Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin

Lademann, Juergen; Vergou, Theognosia; Darvin, Maxim E.; Patzelt, Alexa; Meinke, Martina C.; Voit, Christiane; Papakostas, Dimitrios; Zastrow, L.; Sterry, Wolfram; Doucet, Olivier

doi:10.1159/000441953

Cited by 30 publications

(22 citation statements)

References 36 publications

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“…The modulation of serum lipid profiles by almond supplementation has been studied in detail. Conversely, their effects on the skin's lipid barrier function are under studied, although alteration of the skin barrier can improve several skin features including wrinkles (Lademann et al, 2016;Yoon et al, 2016). The sebaceous glands, housed within the dermis, are in close contact to systemic blood circulation.…”

Section: Introductionmentioning

confidence: 99%

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles

Foolad

Vaughn

Rybak

et al. 2019

Phytotherapy Research

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ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated. The aim of this study was to investigate the effects of almond consumption on facial sebum production and wrinkles.MethodsThis was a prospective, investigator‐blinded, randomized controlled trial in which subjects consumed 20% of their daily energy consumption in either almonds or a calorie‐matched snack for 16 weeks. This study was completed at the UC Davis Dermatology clinic. Participants were a volunteer sample of generally healthy postmenopausal females with Fitzpatrick skin types 1 and 2. A facial photograph and image analysis system was used to obtain standardized photographs and information on wrinkle width and severity at 0, 8, and 16 weeks. Measurements of transepidermal water loss and sebum production were also completed at 0, 8, and 16 weeks.ResultsFifty healthy postmenopausal females were recruited, 31 participants were enrolled, and 28 completed the study. Under photographic analysis, the almond group had significantly decreased wrinkle severity and width compared with the control group at 16 weeks (p < .02). Changes in skin barrier function were nonsignificant, measured by the transepidermal water loss (p = .65) between the almond and control groups relative to baseline after 16 weeks. No adverse effects were reported.ConclusionOur study demonstrates that daily almond consumption may reduce wrinkle severity in postmenopausal females to potentially have natural antiaging benefits.

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Section: Introductionmentioning

confidence: 99%

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles

Foolad

Vaughn

Rybak

et al. 2019

Phytotherapy Research

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“…In support of this notion, the recent report by Lademann et al, in 2016, showed that antioxidants positively influenced the barrier function of human skin [87]. For example, antioxidants significantly increased epidermal thickness, elasticity, and stratum corneum moisture content [87].…”

Section: Equol Is Delivered Into Human Skin Via a Unique "Reservoir" mentioning

confidence: 92%

“…Undoubtedly, equol may enhance the skin's barrier function and cellular integrity via its topical application and sustained delivery mechanism [12,82]. In support of this notion, the recent report by Lademann et al, in 2016, showed that antioxidants positively influenced the barrier function of human skin [87]. For example, antioxidants significantly increased epidermal thickness, elasticity, and stratum corneum moisture content [87].…”

Section: Equol Is Delivered Into Human Skin Via a Unique "Reservoir" mentioning

confidence: 98%

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart

2018

Cosmetics

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Environmental pollutants represent a major problem worldwide that cannot be passively avoided. It is known that skin sensitivities can result from environmental assaults, such as toxins and pollutants in air and water. Additionally, dermal assaults from wind and exposure to seasonal cold temperatures are known. All of these environmental assaults are associated with oxidative stress and the intracellular generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins and mitochondrial function. Additionally, the influence of diet on dermal health and, especially, antioxidant defense in skin function are well established. In this regard, environmental pollution worldwide has generated a high demand for anti-pollution personal care products to protect the skin against the daily exposure of airborne toxins and various other assaults. Major cosmetic companies have anti-pollution personal care products but, in general, the products are formulated with commonly used active ingredients that have been retooled with market strategies to address current environmental pollution treatments. Equol is a new botanical active ingredient compound for skin applications. It has a polyphenolic chemical structure found in plant and food products, and is also classified as an isoflavonoid. Moreover, equol appears to address the need for an active ingredient in personal care products to protect against pollution assaults by increasing antioxidant defense, while inhibiting oxidative stress and inflammation. Separate sections covering equol's enhanced (a) delivery mechanism into human skin; (b) antioxidant effects via Nrf2 activation; (c) effects on extracellular matrix proteins like collagen and elastin and; (d) protection against oxidative stress and inflammation are presented.

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“…Measurements by this device were conducted on an area with a diameter of 50 mm by the miniaturized sensor that was placed in between the textile and the skin upon occlusion measuring the temperature and relative humidity at intervals of 20 seconds in 20 subjects. For comparison, the temperature and hydration were also measured before and after the 60 minute textile application using established measurement devices, such as an infrared thermometer (Raytek ® , Fluke Process Instruments GmbH, Berlin, Germany), for the assessment of the temperature and a Corneometer CM 825 (Courage ‐ Khazaka Electronic, Cologne, Germany), for the assessment of the skin hydration . These measurements were performed on the palm, which is characterized by a high sweat gland density.…”

Section: Methodsmentioning

confidence: 99%

“…For comparison, the temperature and hydration were also measured before and after the 60 minute textile application using established measurement devices, such as an infrared thermometer (Raytek ® , Fluke Process Instruments GmbH, Berlin, Germany), for the assessment of the temperature and a Corneometer CM 825 (Courage -Khazaka Electronic, Cologne, Germany), for the assessment of the skin hydration. 34 These measurements were performed on the palm, which is characterized by a high sweat gland density.…”

Section: Transepidermal Water Loss (Tewl)mentioning

confidence: 99%

Influence of polyester spacer fabric, cotton, chloroprene rubber, and silicone on microclimatic and morphologic physiologic skin parameters in vivo

Jung

Schleusener

Knorr

et al. 2019

Skin Research and Technology

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Background Skin diseases can develop upon disadvantageous microclimate in relation to skin contact with textiles of supporting devices. Increased temperature, moisture, mechanical fracture, pressure, and inflammatory processes often occur mutually and enhance each other in their adverse effects. Therefore, the early prevention of skin irritations by improvement of microclimatic properties of skin in contact with supporting devices is important. Materials and Methods In this study, the microclimate under occlusion with polyester, cotton, chloroprene rubber, and silicone textiles, used for supporting devices, was analyzed by determining several characteristic physiologic skin parameters in vivo, including temperature, moisture, and transepidermal water loss (TEWL). This is achieved by comparing a miniaturized in vivo detection device with several established optical and sensory methods in vivo. Results A highly significant TEWL decrease was found after polyester, chloroprene rubber, and silicone application. The application of all materials showed highly significant decrease in skin surface temperature, with chloroprene rubber showing the lowest. Similarly, all materials showed highly significant increase in relative moisture, where the highest increase was found for chloroprene rubber and silicone and the lowest increase for cotton. The cutaneous carotenoid concentration of chloroprene rubber, silicone, and polyester decreased. A manipulation of the surface structure of the stratum corneum was recognized for all materials except for cotton by laser scanning microscopy. Conclusion The skin parameters temperature, relative moisture, antioxidant status, and TEWL can effectively characterize the microclimatic environment during occlusion with medical supporting materials. These parameters could potentially be used to develop standardized testing procedures for material evaluation.

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Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin

Cited by 30 publications

References 36 publications

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Influence of polyester spacer fabric, cotton, chloroprene rubber, and silicone on microclimatic and morphologic physiologic skin parameters in vivo

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