Influence of thyroid hormone treatment on the respiratory activity of cerebral mitochondria from hypothyroid rats. A critical re-assessment

Katyare, Surendra S.; Rajan, Rehim N.

doi:10.1016/j.expneurol.2005.06.004

Cited by 28 publications

(30 citation statements)

References 19 publications

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“…The content of cytochrome oxidase in mitochondria from various tissues including brain is significantly influenced by hormonal status of the organism. [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 98%

Diabetic Modulation of the Temperature Kinetics Properties of Cytochrome Oxidase Activity in Rat Brain Mitochondria

2007

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The effects of alloxan-diabetes and subsequent treatment with insulin on temperature kinetics properties of cytochrome oxidase activity from rat brain mitochondria were examined. The enzyme activity decreased only at the late stage of diabetes which was not normalized by insulin treatment; however at early stage of diabetes hyper-stimulation occurred. In the control animals the Arrhenius plot was chair shaped with three energies of (E1, E2 and E3) and two phase transition temperatures (Tt1 and Tt2). At early diabetic stage the Arrhenius plot became biphasic and E1)and E2 decreased; insulin treatment reversed chair-shaped pattern with increase in E2. These changes correlated with transient changes in the phospholipids profiles especially decreased acidic phospholipids. The temperature kinetics parameters were minimally affected at the late stage of diabetes or by insulin treatment. Thus at the late stage the brain tissue seems to have readjusted to its insulin homeostasis.

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“…The content of cytochrome oxidase in mitochondria from various tissues including brain is significantly influenced by hormonal status of the organism. [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 98%

Diabetic Modulation of the Temperature Kinetics Properties of Cytochrome Oxidase Activity in Rat Brain Mitochondria

2007

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“…One group which did not receive any treatment served as the thyroidectomized control and is designated as T x . The second group of animals received subcutaneously (s.c.) 25 μg T 3 / 100 g body weight two days prior to sacrifice (10). This group is referred to as T 3 .…”

Section: Methodsmentioning

confidence: 99%

“…Animals : Weanling (3 week old, 30-35 g body weight) male rats belonging to Charles-Foster strain were surgically thyroidectomized as described in details elsewhere (10). The animals were allowed to grow for 8-10 weeks.…”

Section: Methodsmentioning

confidence: 99%

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Thyroidal regulation of substrate kinetics properties of cytochrome oxidase in rat liver mitochondria

Modi

Katyare

Patel

2008

Indian J Clin Biochem

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“…It was found that the administration of thyroid hormones causes upregulation of several genes, including the genes participating in circadian regulation and in regulation of signaling pathways (Diez et al 2008). Nongenomic action of thyroid hormones includes modulation of neuronal excitability (Caria et al 2009) and oxidative energy metabolism (Katyare and Rajan 2005), prevention against NMDA-receptors dependent neuronal damage (Alva-Sánchez et al 2009), and regulation of synaptosomal protein phosphorylation (Sarkar 2008). An overall decline in the metabolic activity of the hypothyroid brain compared with euthyroid brain was observed, characteristically manifested in energy metabolism, osmolytic/antioxidant capacity, and protein/lipid synthesis (Constantinou et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism

et al. 2012

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Hypothyroidism in humans provokes various neuropsychiatric disorders, movement, and cognitive abnormalities that may greatly depend on the mitochondrial energy metabolism. Brain cells contain at least two major populations of mitochondria that include the non-synaptic mitochondria, which originate from neuronal and glial cell bodies (CM), and the synaptic (SM) mitochondria, which primarily originate from the nerve terminals. Several parameters of oxidative stress and other parameters in SM and CM fractions of hippocampus of adult rats were compared among euthyroid (control), hypothyroid (methimazol-treated), and thyroxine (T4)-treated hypothyroid states. nNOS translocation to CM was observed with concomitant increase of mtNOS's activity in hypothyroid rats. In parallel, oxidation of cytochrome c oxidase and production of peroxides with substrates of complex I (glutamate + malate) were enhanced in CM, whereas the activity of aconitase and mitochondrial membrane potential (ΔΨm) were decreased. Furthermore, the elevation of mitochondrial hexokinase activity in CM was also found. No differences in these parameters between control and hypothyroid animals were observed in SM. However, in contrast to CM, hypothyroidism increases the level of pro-apoptotic K-Ras and Bad in SM. Our results suggest that hypothyroidism induces moderate and reversible oxidative/nitrosative stress in hippocampal CM, leading to the compensatory elevation of hexokinase activity and aerobic glycolysis. Such adaptive activation in glycolytic metabolism does not occur in SM, suggesting that synaptic mitochondria differ in their sensitivity to the energetic disturbance in hypothyroid conditions.

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Influence of thyroid hormone treatment on the respiratory activity of cerebral mitochondria from hypothyroid rats. A critical re-assessment

Cited by 28 publications

References 19 publications

Diabetic Modulation of the Temperature Kinetics Properties of Cytochrome Oxidase Activity in Rat Brain Mitochondria

Diabetic Modulation of the Temperature Kinetics Properties of Cytochrome Oxidase Activity in Rat Brain Mitochondria

Thyroidal regulation of substrate kinetics properties of cytochrome oxidase in rat liver mitochondria

Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism

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