Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis

Abstract

FH patients with a poor prognosis had higher frequencies of positions -1031C and -863A in the TNF-alpha promoter region, and higher frequencies of the B2 allele of the TNF-beta gene. These data suggest that the genomic background may be associated with the prognosis of acute liver failure.

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

“…37 The other TNF promoter polymorphisms (rs361525, rs1800629 and rs1799724) that are known to influence TNF-a level were not associated with HBV outcome in this study. However, many studies have shown the association of these polymorphisms with diverse HBV outcomes.…”

“…However, many studies have shown the association of these polymorphisms with diverse HBV outcomes. [37][38][39][40][41] The reason for this nonassociation in the South Indian population is presently not known.…”

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

“…We followed the methods described previously (Tsuchiya et al, 2004). A 782-bp fragment of genomic DNA containing the polymorphic Nco I restriction site was amplified.…”

“…TNFβ has been implicated in the pathogenesis of acute and chronic HBV/HCV infection (Goyal et al, 2004;Tsuchiya et al, 2004;Suneetha et al, 2006). Recently, TNFβ, LTβ and LTβ receptor are shown to be upregulated in HBV-or HCV-induced hepatitis and HCC (Haybaeck et al, 2009).…”

“…The latter has been linked to increased production of both TNFβ (Messer et al, 1991;Menges et al, 2008) and TNFα (Menges et al, 2008), respectively. The TNFβ allele has been linked with several inflammatory, autoimmune, infectious, and malignant diseases (Messer et al, 1991;Goyal et al, 2004;Tsuchiya et al, 2004;Suneetha et al, 2006;Menges et al, 2008;Haybaeck et al, 2009).…”