Influence of tooth surface conditions on enamel fluoride uptake after topical application of TiF<sub>4</sub>in vitro

Gu, Zhiling; Li, Jianguo; Söremark, Rune

doi:10.3109/00016359609003538

Cited by 31 publications

(32 citation statements)

References 8 publications

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“…22 In addition, TiF 4 has the ability to form an acid-resistant titanium dioxide surface film when in contact with the dental enamel surface. 4,9,10,11 The protective effect of the amorphous acid-resistant film might be mainly related to its ability to act as Table 2. EDS analysis of the surface of enamel blocks; chemical elements are shown according to the treatments (means ± standard deviation).…”

Section: Discussionmentioning

confidence: 99%

“…It has a profound ability to protect against demineralization due to the deposition of CaF 2 and formation of an acidresistant titanium dioxide (TiO 2 ) layer on the enamel. 4,9,10,11 TiF 4 solution is a promising anticaries compound, but it is unstable and presents a low pH value and, because of that, it is not well accepted for clinical use. 9 To overcome this problem, some authors tested the anticaries 6 and antierosive 12 potential of a TiF 4 varnish.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…4,9,10,11 TiF 4 solution is a promising anticaries compound, but it is unstable and presents a low pH value and, because of that, it is not well accepted for clinical use. 9 To overcome this problem, some authors tested the anticaries 6 and antierosive 12 potential of a TiF 4 varnish. However, other studies are needed to elucidate the effect of TiF 4 varnish in a situation that mimics the oral environment as in an in situ model.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

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In situ effect of titanium tetrafluoride varnish on enamel demineralization

et al. 2017

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The effect of a 4% titanium tetrafluoride (TiF 4 ) varnish on enamel demineralization was evaluated. Twelve volunteers participated in this double-blind, randomized crossover study. Six enamel specimens were positioned in intraoral appliances throughout four treatment stages: 4% TiF 4 varnish (experimental varnish), 5% sodium fluoride (NaF) varnish (Duraphat ® ), placebo varnish, and negative control (deionized water). After 24 h, the varnishes were removed and plaques were allowed to accumulate. A 20% sucrose solution was dripped onto enamel blocks (10x/day). Enamel alterations were analyzed by surface microhardness (SMH), percentage of surface loss (%SML), cross-sectional microhardness (CSMH), scanning electron microscopy (SEM), and energy dispersive X-ray spectrometry (EDS). Student's paired t-test was used for SMH analysis and repeated-measures analysis of variance (ANOVA) for %SML and CSMH (∆Z) analyses (p-value=0.05). The TiF 4 varnish group had lower %SML than the placebo and control groups (p=0.044 and p=0.003, respectively), thus showing its capacity to inhibit surface demineralization. TiF 4 and NaF varnishes demonstrated a protective effect against mineral loss on the enamel subsurface. Both were statistically different from the control group when CSMH was analyzed (p=0.000). A titanium dioxide film was observed on enamel surfaces of the TiF 4 group SEM images. EDS confirmed the presence of titanium in all TiF 4 samples. The 4% TiF 4 varnish is a promising compound capable of reacting with enamel to protect it against surface and subsurface demineralization.

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Section: Discussionmentioning

confidence: 99%

Section: Declaration Of Interestsmentioning

confidence: 99%

Section: Declaration Of Interestsmentioning

confidence: 99%

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In situ effect of titanium tetrafluoride varnish on enamel demineralization

et al. 2017

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“…Moreover, it is suggested that titanium interacts with organic components of the enamel surface, leading to an increased fluoride uptake by enamel. 14,17 However, Mundorff et al 14 suggested that hafnium and zirconium might be unable to form an acid-stable surface glaze. In contrast, by SEM analysis it could be shown that pretreatment of enamel surface with different polyvalent ions followed by application of acidulated phosphate fluoride lead to the formation of an amorphous coating on the enamel surface.…”

Section: Discussionmentioning

confidence: 99%

Protection of short-time enamel erosion by different tetrafluoride compounds

Wiegand

Laabs

Gressmann

et al. 2008

Archives of Oral Biology

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OBJECTIVE: This in vitro study aimed to analyse the protective effect of differently concentrated titanium (TiF(4)), zirconium (ZrF(4)) and hafnium (HfF(4)) tetrafluoride on enamel erosion. METHODS: Polished enamel surfaces of 36 bovine crowns were covered with tape leaving 4 enamel windows each 3mm in diameter exposed. The crowns were randomly assigned to six groups (each n=6) and pretreated with 4% TiF(4), 10% TiF(4), 4% ZrF(4), 10% ZrF(4), 4% HfF(4) or 10% HfF(4) for 4 min (first window), 10 min (second window) or 15 min (third window). The fourth window of each crown was not pretreated and served as control. Erosion was performed stepwise with 1% HCl (pH 2) in five consecutive intervals of each 15 s (total 75 s). Enamel dissolution was quantified by colorimetric determination of phosphate release into the acid. For each tooth, cumulative phosphate loss of enamel pretreated with one of the tetrafluoride compounds was calculated as percentage of the respective control and statistically analysed using two-way ANOVA. RESULTS: Enamel erosion was significantly reduced by TiF(4), ZrF(4) and HfF(4) application. Cumulative phosphate loss (mean % of control, 75s erosion) after 4-15 min application was significantly lower for 4% ZrF(4) (7-11%), 10% ZrF(4) (2-6%), 4% HfF(4) (11-9%) and 10% HfF(4) (12-16%) compared to 4% TiF(4) (42-27%) and 10% TiF(4) (54-33%). Only for 4% and 10% TiF(4), phosphate loss decreased with increasing duration of application, but also increased with increasing acid intervals. CONCLUSION: TiF(4), ZrF(4) and HfF(4) might protect enamel against short-time erosion, but protection was more enhanced by ZrF(4) and HfF(4) compared to TiF(4) application overtime. 1 Protection of short-time enamel erosion by different tetrafluoride compounds AbstractObjective: This in-vitro-study aimed to analyse the protective effect of differently concentrated titanium (TiF 4 ), zirconium (ZrF 4 ) and hafnium (HfF 4 ) tetrafluoride on enamel erosion.Methods: Polished enamel surfaces of 36 bovine crowns were covered with tape leaving 4 enamel windows each 3 mm in diameter exposed. The crowns were randomly assigned to 6 groups (each n = 6) and pretreated with 4% TiF 4 , 10% TiF 4 , 4% ZrF 4 , 10% ZrF 4 , 4% HfF 4 or 10% HfF 4 for 4 min (1 st window), 10 min (2 nd window) or 15 min (3 rd window). The 4 th window of each crown was not pretreated and served as control. Erosion was performed stepwise with 1% HCl (pH 2) in five consecutive intervals of each 15 s (total 75 s). Enamel dissolution was quantified by colorimetric determination of phosphate release into the acid.For each tooth, cumulative phosphate loss of enamel pretreated with one of the tetrafluoride compounds was calculated as percentage of the respective control and statistically analysed using two-way ANOVA.Results: Enamel erosion was significantly reduced by TiF 4 , ZrF 4 and HfF 4 application.Cumulative phosphate loss (mean % of control, 75 s erosion) after 4-15 min application was significantly lower for 4% ZrF 4 (7-11%), 10% ZrF 4 (2-6%), 4% HfF ...

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“…The electrostatic interaction between TiF 4 and acquired film proteins 36 and the presence of organic matrix on the dental surface 37 are capable of positively influencing the incorporation of fluoride by dental tissue 34 . Besides, the formation of an acid-resistant layer occurs on the dental surface 28,29,31,38 , which resembles to a glaze, and is ultrastructurally composed of numerous spherical particles 31,39 .…”

Section: Titanium Tetrafluoridementioning

confidence: 99%

Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion

Mantilla

Freitas

2018

J. Health Scie.

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Dental erosion is a multifactorial pathology that leads to dental substrate loss caused by its exposure to acids of non-bacterial origin. The process begins with a superficial demineralization of enamel, which, when continuously exposed to erosive solutions, can even lead to dentin exposure, causing aesthetic/functional problems to patients, besides increasing the chances of dentin hypersensitivity. Fluoride ResumoA erosão dental é uma patologia multifatorial que leva a uma perda de substrato dental causada pela sua exposição a ácidos de origem não-bacteriana. O processo se inicia com uma desmineralização superficial do esmalte, que, quando da continua exposição a soluções erosivas, pode levar a exposição do esmalte, causando problemas estéticos/funcionais aos pacientes, além de aumentar a chance de hipersensibilidade dentinária. Os produtos fluoretados, quando aplicados sobre a superfície dental, formam uma barreira física de proteção, que também pode agir como reservatório de íons F. Entretanto, frente a recorrentes desafios erosivos, esta proteção tem efetividade limitada. A literatura recente já demonstrou a capacidade de compostos contendo cátions metálicos polivalentes associados a fluoretos, incluindo o tetrafluoreto de titânio (TiF 4 ), para formar camadas mais ácido-resistentes. A capacidade do íon titânio de se ligar simultaneamente aos íons F e ao tecido dental permite a formação de uma barreira de difusão na superfície dental, conhecida como glaze, que a protege contra desmineralização ácida. Entretanto, ainda é necessário estabelecer um protocolo clínico ideal envolvendo a definição de fatores capazes de determinar o sucesso do tratamento, como concentração, pH, veículo e forma/tempo de aplicação, além da frequência para reaplicação. A presente revisão crítica tem como objetivo proporcionar uma breve visão geral dos mecanismos de ação do TiF 4 e discutir os fatores que podem melhorar sua capacidade protetora contra a erosão dental.Palavras-chave: Erosão Dentária. Flúor. Titânio.

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Influence of tooth surface conditions on enamel fluoride uptake after topical application of TiF₄in vitro

Cited by 31 publications

References 8 publications

In situ effect of titanium tetrafluoride varnish on enamel demineralization

In situ effect of titanium tetrafluoride varnish on enamel demineralization

Protection of short-time enamel erosion by different tetrafluoride compounds

Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion

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Influence of tooth surface conditions on enamel fluoride uptake after topical application of TiF4in vitro

Cited by 31 publications

References 8 publications

In situ effect of titanium tetrafluoride varnish on enamel demineralization

In situ effect of titanium tetrafluoride varnish on enamel demineralization

Protection of short-time enamel erosion by different tetrafluoride compounds

Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion

Contact Info

Product

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Influence of tooth surface conditions on enamel fluoride uptake after topical application of TiF₄in vitro