Influence of Tinospora cordifolia on wound healing in wistar rats

Hashilkar, Nayana K.; Patil, P. A.; Bagi, Jayasheela G; Patil, Sunita Y; Angadi, Netravathi Basavaraj

doi:10.18203/2319-2003.ijbcp20161546

Cited by 12 publications

(17 citation statements)

References 17 publications

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“…Based on the search done with the aforementioned methodology, eight papers reported on the wound healing properties of T. cordifolia (table 2). Studies have been done on topical treatment [8][9][10][11] with doses ranging from 1% to 10%, in either cream or ointment bases, as well as oral treatment [12][13][14][15] with doses ranging from 200 mg/kg to 600 mg/kg. However, the wound healing ability of the combination of topical insulin and TC extract was more significant than the extract alone.…”

Section: Tinospora Cordifoliamentioning

confidence: 99%

“…Almost every study used the excision and incision wound model [8,9,[11][12][13][14]. Only two studies were done on the dead space wound model [12,13], one on the burn wound model [10] and one on the diabetic wound model [15].…”

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

“…Based on the parameters observed, the use of T. cordifolia is found to hasten wound healing [8,11,12,14,15]; early re-epithelisation which is associated with increased keratinocyte proliferation and migration to wound surface [8], increased tensile strength [8,[11][12][13].…”

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

“…T. cordifolia-treated groups also exhibited an increased amount of granulation tissue which indicates higher protein content [13,14] and increased collagen content which is indicated by the increased amount of hydroxyproline [12,13].…”

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

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The Potential Role of Genus Tinospora in Wound Healing: A Review

Fernandez¹,

Shivashekaregowda²,

Yow³

2021

Int J Pharm Pharm Sci

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Genus Tinospora has been used in traditional medicine throughout various parts of Asia, particularly in India, China, Thailand, Malaysia and Cambodia. Its ethnomedicinal uses include treatment for fever, cold, oral ulcer, headaches, diarrhoea, diabetes, digestive disorder and rheumatoid arthritis. Some of its ethnomedicinal uses have been justified via scientific studies, include antidiabetic, antioxidant, anti-inflammatory and antimicrobial effects. Recently, several studies have been initiated to investigate the role of Tinospora species in wound healing. This comprehensive review used updated information obtained from systematic literature search using PubMed, Scopus, Science Direct and Google Scholar, to assess the wound healing properties of eleven major Tinospora species namely, T. cordifolia, T. crispa, T. sagittata, T. sinensis, T. bakis, T. craveniana, T. tuberculata, T. capillipes, T. rumphii, T. smilacina, and T. baenzigeri. The information obtained revealed that only T. cordifolia and T. crispa have been reported on its wound-healing abilities. Studies demonstrated that T. cordifolia is associated with early re-epithelisation, enhanced tensile strength, increased granulation tissues and increased collagen contents. Whereas T. crispa is reported with wound healing activity through the elevated antioxidant enzymes and inflammation phase. Nevertheless, there is limited evidence on phytochemical constituents from plant extracts that contribute to the wound healing process and their underlying mechanisms. This review deduced the potential gaps for future research aiming to study the genus Tinospora as a potential wound healing agent.

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Section: Tinospora Cordifoliamentioning

confidence: 99%

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

Section: Fig 1: Flow Chart Of the Article Screening Phase Based On The Inclusion And Exclusion Criteriamentioning

confidence: 99%

See 2 more Smart Citations

The Potential Role of Genus Tinospora in Wound Healing: A Review

Fernandez¹,

Shivashekaregowda²,

Yow³

2021

Int J Pharm Pharm Sci

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“…Leaf extracts of this plant protected finfish from experimental infection with Aeromonas hydrophila, which indicated its value as an immunoprophylactic agent [167]. A clinical study also linked the immunomodulatory role of the TC plant in the improved healing of diabetic foot ulcers and wounds in Wistar rats, by increasing the rate of epithelialization, and enhanced the scavenging of free radicals [168,169]. Mukherjee et al [170] studied Tinospora root extracts in the treatment of bovine clinical mastitis and observed the antibacterial and immunomodulatory effects.…”

Section: Tinospora Cordifolia (Giloy-menispermaceae)mentioning

confidence: 99%

Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Tiwari

Latheef

Ahmed

et al. 2018

CDM

121

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Natural 3D Extra Cellular Matrix mimicking stem cells seeded decellularized scaffolds as a platform for tendon regeneration

John

Joseph

et al. 2023

J Biomed Mater Res

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Achilles tendon, which connects the calf muscles to heel, is the strongest tendon in the body. Despite its strength, it is more prone to injury due to its limited blood supply. Tendon-related injuries are more common in sportspersons, people with laborintensive work and the aged community. The currently available treatment mode is surgery which is expensive with chances of re-injury. Present study made an attempt to fabricate a tissue-engineered tendon product using decellularized tendon (DT) seeded with stem cells and bioactive components of Tinospora cordifolia extract (TCE). The bare DT tissue scaffold/substitute may also serve as a drug delivery platform for growth factors and cells with a new approach to promote tissue regeneration in clinical applications. DT construct showed good regenerative potential and easily promoted new tissue formation. Decellularization of the tendon was carried out by chemical method using tri (n-butyl) phosphate (TnBP). DT was physicochemically characterized by contact angle measurement, thermal gravimetric analysis (TGA), and mechanical testing. Rabbit adipose derived mesenchymal stem cells (RADMSCs) were isolated and phenotypically characterized by flow cytometry analysis, tri lineage differentiation, and so forth. Further, stem cell seeded DT scaffolds were prepared and found to be non-toxic by cytotoxicity, cell adhesion by scanning electron microscope (SEM) analysis, cell viability by live dead assays, and so forth.The findings of this study yield valid proof for the employability of cell-seeded DT construct as a natural scaffold in repairing injured tendons-the toughest chords of the skeleton. This is a cost effective method for the replacement of injured/damaged tendons for athletes, people in labor-intensive occupations, the elderly population, and so forth-a boon towards the repair of the tendon in damage/injury.

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Influence of Tinospora cordifolia on wound healing in wistar rats

Cited by 12 publications

References 17 publications

The Potential Role of Genus Tinospora in Wound Healing: A Review

The Potential Role of Genus Tinospora in Wound Healing: A Review

Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Natural 3D Extra Cellular Matrix mimicking stem cells seeded decellularized scaffolds as a platform for tendon regeneration

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