Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation

Ryu, Hyun Wook; Lee, Dong Hoon; Won, Hye Rim; Kim, Kyeong Hwan; Seong, Yun Jeong; Kwon, So Hee

doi:10.5487/tr.2015.31.1.001

Cited by 70 publications

(43 citation statements)

References 87 publications

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“…Women living near industries that emit heavy metals are at increased risk of having children that have chromosomal anomalies [48]. Exposure to toxic metals can also cause epigenetic changes that result in persistent negative changes [47,49]. Knowledge about genetic and epigenetic effects of environmental exposures may enable MCA Latinos to work with each other and their advocates more effectively to reduce toxic exposures within their communities.…”

Section: Discussionmentioning

confidence: 99%

“He Beat You in the Blood”: Knowledge and Beliefs About the Transmission of Traits Among Latinos from Mexico and Central America

Sandberg

López-Rodríguez

Howard

et al. 2015

J Immigrant Minority Health

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Purpose Genomic literacy is becoming increasingly important. Knowledge about how Latinos from Mexico and Central America (MCA) think and speak about how traits are shared by family members is needed. Methods Semi-structured in-depth interviews were conducted with 16 MCA Latino men and women. Interviews elicited detailed information about participant beliefs and knowledge about intergenerational trait transmission, genes and genetics. Transcripts were systematically analyzed. Results Most participants had familiarity with the role of genes. Knowledge about gene function was limited. Participants used “blood talk” to discuss awareness that traits are transmitted between generations and to express that blood itself plays a crucial role often, but not necessarily, in conjunction with genes or DNA to transmit traits. Conclusion Health educators need to directly address potential confusion about blood’s role in the transmission of traits. Culturally and linguistically appropriate materials are needed to present genetic and genomic information to MCA Latinos.

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Section: Discussionmentioning

confidence: 99%

“He Beat You in the Blood”: Knowledge and Beliefs About the Transmission of Traits Among Latinos from Mexico and Central America

Sandberg

López-Rodríguez

Howard

et al. 2015

J Immigrant Minority Health

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“…Long-term Cd treatment resulted in increased DNMT3b transcript levels leading to increased DNMT activity, promoter hypermethylation and loss of expression of tumor suppressor genes RASSF1A and p16. Cd has been shown to alter histone modification and microRNA levels in vitro ( 20 ).…”

Section: Cadmium Exposure and Health Effectsmentioning

confidence: 99%

Cadmium Exposure and Potential Health Risk from Foods in Contaminated Area, Thailand

Chunhabundit

2016

ToxicolRes

196

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Man-made cadmium (Cd) emissions can be transported between environmental matrices and the food chain. Food is the primary source of Cd exposure among general population as a consequence of the bio-concentration of Cd from soil. Chronic Cd exposure has been reported to be associated with chronic kidney disease, osteoporosis, diabetes, cardiovascular disease and cancer. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) established the safe level of Cd intake as provisional tolerable monthly intake (PTMI) of 25 μg/kg bw in 2010. The major food groups that contribute to the most Cd exposure are rice and grains, shellfish and sea food, meat including edible offal, and vegetables. A number of studies reported the high Cd contaminated levels in foods from polluted areas in Thailand. The results are of high concern since the contaminations occur in foods that are major Cd contributors. Thus, in this review, the current situations of Cd contaminated foods in polluted areas of Thailand are summarized. In addition, the Cd intakes from selected scenarios are estimated to assess the potential health risk to consumers and the suggestions are also included.

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“…DNA methylation has been suggested to involve in regulation of gene expression and associate with a series of copper induced demyelinating diseases such as WD and AD (16, 17). In this study, it was unveiled that pou3f1 , pou3f2 and fam168b exhibited down-regulated expression but hypermethylation separately in their promoter in Cu 2+ stressed embryos.…”

Section: Discussionmentioning

confidence: 99%

Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5bSignaling and Underlying DNA Methylation

Guan

Zhao

et al. 2019

Preprint

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29 Unbalanced copper (Cu 2+ ) homeostasis is associated with neurological development defects and 30 diseases. However, the molecular mechanisms remain elusive. Here, central neural system (CNS) myelin 31 defects and down-regulated expression of Wnt/Notch signaling and their down-stream mediator hoxb5b 32 were observed in Cu 2+ stressed zebrafish larvae. Loss/knockdown-of-function of hoxb5b phenocopied 33 the myelin and axon defects observed in Cu 2+ stressed embryos. Meanwhile, activation of Wnt/Notch 34 signaling and ectopic expression of hoxb5b could rescue copper-induced myelin defects, suggesting 35 Wnt&Notch-hoxb5b axis mediated Cu 2+ induced myelin and axon defects. Additionally, whole genome 36 DNA methylation sequencing unveiled that a novel gene fam168b, similar to pou3f1/2, exhibited 37 significant promoter hypermethylation and reduced expression in Cu 2+ stressed embryos. The 38 hypermethylated locus in fam168b promoter acted pivotally in its transcription, and loss/knockdown of 39 fam168b/pou3f1 also induced myelin defects. Moreover, this study unveiled that fam168b/pou3f1 and 40 hoxb5b axis acted in a seesaw manner during fish embryogenesis, and demonstrated that copper induced 41 the down-regulated expression of the Wnt&Notch-hoxb5b axis dependent of the function of copper 42 transporter cox17, coupled with the promoter methylation of genes fam168b/pou3f1 and their subsequent 43 down-regulated expression dependent of the function of another transporter atp7b, making joint 44 contributions to myelin defects in embryos. Those data will shed some light on the linkage of unbalanced 45 copper homeostasis with specific gene promoter methylation and signaling transduction as well as the 46 resultant neurological development defects and diseases.47 48 Author summary 49In this study, we first unveiled that copper induced central neural system (CNS) myelin defects via 50 3 down-regulating Wnt/Notch-hoxb5b signaling, and parallel with hypermethylating promoters of genes 51 fam168b/pou3f2 and their subsequent down-regulated expression. Additionally, we unveiled that 52 fam168b/pou3f1 and hoxb5b axis acted in a seesaw manner during fish embryogenesis. Genetically, we 53 unveiled that copper was trafficked to mitochondrion via cox17 then led to the down-regulation of 54 Wnt&Notch-hoxb5b axis, and was trafficked to trans-Golgi network via atp7b to induce the 55 hypermethylation and the down-regulated expression of pou3f1/fam168b genes, making joint 56 contributions to myelin defects in embryos.

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Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation

Cited by 70 publications

References 87 publications

“He Beat You in the Blood”: Knowledge and Beliefs About the Transmission of Traits Among Latinos from Mexico and Central America

“He Beat You in the Blood”: Knowledge and Beliefs About the Transmission of Traits Among Latinos from Mexico and Central America

Cadmium Exposure and Potential Health Risk from Foods in Contaminated Area, Thailand

Copper Induces Zebrafish Central Neural System Myelin Defects: the Regulatory Mechanisms in Wnt/Notch-hoxb5bSignaling and Underlying DNA Methylation

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