreased by thyroid hormones due to a reduced re-esterification and a simultaneously increased oxidation of newly synthesized fatty acids. Hypothyroid livers, by contrast, reveal an increased VLDL secretion. Despite their reduced lipogenesis, obese hypothyroidism is often accompanied by a hypertriglyceridaemia type III. The simultaneous stimulation of the synthesis of fatty acids, which are still in part converted to TG, and the degradation of TG contributes to the enhanced thermogenesis in hyperthyroid patients. The concentration and turnover of free fatty acids (FFA) are increased in hyperthyroidism, resulting from a thyroid hormone-induced increase in: (1) lipolysis, explained by an increased adipose tissue sensitivity for lipolytic hormones; and (2) oxidation of fatty acids to CO2 as well as to ketone bodies (KB).(ABSTRACT TRUNCATED AT 250 WORDS)

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Influence of thyroid hormone status on mevalonate metabolism in rats.

Abstract: A B S T R A C T

Cited by 15 publications

References 15 publications

Chronic Triiodothyronine Supplementation Does Not Improve the Lipoprotein Disorders of Mildly Uremic Rats

Chronic Triiodothyronine Supplementation Does Not Improve the Lipoprotein Disorders of Mildly Uremic Rats

Plasma mevalonate and its importance in nephrology

Thyroid hormone action on intermediary metabolism

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